Danielle Hamstra studied at Leiden University, where she graduated in 2013 in Clinical and Health Psychology (Research). In her PhD research she aims to contribute to the personalized treatment of depression in women. She is also a teacher at the department of Clinical Psychology.
The mineralocorticoid receptor haplotype, female hormones and cognitive-affective processes associated with depression.
Why are women more vulnerable to mood disorders than men? Depression is the result of an inability to cope with stressors. The genetically determined sensitivity of the mineralocorticoid receptor (MR haplotype) plays an important role in this process. Currently we are investigating the relation between the MR haplotype, depression and female hormones in both healthy volunteers and clinical samples.
In our previous research we found coincidentally that oral contraceptives alter the detection of emotions in facial expressions. A follow-up study revealed that the impact of OCs on emotional information processing is moderated by MR-haplotype. Our latest study showed that these genes also influence the impact of the menstrual cycle on emotional cognition.
Thesis supervision (bachelor and master); Advanced Underpinnings of Biological Psychiatry, Experimental Clinical Psychology; Psychopathologie, Diagnostiek en Behandeling.
- Hamstra DA, De Rover M, De Rijk RH, Van der Does AJW (2014). Oral contraceptives may alter the detection of emotions in facial expressions. Eur Neuropsychopharmacol 11:1855–1859
- Hamstra DA, de Kloet ER, van Hemert AM, de Rijk RH, Van der Does W (2015a). Mineralocorticoid receptor haplotype, oral contraceptives and emotional information processing. Neuroscience 286: 412–422.
- Hamstra DA, de Kloet ER, Tollenaar, M, Verkuil, B, Manai, M, Putman, P, Van der Does W (2015b). Mineralocorticoid receptor haplotype moderates the influence of Female hormones and oral contraceptives on emotional cognition. Submitted.