Universiteit Leiden

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Daniëlle Hamstra

Drs. D.A. Hamstra
+31 71 527 2727

Danielle Hamstra studied at Leiden University, where she graduated in 2013 in Clinical and Health Psychology (Research). In her PhD research she aims to contribute to the personalized treatment of depression in women. She is also a teacher at the department of Clinical Psychology.

More information about Daniëlle Hamstra

Research topic

The mineralocorticoid receptor haplotype, female hormones and cognitive-affective processes associated with depression.


Current research

Why are women more vulnerable to mood disorders than men? Depression is the result of an inability to cope with stressors. The genetically determined sensitivity of the mineralocorticoid  receptor (MR haplotype) plays an important role in this process. Currently we are investigating the relation between the MR haplotype, depression and female hormones in both healthy volunteers and clinical samples.

In our previous research we found coincidentally that oral contraceptives alter the detection of emotions in facial expressions. A follow-up study revealed that the impact of OCs on emotional information processing is moderated by MR-haplotype. Our latest study showed that these genes also influence the impact of the menstrual cycle on emotional cognition.



Thesis supervision (bachelor and master); Advanced Underpinnings of Biological Psychiatry, Experimental Clinical Psychology; Psychopathologie, Diagnostiek en Behandeling.


Relevant links



  • Hamstra DA, De Rover M, De Rijk RH, Van der Does AJW (2014). Oral contraceptives may alter the detection of emotions in facial expressions.  Eur Neuropsychopharmacol 11:1855–1859
  • Hamstra DA, de Kloet ER, van Hemert AM, de Rijk RH, Van der Does W (2015a). Mineralocorticoid receptor haplotype, oral contraceptives and emotional information processing.  Neuroscience 286: 412–422.
  • Hamstra DA, de Kloet ER, Tollenaar, M, Verkuil, B, Manai, M, Putman, P, Van der Does W (2015b). Mineralocorticoid receptor haplotype moderates the influence of Female hormones and oral contraceptives on emotional cognition.  Submitted.

  • Faculteit der Sociale Wetenschappen
  • Instituut Psychologie
  • Klinische Psychologie

Work address

Pieter de la Court
Wassenaarseweg 52
2333 AK Leiden



  • Sensoor Vrijwilliger
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