Clemens Löwik
- Name
- Prof.dr. C.W.G.M. Löwik
- Telephone
- +31 71 526 3075
- c.w.g.m.lowik@lumc.nl
- Faculteit Geneeskunde
- Divisie 2
- Interne Geneeskunde
- Endocrinologie
- Bruijn, H.S. de; Mashayekhi, V.; Schreurs, T.J.L.; Driel, P.B.A.A. van; Strijkers, G.J.; Diest, P.J. van; Lowik, C.W.G.M.; Seynhaeve, A.L.B.; Hagen, T.L.M. ten; Prompers, J.J.; Henegouwen, P.M.P.V.E.; Robinso, D.J. & Oliveira, S. (2020), Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging, Theranostics 10(5): 2436-2452.
- Schomann, T.; Mezzanotte, L.; Groot, J.C.M.J. de; L?wik, C.W.G.M.; Frijns, J.H.M. & Huisman, M.A. (2019), Imaging bioluminescent exogenous stem cells in the intact guinea pig cochlea, Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology.
- Liu, X.M.; Que, I.; Kong, X.G.; Zhang, Y.L.; Tu, L.P.; Chang, Y.L.; Wang, T.T.; Chan, A.; Lowik, C.W.G.M. & Zhang, H. (2016), In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform (vol 7, pg 14914, 2015), Nanoscale 8(33): 15358-15358.
- Stammes, M.A.; Knol-Blankevoort, V.T.; Cruz, L.J.; Feitsma, H.R.I.J.; Mezzanotte, L.; Cordfunke, R.A.; Sinisi, R.; Dubikovskaya, E.A.; Maeda, A.; DaCosta, R.S.; Bierau, K.; Chan, A.; Kaijzel, E.L.; Snoeks, T.J.A.; Beek, E.R. van & Lowik, C.W.G.M. (2016), Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging, Molecular Imaging and Biology 18(6): 905-915.
- Driel, P.B.A.A. van; Boonstra, M.C.; Prevoo, H.A.J.M.; Giessen, M.V. van de; Snoeks, T.J.A.; Tummers, Q.R.J.G.; Keereweer, S.; Cordfunke, R.A.; Fish, A.; Eendenburg, J.D.H. van; Lelieveldt, B.P.F.; Dijkstra, J.; Velde, C.J.H. van de; Kuppen, P.J.K.; Vahrmeijer, A.L.; Lowik, C.W.G.M. & Sier, C.F.M. (2016), EpCAM as multi-tumour target for near-infrared fluorescence guided surgery, BMC Cancer 16.
- Malysheva, K.; Rooij, K. de; Lowik, C.W.G.M.; Baeten, D.L.; Rose-John, S.; Stoika, R. & Korchynskyi, O. (2016), Dickkopf-1 and interleukin 6 interaction as a potential mechanism of Wnt pathway inhibition in rheumatoid arthritis, FEBS Journal 283: 25-26.
- Lucassen E.A., Coomans C.P., Putten M. van, Kreij S.R. de, Genugten J.H.L.T. van, Sutorius R.P.M., Rooij K.E. de, Velde M. van der, Verhoeve S.L., Smit J.W.A., Lowik C.W.G.M., Smits H.H., Guigas B., Aartsma-Rus A.M. & Meijer J.H. (2016), Environmental 24-hr Cycles Are Essential for Health, Current Biology 26(14): 1843-1853.
- Lucassen, E.A.; Coomans, C.P.; Putten, M. van; Kreij, S.R. de; Genugten, J.H.L.T. van; Sutorius, R.P.M.; Rooij, K.E. de; Velde, M. van der; Verhoeve, S.L.; Smit, J.W.A.; Lowik, C.W.G.M.; Smits, H.H.; Guigas, B.; Aartsma-Rus, A.M. & Meijer, J.H. (2016), Environmental 24-hr Cycles Are Essential for Health, Current Biology 26(14): 1843-1853.
- Selt, M.; Tennstaedt, A.; Beyrau, A.; Nelles, M.; Schneider, G.; Lowik, C. & Hoehn, M. (2016), In Vivo Non-Invasive Tracking of Macrophage Recruitment to Experimental Stroke, PLoS ONE 11(6).
- Kijanka, G.; Bee, J.S.; Bishop, S.M.; Que, I.; Lowik, C. & Jiskoot, W. (2016), Fate of Multimeric Oligomers, Submicron, and Micron Size Aggregates of Monoclonal Antibodies Upon Subcutaneous Injection in Mice, Journal of Pharmaceutical Sciences 105(5): 1693-1704.
- Cruz, L.J.; Que, I.; Aswendt, M.; Chan, A.; Hoehn, M. & Lowik, C. (2016), Targeted nanoparticles for the non-invasive detection of traumatic brain injury by optical imaging and fluorine magnetic resonance imaging, Nano Research 9(5): 1276-1289.
- Kijanka G.M., Bee J.S., Bishop S.M., Que I., Löwik C.W.G.M. & Jiskoot W. (2016), Fate of multimeric oligomers, submicron, and micron size aggregates of monoclonal antibodies upon subcutaneous injection in mice, Journal of Pharmaceutical Sciences 105(5): 1693-1704.
- Driel, P.B.A.A. van; Boonstra, M.C.; Slooter, M.D.; Heukers, R.; Stammes, M.A.; Snoeks, T.J.A.; Bruijn, H.S. de; Diest, P.J. van; Vahrmeijer, A.L.; Henegouwen, P.M.P.V.E.; Velde, C.J.H. van de; Lowik, C.G.M.; Robinson, D.J. & Oliveira, S. (2016), EGFR targeted nanobody-photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer, Journal of Controlled Release 229: 93-105.
- Malysheva, K.; Rooij, K. de; Lowik, C.W.G.M.; Baeten, D.L.; Rose-Johns, S.; Stoika, R. & Korchynskyi, O. (2016), Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts, Croatian Medical Journal 57(2): 89-98.
- Silva, C.G. da; Rueda, F.; Lowik, C.W.; Ossendorp, F. & Cruz, L.J. (2016), Combinatorial prospects of nano-targeted chemoimmunotherapy, Biomaterials 83: 308-320.
- Kleinovink, J.W.; Driel, P.B. van; Snoeks, T.J.; Prokopi, N.; Fransen, M.F.; Cruz, L.J.; Mezzanotte, L.; Chan, A.; Lowik, C.W. & Ossendorp, F. (2016), Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors, Clinical Cancer Research 22(6): 1459-1468.
- Cruz, L.J.; Stammes, M.A.; Que, I.; Beek, E.R. van; Knol-Blankevoort, V.T.; Snoeks, T.J.A.; Chan, A.; Kaijzel, E.L. & Lowik, C.W.G.M. (2016), Effect of PLGA NP size on efficiency to target traumatic brain injury, Journal of Controlled Release 223: 31-41.
- Hawinkels, L.J.A.C.; Vinuesa, A.G. de; Paauwe, M.; Kruithof-de Julio, M.; Wiercinska, E.; Pardali, E.; Mezzanotte, L.; Keereweer, S.; Braumuller, T.M.; Heijkants, R.C.; Jonkers, J.; Lowik, C.W.; Goumans, M.J.; Hagen, T.L. ten & Dijke, P. ten (2016), Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors, Clinical Cancer Research 22(1): 96-106.
- van de Giessen Martijn, Schaafsma Boudewijn E., Charehbili Ayoub, Smit Vincent T. H. B. M., Kroep Judith R., Lelieveldt Boudewijn P. F., Liefers Gerrit-Jan, Chan Alan, Lowik Clemens W. G. M., Dijkstra Jouke, van de Velde Cornelis J. H., Wasser Martin N. J. M. & Vahrmeijer Alexander L. (2015), Early identification of non-responding locally advanced breast tumors receiving neoadjuvant chemotherapy, Proceedings of SPIE 9303.
- Schoeman, M.A.E.; Moester, M.J.C.; Oostlander, A.E.; Kaijzel, E.L.; Valstar, E.R.; Nelissen, R.G.H.H.; Lowik, C.W.G.M. & Rooij, K.E. de (2015), Inhibition of GSK3 Stimulates BMP Signaling and Decreases SOST Expression Which Results in Enhanced Osteoblast Differentiation, Journal of Cellular Biochemistry 116(12): 2938-2946.
- Liu, X.M.; Que, I.; Kong, X.G.; Zhang, Y.L.; Tu, L.P.; Chang, Y.L.; Wang, T.T.; Chan, A.; Lowik, C.W.G.M. & Zhang, H. (2015), In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform, Nanoscale 7(36): 14914-14923.
- Xie, B.W.; Stammes, M.A.; Driel, P.B.A.A. van; Cruz, L.J.; Knol-Blankevoort, V.T.; Lowik, M.A.M.; Mezzanotte, L.; Que, I.; Chan, A.; Wijngaard, J.P.H.M. van den; Siebes, M.; Gottschalk, S.; Razansky, D.; Ntziachristos, V.; Keereweer, S.; Horobin, R.W.; Hoehn, M.; Kaijzel, E.L.; Beek, E.R. van; Snoeks, T.J.A. & Lowik, C.W.G.M. (2015), Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models, Oncotarget 6(36): 39036-39049.
- Rooij, K.E. de; Velde, M. van der; Wilt, E. de; Deckers, M.M.L.; Bezemer, M.; Waarsing, J.H.; Que, I.; Chan, A.B.; Kaijzel, E.L. & Lowik, C.W.G.M. (2015), Identification of receptor-type protein tyrosine phosphatase mu as a new marker for osteocytes, Histochemistry and Cell Biology 144(1): 1-11.
- Sanches, P.G.; Peters, S.; Rossin, R.; Kaijzel, E.L.; Que, I.; Lowik, C.W.G.M. & Grull, H. (2015), Bone metastasis imaging with SPECT/CT/MRI: A preclinical toolbox for therapy studies, BONE 75: 62-71.
- Driel, P.B.A.A. van; Giessen, M. van de; Boonstra, M.C.; Snoeks, T.J.A.; Keereweer, S.; Oliveira, S.; Velde, C.J.H. van de; Lelieveldt, B.P.F.; Vahrmeijer, A.L.; Lowik, C.W.G.M. & Dijkstra, J. (2015), Characterization and Evaluation of the Artemis Camera for Fluorescence-Guided Cancer Surgery, Molecular Imaging and Biology 17(3): 413-423.
- Boonstra, M.C.; Driel, P.B.A.A. van; Willigen, D.M. van; Stammes, M.A.; Prevoo, H.A.J.M.; Tummers, Q.R.J.G.; Mazar, A.P.; Beekman, F.J.; Kuppen, P.J.K.; Velde, C.J.H. van de; Lowik, C.W.G.M.; Frangioni, J.V.; Leeuwen, F.W.B. van; Sier, C.F.M. & Vahrmeijer, A.L. (2015), uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery, Oncotarget 6(16): 14260-14273.
- Slooter, M.D.; Bierau, K.; Chan, A.B. & Lowik, C.W.G.M. (2015), Near Infrared Fluorescence Imaging for early detection, monitoring and improved intervention of diseases involving the joint, Connective Tissue Research 56(2): 153-160.
- Kraan, H.; Ploemen, I.; Wijdeven, G. van de; Que, I.; Lowik, C.; Kersten, G. & Amorij, J.P. (2015), Alternative delivery of a thermostable inactivated polio vaccine, Vaccine 33(17): 2030-2037.
- Rosalia, R.A.; Cruz, L.J.; Duikeren, S. van; Tromp, A.T.; Silva, A.L.; Jiskoot, W.; Gruijl, T. de; Lowik, C.; Oostendorp, J.; Burg, S.H. van der & Ossendorp, F. (2015), CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses, Biomaterials 40: 88-97.
- Rahimian, S.; Kleinovink, J.W.; Fransen, M.F.; Mezzanotte, L.; Gold, H.; Wisse, P.; Overkleeft, H.; Amidi, M.; Jiskoot, W.; Lowik, C.W.; Ossendorp, F. & Hennink, W.E. (2015), Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8+ T cell immune response, Biomaterials 37: 469-477.
- Verbeek, F.P.R.; Vorst, J.R. van der; Tummers, Q.R.J.G.; Boonstra, M.C.; Rooij, K.E. de; Lowik, C.W.G.M.; Valentijn, A.R.P.M.; Velde, C.J.H. van de; Choi, H.S.; Frangioni, J.V. & Vahrmeijer, A.L. (2014), Near-Infrared Fluorescence Imaging of Both Colorectal Cancer and Ureters Using a Low-Dose Integrin Targeted Probe, Annals of Surgical Oncology 21: S528-S537.
- Pedro, G.S.; Muhlmeister, M.; Seip, R.; Kaijzel, E.; Lowik, C.; Bohmer, M.; Tiemann, K. & Grull, H. (2014), Ultrasound-mediated gene delivery of naked plasmid DNA in skeletal muscles: A case for bolus injections, Journal of Controlled Release 195: 130-137.
- Roos, A.; Tan, J.V.F.; Driel, P.B.A.A. van; Snocks, T.J.A.; Vliet, M. van & Lowik, C.W.G.M. (2014), PHOTODYNAMIC THERAPY IN CANINE AND FELINE CANCER TREATMENT USING THE PHOTOSENSITIZER BREMACHLORIN, Anticancer Research 34(10): 6139-6139.
- Cruz, L.J.; Rosalia, R.A.; Kleinovink, J.W.; Rueda, F.; Lowik, C.W.G.M. & Ossendorp, F. (2014), Targeting nanoparticles to CD40, DEC-205 or CD11c molecules on dendritic cells for efficient CD8(+) T cell response: A comparative study, Journal of Controlled Release 192: 209-218.
- Mezzanotte, L.; Blankevoort, V.; Lowik, C.W.G.M. & Kaijzel, E.L. (2014), A novel luciferase fusion protein for highly sensitive optical imaging: from single-cell analysis to in vivo whole-body bioluminescence imaging, Analytical and Bioanalytical Chemistry 406(23): 5727-5734.
- Dzyubachyk, O.; Khmelinskii, A.; Plenge, E.; Kok, P.; Snoeks, T.J.A.; Poot, D.H.J.; Lowik, C.W.G.M.; Botha, C.P.; Niessen, W.J.; Weerd, L. van der; Meijering, E. & Lelieveldt, B.P.F. (2014), Interactive Local Super-Resolution Reconstruction of Whole-Body MRI Mouse Data: A Pilot Study with Applications to Bone and Kidney Metastases, PLoS ONE 9(9).
- Adamczak, J.M.; Schneider, G.; Nelles, M.; Que, I.; Suidgeest, E.; Weerd, L. van der; Lowik, C. & Hoehn, M. (2014), In vivo bioluminescence imaging of vascular remodeling after stroke, Frontiers in Cellular Neuroscience 8.
- Driel, P.B.A.A. van; Vorst, J.R. van der; Verbeek, F.P.R.; Oliveira, S.; Snoeks, T.J.A.; Keereweer, S.; Chan, B.; Boonstra, M.C.; Frangioni, J.V.; Bergen en Henegouwen, P.M.P. van; Vahrmeijer, A.L. & Lowik, C.W.G.M. (2014), Intraoperative fluorescence delineation of head and neck cancer with a fluorescent Anti- epidermal growth factor receptor nanobody, International Journal of Cancer 134(11): 2663-2673.
- Snoeks, T.J.A.; Driel, P.B.A.A. van; Keereweer, S.; Aime, S.; Brindle, K.M.; Dam, G.M. van; Lowik, C.W.G.M.; Ntziachristos, V. & Vahrmeijer, A.L. (2014), Towards a Successful Clinical Implementation of Fluorescence-Guided Surgery, Molecular Imaging and Biology 16(2): 147-151.
- Leeuwen-van Zaane, F. van; Driel, P.B.A.A. van; Gamm, U.A.; Snoeks, T.J.A.; Bruijn, H.S. de; Ploeg-van den Heuvel, A. van der; Lowik, C.W.G.M.; Sterenborg, H.J.C.M.; Amelink, A. & Robinson, D.J. (2014), Microscopic analysis of the localization of two chlorin-based photosensitizers in OSC19 tumors in the mouse oral cavity, Lasers in Surgery and Medicine 46(3): 224-234.
- Boehm-Sturm, P.; Aswendt, M.; Minassian, A.; Michalk, S.; Mengler, L.; Adamczak, J.; Mezzanotte, L.; Lowik, C. & Hoehn, M. (2014), A multi-modality platform to image stem cell graft survival in the naive and stroke-damaged mouse brain, Biomaterials 35(7): 2218-2226.
- Fagerlund, K.; Habilainen-Kirillov, N.; Lowik, C.; Chan, A. & Halleen, J. (2014), An in Vitro Chondrogenic Differentiation Model Using KS483 Mouse Mesenchymal Progenitor Cell Line, Journal of Bone and Mineral Research 29: S377-S378.
- Keereweer, S.; Driel, P.B.A.A. van & Lowik, C.W.G.M. (2014), Preclinical Studies on Tumor-Specific Fluorescent Targeting Agents: the Need for a Gold Standard of Tumor Localization, Molecular Imaging and Biology 16(1): 10-12.
- Keereweer, S.; Driel, P.B.A.A. van; Robinson, D.J. & Lowik, C.W.G.M. (2014), Shifting Focus in Optical Image-Guided Cancer Therapy.
- Filipe Vasco, Que Ivo, Carpenter John F., Lowik Clemens & Jiskoot Wim (2014), In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice, PHARMACEUTICAL RESEARCH 31(1): 216-227.
- Leeuwen-van Zaane, F. van; Gamm, U.A.; Driel, P.B.A.A. van; Snoeks, T.J.; Bruijn, H.S. de; Ploeg-van den Heuvel, A. van der; Sterenborg, H.J.C.M.; Lowik, C.W.; Amelink, A. & Robinson, D.J. (2014), Intrinsic photosensitizer fluorescence measured using multi-diameter single-fiber spectroscopy in vivo.
- Filipe, V.; Que, I.; Carpenter, J.F.; Lowik, C. & Jiskoot, W. (2014), In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice, Pharmaceutical Research 31(1): 216-227.
- Mezzanotte, L.; An, N.; Mol, I.M.; Lowik, C.W.G.M. & Kaijzel, E.L. (2014), A New Multicolor Bioluminescence Imaging Platform to Investigate NF-kappa B Activity and Apoptosis in Human Breast Cancer Cells, PLoS ONE 9(1).
- Moester, M.J.C.; Schoeman, M.A.E.; Oudshoorn, I.B.; Beusekom, M.M. van; Mol, I.M.; Kaijzel, E.L.; Lowik, C.W.G.M. & Rooij, K.E. de (2014), Validation of a simple and fast method to quantify in vitro mineralization with fluorescent probes used in molecular imaging of bone, Biochemical and Biophysical Research Communications 443(1): 80-85.
- Mezzanotte, L.; Aswendt, M.; Tennstaedt, A.; Hoeben, R.; Hoehn, M. & Lowik, C. (2013), Evaluating reporter genes of different luciferases for optimized in vivo bioluminescence imaging of transplanted neural stem cells in the brain, Contrast Media and Molecular Imaging 8(6): 505-513.
- Park, D.; Xie, B.W.; Beek, E.R. van; Blankevoort, V.; Que, I.; Lowik, C.W.G.M. & Hogg, P.J. (2013), Optical Imaging of Treatment-Related Tumor Cell Death Using a Heat Shock Protein-90 Alkylator, Molecular Pharmaceutics 10(10): 3882-3891.
- Vorst, J.R. van der; Schaafsma, B.E.; Hutteman, M.; Verbeek, F.P.R.; Liefers, G.J.; Hartgrink, H.H.; Smit, V.T.H.B.M.; Lowik, C.W.G.M.; Velde, C.J.H. van de; Frangioni, J.V. & Vahrmeijer, A.L. (2013), Near-infrared fluorescence-guided resection of colorectal liver metastases, Cancer 119(18): 3411-3418.
- Keereweer, S.; Driel, P.B.A.A. van; Snoeks, T.J.A.; Kerrebijn, J.D.F.; Jong, R.J.B. de; Vahrmeijer, A.L.; Sterenborg, H.J.C.M. & Lowik, C.W.G.M. (2013), Optical Image-Guided Cancer Surgery: Challenges and Limitations, Clinical Cancer Research 19(14): 3745-3754.
- Locher, H.; Rooij, K.E. de; Groot, J.C.M.J. de; Doorn, R. van; Gruis, N.A.; Lowik, C.W.G.M.; Lopes, S.M.C.D.; Frijns, J.H.M. & Huisman, M.A. (2013), Class III beta-tubulin, a novel biomarker in the human melanocyte lineage, Differentiation 85(4-5): 173-181.
- Leeuwen-van Zaane, F. van; Gamm, U.A.; Driel, P.B.A.A. van; Snoeks, T.J.A.; Bruijn, H.S. de; Ploeg-van den Heuvel, A. van der; Mol, I.M.; Lowik, C.W.G.M.; Sterenborg, H.J.C.M.; Amelink, A. & Robinson, D.J. (2013), In vivo quantification of the scattering properties of tissue using multi-diameter single fiber reflectance spectroscopy, Biomedical Optics Express 4(5): 696-708.
- Adel, B. den; Graaf, L.M. van der; Que, I.; Strijkers, G.J.; Lowik, C.W.; Poelmann, R.E. & Weerd, L. van der (2013), Contrast enhancement by lipid-based MRI contrast agents in mouse atherosclerotic plaques; a longitudinal study, Contrast Media and Molecular Imaging 8(1): 63-71.
- Vorst, J.R. van der; Schaafsma, B.E.; Verbeek, F.P.R.; Keereweer, S.; Jansen, J.C.; Velden, L.A. van der; Langeveld, A.P.M.; Hutteman, M.; Lowik, C.W.G.M.; Velde, C.J.H. van de; Frangioni, J.V. & Vahrmeijer, A.L. (2013), Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients, Oral Oncology 49(1): 15-19.
- Xie, B.W.; Park, D.; Beek, E.R. van; Blankevoort, V.; Orabi, Y.; Que, I.; Kaijzel, E.L.; Chan, A.; Hogg, P.J. & Lowik, C.W.G.M. (2013), Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator.
- Snoeks TJ, van Beek E, Que I, Kaijzel EL & Löwik CW (2012), Bioluminescence imaging of bone metastasis in rodents., Methods in Molecular Biology 816: 507-15.
- Xie, B.W.; Mol, I.M.; Keereweer, S.; Beek, E.R. van; Que, I.; Snoeks, T.J.A.; Chan, A.; Kaijzel, E.L. & Lowik, C.W.G.M. (2012), Dual-wavelength imaging of tumor progression by activatable and targeting near-infrared fluorescent probes in a bioluminescent breast cancer model., PLoS ONE 7(2): e31875.
- Vorst, J.R. van der; Schaafsma, B.E.; Verbeek, F.P.R.; Hutteman, M.; Mieog, J.S.D.; Lowik, C.W.G.M.; Liefers, G.J.; Frangioni, J.V.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2012), Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and 99(m) Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients, Annals of Surgical Oncology 19(13): 4104-4111.
- Vries, M.R. de; Niessen, H.W.M.; Lowik, C.W.G.M.; Hamming, J.F.; Jukema, J.W. & Quax, P.H.A. (2012), Plaque Rupture Complications in Murine Atherosclerotic Vein Grafts Can Be Prevented by TIMP-1 Overexpression, PLoS ONE 7(10): -.
- Baiker, M.; Snoeks, T.J.A.; Kaijzel, E.L.; Que, I.; Dijkstra, J.; Lelieveldt, B.P.F. & Lowik, C.W.G.M. (2012), Automated Bone Volume and Thickness Measurements in Small Animal Whole-Body MicroCT Data, Molecular Imaging and Biology 14(4): 420-430.
- Smith, B.A.; Xie, B.W.; Beek, E.R. van; Que, I.; Blankevoort, V.; Xiao, S.Z.; Cole, E.L.; Hoehn, M.; Kaijzel, E.L.; Lowik, C.W.G.M. & Smith, B.D. (2012), Multicolor Fluorescence Imaging of Traumatic Brain Injury in a Cryolesion Mouse Model, ACS Chemical Neuroscience 3(7): 530-537.
- Keereweer, S.; Mol, I.M.; Kerrebijn, J.D.F.; Driel, P.B.A.A. van; Xie, B.W.; Jong, R.J.B. de; Vahrmeijer, A.L. & Lowik, C.W.G.M. (2012), Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer, Journal of Surgical Oncology 105(7): 714-718.
- Velde, M. van der; Theewsen, J.; Jamon, M.; Vico, L.; Laroche, N.; Lowik, C.W. & Rooij, K.E. de (2012), The role of RPTP mu and sclerostin in bone mechanosensing and regulation of bone formation, BONE 50: S63-S64.
- Moester, M.J.C.; Beusekom, M.M. van; Mol, I.M.; Lowik, C.W.G.M. & Rooij, K.E. de (2012), Validation of an easy new method to quantify in vitro mineralization using Bonetag or Osteosense, BONE 50: S79-S80.
- Mezzanotte, L.; An, N.; Kaijzel, E. & Lowik, C. (2012), Development of a triple color bioluminescent breast cancer cell line for high content analysis, Luminescence 27(2): 140-141.
- Xie, B.W.; Mol, I.M.; Keereweer, S.; Beek, E.R. van; Que, I.; Snoeks, T.J.A.; Chan, A.; Kaijzel, E.L. & Lowik, C.W.G.M. (2012), Dual-Wavelength Imaging of Tumor Progression by Activatable and Targeting Near-Infrared Fluorescent Probes in a Bioluminescent Breast Cancer Model, PLoS ONE 7(2).
- Keereweer, S.; Sterenborg, H.J.C.M.; Kerrebijn, J.D.F.; Driel, P.B.A.A. van; Jong, R.J.B. de & Lowik, C.W.G.M. (2012), IMAGE-GUIDED SURGERY IN HEAD AND NECK CANCER: CURRENT PRACTICE AND FUTURE DIRECTIONS OF OPTICAL IMAGING, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 34(1): 120-126.
- Hutteman, M.; Vorst, J.R. van der; Gaarenstroom, K.N.; Peters, A.A.W.; Mieog, J.S.D.; Schaafsma, B.E.; Lowik, C.W.G.M.; Frangioni, J.V.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2012), Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer, American Journal of Obstetrics and Gynecology 206(1): -.
- Keereweer, S.; Mol, I.M.; Vahrmeijer, A.L.; Driel, P.B.A.A. van; Jong, R.J.B. de; Kerrebijn, J.D.F. & Lowik, C.W.G.M. (2012), Dual wavelength tumor targeting for detection of hypopharyngeal cancer using near-infrared optical imaging in an animal model., International Journal of Cancer.
- Keereweer, S.; Hutteman, M.; Kerrebijn, J.D.F.; Velde, C.J.H. van de; Vahrmeijer, A.L. & Lowik, C.W.G.M. (2012), Translational Optical Imaging in Diagnosis and Treatment of Cancer., Current Pharmaceutical Biotechnology.
- Baiker M, Staring M, Lowik CWGM, Reiber JHC & Lelieveldt BPF (2011), Automated Registration of Whole-Body Follow-Up MicroCT Data of Mice, MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION (MICCAI 2011), PT II 6892: 516-523.
- Hutteman, M.; Vorst, J.R. van der; Mieog, J.S.D.; Bonsing, B.A.; Hartgrink, H.H.; Kuppen, P.J.K.; Lowik, C.W.G.M.; Frangioni, J.V.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2011), Near-Infrared Fluorescence Imaging in Patients Undergoing Pancreaticoduodenectomy.
- Snoeks, T.J.A.; Kaijzel, E.L.; Que, I.; Mol, I.M.; Lowik, C.W.G.M. & Dijkstra, J. (2011), Normalized volume of interest selection and measurement of bone volume in MicroCT scans, BONE 49(6): 1264-1269.
- Lelieveldt BPF, Botha CP, Kaijzel EL, Hendriks EA, Reiber JHC, Lowik CWGM & Dijkstra J (2011), TOWARDS INTEGRATED ANALYSIS OF LONGITUDINAL WHOLE-BODY SMALL ANIMAL IMAGING STUDIES, 2011 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING: 5768-5771.
- Miclea, R.L.; Siebelt, M.; Finos, L.; Goeman, J.J.; Lowik, C.W.G.M.; Oostdijk, W.; Weinans, H.; Wit, J.M.; Robanus-Maandag, E.C. & Karperien, M. (2011), Inhibition of Gsk3 beta in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway, Osteoarthritis and Cartilage 19(11): 1363-1372.
- Miclea, R.L.; Siebelt, M.; Finos, L.; Goeman, J.J.; Lowik, C.W.G.M.; Oostdijk, W.; Weinans, H.; Wit, J.M.; Robanus-Maandag, E.C. & Karperien, M. (2011), Inhibition of Gsk3β in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway., Osteoarthritis and Cartilage 19(11): 1363-72.
- Baiker, M.; Snoeks, T.J.A.; Kaijzel, E.L.; Que, I.; Dijkstra, J.; Lelieveldt, B.P.F. & Lowik, C.W.G.M. (2011), Automated Bone Volume and Thickness Measurements in Small Animal Whole-Body MicroCT Data.
- Keereweer, S.; Kerrebijn, J.D.F.; Mol, I.M.; Mieog, J.S.D.; Driel, P.B.A.A. van; Jong, R.J.B. de; Vahrmeijer, A.L. & Lowik, C.W.G.M. (2011), Optical imaging of oral squamous cell carcinoma and cervical lymph node metastasis., Head and Neck.
- Mieog, J.S.D.; Troyan, S.L.; Hutteman, M.; Donohoe, K.J.; Vorst, J.R. van der; Stockdale, A.; Liefers, G.J.; Choi, H.S.; Gibbs-Strauss, S.L.; Putter, H.; Gioux, S.; Kuppen, P.J.K.; Ashitate, Y.; Lowik, C.W.G.M.; Smit, V.T.H.B.M.; Oketokoun, R.; Ngo, L.H.; Velde, C.J.H. van de; Frangioni, J.V. & Vahrmeijer, A.L. (2011), Toward Optimization of Imaging System and Lymphatic Tracer for Near-Infrared Fluorescent Sentinel Lymph Node Mapping in Breast Cancer, Annals of Surgical Oncology 18(9): 2483-2491.
- Schaafsma, B.E.; Mieog, J.S.D.; Hutteman, M.; Vorst, J.R. van der; Kuppen, P.J.K.; Lowik, C.W.G.M.; Frangioni, J.V.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2011), The Clinical Use of Indocyanine Green as a Near-Infrared Fluorescent Contrast Agent for Image-Guided Oncologic Surgery, Journal of Surgical Oncology 104(3): 323-332.
- Schaafsma, B.E.; Mieog, J.S.D.; Hutteman, M.; Vorst, J.R. van der; Kuppen, P.J.K.; Lowik, C.W.G.M.; Frangioni, J.V.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2011), The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery., Journal of Surgical Oncology 104(3): 323-32.
- Mieog, J.S.D.; Hutteman, M.; Vorst, J.R. van der; Kuppen, P.J.K.; Que, I.; Dijkstra, J.; Kaijzel, E.L.; Prins, F.; Lowik, C.W.G.M.; Smit, V.T.H.B.M.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2011), Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer, Breast Cancer Research and Treatment 128(3): 679-689.
- Keereweer, S.; Mol, I.M.; Kerrebijn, J.D.F.; Driel, P.B.A.A. van; Xie, B.W.; Jong, R.J.B. de; Vahrmeijer, A.L. & Lowik, C.W.G.M. (2011), Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer, Oral Oncology 47: S70-S71.
- Keereweer, S.; Mieog, J.S.D.; Mol, I.M.; Driel, P.B.A.A. van; Snoeks, T.J.A.; Jong, R.J.B. de; Vahrmeijer, A.L.; Kerrebijn, J.D.F. & Lowik, C.W.G.M. (2011), Detection of Oral Squamous Cell Carcinoma and Cervical Lymph Node Metastasis Using Activatable Near-Infrared Fluorescence Agents.
- Miclea, R.L.; Horst, G. van der; Robanus-Maandag, E.C.; Lowik, C.W.G.M.; Oostdijk, W.; Wit, J.M. & Karperien, M. (2011), Apc bridges Wnt/beta-catenin and BMP signaling during osteoblast differentiation of 16483 cells, Experimental Cell Research 317(10): 1411-1421.
- Miclea, R.L.; Horst, G. van der; Robanus-Maandag, E.C.; Lowik, C.W.G.M.; Oostdijk, W.; Wit, J.M. & Karperien, M. (2011), Apc bridges Wnt/β-catenin and BMP signaling during osteoblast differentiation of KS483 cells., Experimental Cell Research 317(10): 1411-21.
- Snoeks, T.J.A.; Mol, I.M.; Que, I.; Kaijzel, E.L. & Lowik, C.W.G.M. (2011), 2-Methoxyestradiol Analogue ENMD-1198 Reduces Breast Cancer-Induced Osteolysis and Tumor Burden Both In Vitro and In Vivo, Molecular Cancer Therapeutics 10(5): 874-882.
- Hutteman, M.; Mieog, J.S.D.; Vorst, J.R. van der; Liefers, G.J.; Putter, H.; Lowik, C.W.G.M.; Frangioni, J.V.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2011), Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients, Breast Cancer Research and Treatment 127(1): 163-170.
- Keereweer, S.; Kerrebijn, J.D.F.; Driel, P.B.A.A. van; Xie, B.W.; Kaijzel, E.L.; Snoeks, T.J.A.; Que, I.; Hutteman, M.; Vorst, J.R. van der; Mieog, J.S.D.; Vahrmeijer, A.L.; Velde, C.J.H. van de; Jong, R.J.B. de & Lowik, C.W.G.M. (2011), Optical Image-guided Surgery-Where Do We Stand?, Molecular Imaging and Biology 13(2): 199-207.
- Mezzanotte, L.; Que, I.; Kaijzel, E.; Branchini, B.; Roda, A. & Lowik, C. (2011), Sensitive Dual Color In Vivo Bioluminescence Imaging Using a New Red Codon Optimized Firefly Luciferase and a Green Click Beetle Luciferase, PLoS ONE 6(4): -.
- Klose, A.; Waerzeggers, Y.; Monfared, P.; Vukicevic, S.; Kaijzel, E.L.; Winkeler, A.; Wickenhauser, C.; Lowik, C.W.G.M. & Jacobs, A.H. (2011), Imaging Bone Morphogenetic Protein 7 Induced Cell Cycle Arrest in Experimental Gliomas, Neoplasia 13(3): 276-U123.
- Hutteman, M.; Mieog, J.S.D.; Vorst, J.R. van der; Dijkstra, J.; Kuppen, P.J.K.; Laan, A.M.A. van der; Tanke, H.J.; Kaijzel, E.L.; Que, I.; Velde, C.J.H. van de; Lowik, C.W.G.M. & Vahrmeijer, A.L. (2011), Intraoperative near-infrared fluorescence imaging of colorectal metastases targeting integrin alpha(v)beta(3) expression in a syngeneic rat model, EJSO - European Journal of Surgical Oncology 37(3): 252-257.
- Vorst, J.R. van der; Hutteman, M.; Mieog, J.S.D.; Rooij, K.E. de; Kaijzel, E.L.; Lowik, C.W.G.M.; Putter, H.; Kuppen, P.J.K.; Frangioni, J.V.; Velde, C.J.H. van de & Vahrmeijer, A.L. (2011), Near-Infrared Fluorescence Imaging of Liver Metastases in Rats using Indocyanine Green., Journal of Surgical Research.
- Hutteman, M.; Mieog, J.S.D.; Vorst, J.R. van der; Dijkstra, J.; Kuppen, P.J.K.; Laan, A.M.A. van der; Tanke, H.J.; Kaijzel, E.L.; Que, I.; Velde, C.J.H. van de; Lowik, C.W.G.M. & Vahrmeijer, A.L. (2011), Intraoperative near-infrared fluorescence imaging of colorectal metastases targeting integrin α(v)β(3) expression in a syngeneic rat model.
- Snoeks, T.J.A.; Khmelinskii, A.; Que, I.; Lelieveldt, B.; Kaijzel, E.L. & Lowik, C.W.G.M. (2011), A method to follow tumor growth and tumor induced bone loss simultaneously over time, in vivo, using whole body bioluminescence fluorescence imaging, BONE 48(1): S49-S50.
- Snoeks, T.J.A.; Khmelinskii, A.; Lelieveldt, B.P.F.; Kaijzel, E.L. & Lowik, C.W.G.M. (2011), Optical advances in skeletal imaging applied to bone metastases, BONE 48(1): 106-114.
- Snoeks, T.J.A.; Khmelinskii, A.; Lelieveldt, B.P.F.; Kaijzel, E.L. & Lowik, C.W.G.M. (2011), Optical advances in skeletal imaging applied to bone metastases., BONE 48(1): 106-14.
- Slutter, B.; Bal, S.M.; Que, I.; Kaijzel, E.; Lowik, C.; Bouwstra, J. & Jiskoot, W. (2010), Antigen-Adjuvant Nanoconjugates for Nasal Vaccination: An Improvement over the Use of Nanoparticles?, Molecular Pharmaceutics 7(6): 2207-2215.
- Kok, P.; Baiker, M.; Hendriks, E.A.; Post, F.H.; Dijkstra, J.; Lowik, C.W.G.M.; Lelieveldt, B.P.F. & Botha, C.P. (2010), Articulated Planar Reformation for Change Visualization in Small Animal Imaging, IEEE Transactions on Visualization and Computer Graphics 16(6): 1396-1404.
- Baiker, M.; Milles, J.; Dijkstra, J.; Henning, T.D.; Weber, A.W.; Que, I.; Kaijzel, E.L.; Lowik, C.W.G.M.; Reiber, J.H.C. & Lelieveldt, B.P.F. (2010), Atlas-based whole-body segmentation of mice from low-contrast Micro-CT data, Medical Image Analysis 14(6): 723-737.
- Krause, C.; Korchynskyi, O.; Rooij, K. de; Weidauer, S.E.; Gorter, D.J.J. de; Bezooijen, R.L. van; Hatsell, S.; Economides, A.N.; Mueller, T.D.; Lowik, C.W.G.M. & Dijke, P. ten (2010), Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways., Journal of Biological Chemistry 285(53): 41614-26.
- Hellingman, A.A.; Bastiaansen, A.J.N.M.; Vries, M.R. de; Seghers, L.; Lijkwan, M.A.; Lowik, C.W.; Hamming, J.F. & Quax, P.H.A. (2010), Variations in Surgical Procedures for Hind Limb Ischaemia Mouse Models Result in differences in Collateral Formation.
- Hutteman, M.; Choi, H.S.; Mieog, J.S.D.; Vorst, J.R. van der; Ashitate, Y.; Kuppen, P.J.K.; Groningen, M.C. van; Lowik, C.W.G.M.; Smit, V.T.H.B.M.; Velde, C.J.H. van de; Frangioni, J.V. & Vahrmeijer, A.L. (2010), Clinical Translation of Ex Vivo Sentinel Lymph Node Mapping for Colorectal Cancer Using Invisible Near-Infrared Fluorescence Light.
- Kaijzel, E.L.; Heijningen, P.M. van; Wielopolski, P.A.; Vermeij, M.; Koning, G.A.; Cappellen, W.A. van; Que, I.; Chan, A.; Dijkstra, J.; Ramnath, N.W.M.; Hawinkels, L.J.A.C.; Bernsen, M.R.; Lowik, C.W.G.M. & Essers, J. (2010), Multimodality Imaging Reveals a Gradual Increase in Matrix Metalloproteinase Activity at Aneurysmal Lesions in Live Fibulin-4 Mice, Circulation: Cardiovascular Imaging 3(5): 567-577.
- Kruttwig, K.; Brueggemann, C.; Kaijzel, E.; Vorhagen, S.; Hilger, T.; Lowik, C. & Hoehn, M. (2010), Development of a Three-Dimensional In Vitro Model for Longitudinal Observation of Cell Behavior: Monitoring by Magnetic Resonance Imaging and Optical Imaging, Molecular Imaging and Biology 12(4): 367-376.
- Slutter, B.; Bal, S.; Keijzer, C.; Mallants, R.; Hagenaars, N.; Que, I.; Kaijzel, E.; Eden, W. van; Augustijns, P.; Lowik, C.; Bouwstra, J.; Broere, F. & Jiskoot, W. (2010), Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: Nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen, Vaccine 28(38): 6282-6291.
- Mieog, J.S.D.; Vahrmeijer, A.L.; Hutteman, M.; Vorst, J.R. van der; Hooff, M.D. van; Dijkstra, J.; Kuppen, P.J.K.; Keijzer, R.; Kaijzel, E.L.; Que, I.; Velde, C.J.H. van de & Lowik, C.W.G.M. (2010), Novel Intraoperative Near-Infrared Fluorescence Camera System for Optical Image-Guided Cancer Surgery, Molecular Imaging 9(4): 223-231.
- Power, J.; Poole, K.E.S.; Bezooijen, R. van; Doube, M.; Caballero-Alias, A.M.; Lowik, C.; Papapoulos, S.; Reeve, J. & Loveridge, N. (2010), Sclerostin and the Regulation of Bone Formation: Effects in Hip Osteoarthritis and Femoral Neck Fracture, Journal of Bone and Mineral Research 25(8): 1867-1876.
- Moester, M.J.C.; Papapoulos, S.E.; Lowik, C.W.G.M. & Bezooijen, R.L. van (2010), Sclerostin: Current Knowledge and Future Perspectives, Calcified Tissue International 87(2): 99-107.
- Piters, E.; Culha, C.; Moester, M.; Bezooijen, R. van; Adriaensen, D.; Mueller, T.; Weidauer, S.; Jennes, K.; Freitas, F. de; Lowik, C.; Timmermans, J.P.; Hul, W. van & Papapoulos, S. (2010), First Missense Mutation in the SOST Gene Causing Sclerosteosis by Loss of Sclerostin Function, Human Mutation 31(7): E1526E1543.
- Snoeks, T.J.A.; Lowik, C.W.G.M. & Kaijzel, E.L. (2010), 'In vivo' optical approaches to angiogenesis imaging, Angiogenesis 13(2): 135-147.
- Hagenaars, N.; Mania, M.; Jong, P. de; Que, I.; Nieuwland, R.; Slutter, B.; Glansbeek, H.; Heldens, J.; Bosch, H. van den; Lowik, C.; Kaijzel, E.; Mastrobattista, E. & Jiskoot, W. (2010), Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine, Journal of Controlled Release 144(1): 17-24.
- Wijngaarden, J. van; Snoeks, T.J.A.; Beek, E. van; Bloys, H.; Kaijzel, E.L.; Hinsbergh, V.W.M. van & Lowik, C.W.G.M. (2010), An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: Actions of TNP-470, marimastat and the tubulin-binding agent Ang-510, Biochemical and Biophysical Research Communications 391(2): 1161-1165.
- van Beek ER, Lowik CWGM, van Wijngaarden J, Ebetino FH & Papapoulos SE (2009), Synergistic effect of bisphosphonate and docetaxel on the growth of bone metastasis in an animal model of established metastatic bone disease, Breast Cancer Research and Treatment 118(2): 307-313.
- Ploemen IHJ, Prudencio M, Douradinha BG, Ramesar J, Fonager J, van Gemert GJ, Luty AJF, Hermsen CC, Sauerwein RW, Baptista FG, Mota MM, Waters AP, Que I, Lowik CWGM, Khan SM, Janse CJ & Franke-Fayard BMD (2009), Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging, PLoS ONE 4(11).
- Laurens N, Engelse MA, Jungerius C, Lowik CW, van Hinsbergh VWM & Koolwijk P (2009), Single and combined effects of alpha v beta 3-and alpha 5 beta 1-integrins on capillary tube formation in a human fibrinous matrix, Angiogenesis 12(3): 275-285.
- Liu Z, Kobayashi K, van Dinther M, van Heiningen SH, Valdimarsdottir G, van Laar T, Scharpfenecker M, Lowik CWGM, Goumans MJ & ten Dijke P (2009), VEGF and inhibitors of TGF beta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha 5-integrin expression, Journal of Cell Science 122(18): 3294-3302.
- van Bezooijen RL, Bronckers AL, Gortzak RA, Hogendoorn PCW, van der Wee-Pals L, Balemans W, Oostenbroek HJ, Van Hul W, Hamersma H, Dikkers FG, Hamdy NAT, Papapoulos SE & Lowik CWGM (2009), Sclerostin in Mineralized Matrices and van Buchem Disease, Journal of Dental Research 88(6): 569-574.
- Kaijzel EL, Snoeks TJA, Buijs JT, van der Pluijm G & Lowik CWGM (2009), Multimodal imaging and treatment of bone metastasis, Clinical and Experimental Metastasis 26(4): 371-379.
- Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akcakaya P & Lowik CWGM (2009), Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors, BMC Developmental Biology 9.
- Carpusca I, Mergui S, Jacobs A, Aime S & Loewik C (2009), EMIL European network in cancer molecular imagery, Biofutur: 59-62.
- Mulder WJM, Castermans K, van Beijnum JR, Egbrink MGAO, Chin PTK, Fayad ZA, Lowik CWGM, Kaijzel EL, Que I & Storm G (2009), Molecular imaging of tumor angiogenesis using alpha v beta 3-integrin targeted multimodal quantum dots, Angiogenesis 12(1): 17-24.
- Buijs JT, Que I, Lowik CWGM, Papapoulos SE & van der Pluijm G (2009), Inhibition of bone resorption and growth of breast cancer in the bone microenvironment, BONE 44(2): 380-386.
- Baiker M, Dijstra J, Que I, Lowik CWGM, Reiber JHC & Lelieveldt BPF (2008), Organ approximation in mu CT data with low soft tissue contrast using an articulated whole-body atlas, 2008 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO, VOLS 1-4: 1267-1270.
- El Seady R, Huisman MA, Lowik CWGM & Frijns JHM (2008), Uncomplicated differentiation of stem cells into bipolar neurons and myelinating glia, Biochemical and Biophysical Research Communications 376(2).
- de Rooij K. E., Waarsing E., de Wilt E., Que I., Mass M. M. L. Bone & Loewik C. W. G. M. (2008), In Bone, RPTP mu Is Exclusively Expressed in Osteocytes and May Affect Bone Mass.
- Hillen F, Kaijzel EL, Castermans K, Egbrink MGAO, Lowik CWGM & Griffioen AW (2008), A transgenic Tie2-GFP athymic mouse model; a tool for vascular biology in xenograft tumors, Biochemical and Biophysical Research Communications 368(2).
- ten Dijke P, Krause C, de Gorter DJJ, Lowik CWGM & van Bezooijen RL (2008), Osteocyte-derived sclerostin inhibits bone formation: Its role in bone morphogenetic protein and Wnt signaling, Journal of Bone and Joint Surgery, American Volume 90A.
- Baiker M, Milles J, Vossepoell AM, Que I, Kaijzel EL, Lowik CWGM, Reiber JHC, Dykstra J & Lelieveldt BPF (2007), Fully automated whole-body registration in mice using an articulated skeleton atlas, 2007 4TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING : MACRO TO NANO, VOLS 1-3: 728-731.
- Kok P, Dijkstra J, Botha CP, Post FH, Kaijzel E, Quec I, Lowik CWGM, Reiber JHC & Lelieveldt BPF (2007), Integrated visualization of multi-angle bioluminescence imaging and micro CT - art. no. 65091U, Medical Imaging 2007: Visualization and Image-Guided Procedures, Pts 1 and 2 6509: U5091-U5091.
- Henriquez NV, van Overveld PGM, Que I, Buijs JT, Bachelier R, Kaijzel EL, Lowik CWGM, Clezardin P & van der Pluijm G (2007), Advances in optical imaging and novel model systems for cancer metastasis research, Clinical and Experimental Metastasis 24(8).
- Notting, I.; Buijs, J.; Mintardjo, R.; Horst, G. van der; Vukicevic, S.; Lowik, C.; Schalij-Delfos, N.; Keunen, J. & Pluijm, G. van der (2007), Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo, Investigative Ophthalmology & Visual Science 48(11).
- Buijs JT, Rentsch CA, van der Horst G, van Civerveld PGM, Wetterwald A, Schwaninger R, Henriquez NV, ten Dijke P, Borovecki F, Markwalder R, Thalmann GN, Papapoulos SE, Pelger RCM, Vukicevic S, Cecchini MG, Lowik CWGM & van der Pluijm G (2007), BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo, American Journal of Pathology 171(3).
- Eefting D, Grimbergen JM, De Vries MR, Van Weel V, Kaijzel EL, Que I, Moon RT, Lowik CW, Van Bockel JH & Quax PHA (2007), Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA, Human Gene Therapy 18(9).
- Buijs JT, Henriquez NV, Van Overveld PGM, Van der Horst G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, Cleton-Jansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clezardin P, Papapoulos SE, Cecchini MG, Lowik CWGM & Van der Pluijm G (2007), Bone morphogenetic protein 7 in the development and treatment of bone Metastases from breast cancer, Cancer Research 67(18).
- Weissglas M, Lowik C, Schamhart D, Theuns H, Kurth KH & Papapoulos S (2007), Bone resorption and renal calcium reabsorption in renal cell carcinoma-bearing mice: the effects of bisphosphonate, BJU International 99(6).
- Kaijzel EL, van der Pluijm G & Lowik CWGM (2007), Whole-body optical Imaging in animal models to assess cancer development and progression, Clinical Cancer Research 13(12).
- Chan A, van Bezooijen RL & Lowik CWGM (2007), A new paradigm in the treatment of osteoporosis: Wnt pathway proteins and their antagonists, Current Opinion in Investigational Drugs 8(4).
- Hoogendam J, Farih-Sips H, Wynaendts LC, Lowik CWGM, Wit JM & Karperien M (2007), Novel mutations in the parathyroid hormone (PTH)/PTH-related peptide receptor type 1 causing blomstrand osteochondrodysplasia types I and II, Journal of Clinical Endocrinology and Metabolism 92(3).
- Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao QH, Pukac L, Lowik CWGM & ten Dijke P (2007), BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis, Journal of Cell Science 120(6).
- Bezooijen, R.L. van; DeRuiter, M.C.; Vilain, N.; Monteiro, R.M.; Visser, A.; Wee-Pals, L. van der; Munsteren, C.J. van; Hogendoorn, P.C.W.; Aguet, M.; Mummery, C.L.; Papapoulos, S.E.; Dijke, P. ten & Lowik, C.W.G.M. (2007), SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development, Developmental Dynamics 236(2).
- van Wijngaarden J, van Beek E, van Rossum G, van der Bent C, Hoekman K, van der Pluijm G, van der Pol MA, Broxterman HJ, van Hinsbergh VWM & Lowik CWGM (2007), Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-kappa B-mediated increase of intracellular doxorubicin accumulation, European Journal of Cancer 43(2).
- Schwaninger R, Rentsch CA, Wetterwald A, van der Horst G, van Bezooijen RL, van der Pluijm G, Lowik CWGM, Ackermann K, Pyerin W, Hamdy FC, Thalmann GN & Cecchini MG (2007), Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases, American Journal of Pathology 170(1).
- van Bezooijen RL, Svensson JP, Eefting D, Visser A, van der Horst G, Karperien M, Quax PH, Vrieling H, Papapoulos SE, ten Dijke P & Lowik CW (2007), Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation, Journal of Bone and Mineral Research 22(1).
- Hoogendam J, Farih-Sips H, van Beek E, Lowik CWGM, Wit JM & Karperien M (2007), Novel late response genes of PTHrP in chondrocytes, Hormone Research 67(4).
- Hoogendam J, Parlevliet E, Miclea R, Lowik CWGM, Wit JM & Karperien M (2006), Novel early target genes of parathyroid hormone-related peptide in chondrocytes, Endocrinology 147(6).
- van der Horst G, Farih-Sips H, Lowik CWGM & Karperien M (2006), Full length or fragments in hormone studies? Reply, Journal of Bone and Mineral Research 21(5).
- de Boer J, van Blitterswijk C & Lowik C (2006), Bioluminescent imaging: Emerging technology for non-invasive imaging of bone tissue engineering, Biomaterials 27(9).
- Krom YD, Fallaux FJ, Que I, Lowik C & van Dijk KW (2006), Efficient in vivo knock-down of estrogen receptor alpha: application of recombinant adenovirus vectors for delivery of short hairpin RNA, BMC Biotechnology 6.
- Verhaagh S, de Jong E, Goudsmit J, Lecollinet S, Gillissen G, de Vries M, van Leuven K, Que I, Ouwehand K, Mintardjo R, Weverling GJ, Radosevic K, Richardson J, Eloit M, Lowik C, Quax P & Havenga M (2006), Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors, Journal of General Virology 87.
- van Beek E, Lowik C, Karperien M & Papapoulos S (2006), Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: The role of the retinoic acid receptor, BONE 38(2).
- Deckers M, van Dinther M, Buijs J, Que N, Lowik C, van der Pluijm G & ten Dijke P (2006), The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells, Cancer Research 66(4).
- Steenvoorden MMC, Tolboom TCA, van der Pluijm G, Lowik C, Visser CPJ, DeGroot J, Gittenberger-DeGroot AC, DeRuiter MC, Wisse BJ, Huizinga TWJ & Toes REM (2006), Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics, Arthritis Research and Therapy 8(6).
- Gardner JC, van Bezooijen RL, Mervis B, Hamdy NAT, Lowik CWGM, Hamersma H, Beighton P & Papapoulos SE (2005), Bone mineral density in sclerosteosis; Affected individuals and gene carriers, Journal of Clinical Endocrinology and Metabolism 90(12).
- van der Horst G, Farih-Sips H, Lowik CWGM & Karperien M (2005), Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 cells, Journal of Bone and Mineral Research 20(12).
- van der Horst G, van der Wert SM, Farih-Sips H, van Bezooijen RL, Lowik CWGM & Karperien M (2005), Downregulation of Wnt signaling by increased expression of Dickkopf-1 and-2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells, Journal of Bone and Mineral Research 20(10).
- van der Pluijm G, Que I, Sijmons B, Buijs JT, Lowik CWGM, Wetterwald A, Thalmann GN, Papapoulos SE & Cecchini MG (2005), Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo, Cancer Research 65(17).
- Poole KES, van Bezooijen RL, Loveridge N, Hamersma H, Papapoulos SE, Lowik CW & Reeve J (2005), Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation, FASEB Journal 19(10).
- Franke-Fayard B, Janse CJ, Cunha-Rodrigues M, Ramesar J, Buscher P, Que I, Lowik C, Voshol PJ, den Boer MAM, van Duinen SG, Febbraio M, Mota MM & Waters AP (2005), Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration, Proceedings of the National Academy of Sciences 102(32).
- Dang ZC & Lowik C (2005), Dose-dependent effects of phytoestrogens on bone, Trends in Endocrinology and Metabolism 16(5).
- Bezooijen RL, ten Dijke P, Papapoulos SE & Lowik CWGM (2005), SOST/sclerostin, an osteocyte-derived negative regulator of bone formation, Cytokine and Growth Factor Reviews 16(3).
- Gaetzner S, Deckers MML, Stahl S, Lowik C, Olsen BR & Felbor U (2005), Endostatin's heparan sulfate-binding site is essential for inhibition of angiogenesis and enhances in situ binding to capillary-like structures in bone explants, Matrix Biology 23(8).
- Dang ZC & Lowik CWGM (2005), Removal of serum factors by charcoal treatment promotes adipogenesis via a MAPK-dependent pathway, Molecular and Cellular Biochemistry 268(1-2).
- Horst G. van der, Werf S.M. van der, Sips H.C.M., Bezooijen R.L. van, Löwik C.W.G.M. & Karperien M. (2005), Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late stage obsteoblast differentiation in KS483 cells, Journal of Bone and Mineral Research 20: 1867-1877.
- Gaetzner S., Deckers M.M.L., Stahl S., Löwik C.W.G.M., Olsen B.R. & Felbor U. (2005), Endostatin's heparan sulfate-binding site is essential for inhibition of angiogenesis and enhances in situ binding to capillary-like structures in bone explants, Matrix Biology 23(8): 557-561.
- Horst G. van der, Sips H.C.M., Karperien M. & Löwik C.W.G.M. (2005), Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 cells, Journal of Bone and Mineral Research 20(12): 2233-2244.
- van Wijngaarden J, de Rooij K, van Beek E, Bernsen H, Que I, van Hinsbergh VWM & Lowik C (2004), Identification of differentially expressed genes in a renal cell carcinoma tumor model after endostatin-treatment, Laboratory Investigation 84(11).
- Dang ZC & Lowik CWGM (2004), Differential effects of PD98059 and U0126 on osteogenesis and adipogenesis, Journal of Cellular Biochemistry 92(3).
- Dang ZC & Lowik CWGM (2004), The balance between concurrent activation of ERs and PPARs determines daidzein-induced osteogenesis and adipogenesis, Journal of Bone and Mineral Research 19(5).
- van der Eerden BCJ, Lowik CWGM, Wit JM & Karperien M (2004), Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation.
- Buijs, J.T.; Cleton, A.M.; Smit, V.T.H.B.M.; Lowik, C.W.G.M.; Papapoulos, S.E. & Pluijm, G. van der (2004), Prognostic significance of periodic acid-Schiff-positive patterns in primary breast cancer and its lymph node metastases, Breast Cancer Research and Treatment 84(2).
- van Bezooijen RL, Roelen BAJ, Visser A, van der Wee-Pals L, de Wilt E, Karperien M, Hamersma H, Papapoulos SE, ten Dijke P & Lowik CWGM (2004), Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist, Journal of Experimental Medicine 199(6).
- van der Horst G, Farih-Sips H, Lowik CWGM & Karperien M (2003), Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells, BONE 33(6).
- van Beek ER, Cohen LH, Leroy IM, Ebetino FH, Lowik CWGM & Papapoulos SE (2003), Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates, BONE 33(5).
- van der Pluijm G, Deckers M, Sijmons B, de Groot H, Bird J, Wills R, Papapoulos S, Baxter A & Lowik C (2003), In vitro and in vivo endochondral bone formation models allow identification of anti-angiogenic compounds, American Journal of Pathology 163(1).
- Ciana P, Raviscioni M, Mussi P, Vegeto E, Que I, Parker MG, Lowik C & Maggi A (2003), In vivo imaging of transcriptionally active estrogen receptors, Nature Medicine 9(1).
- Dang ZC, Audinot V, Papapoulos SE, Boutin JA & Lowik CWGM (2003), Peroxisome proliferator-activated receptor gamma (PPAR gamma) as a molecular target for the soy phytoestrogen genistein, Journal of Biological Chemistry 278(2).
- Van Der Horst G, Van Bezooijen RL, Deckers MML, Hoogendam J, Visser A, Lowik CWGM & Karperien M (2002), Differenitiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation, BONE 31(6).
- van der Eerden BCJ, Emons J, Ahmed S, van Essen HW, Lowik CWGM, Wit JM & Karperien M (2002), Evidence for genomic and nongenomic actions of estrogen in growth plate regulation in female and male rats at the onset of sexual maturation, Journal of Endocrinology 175(2).
- van Bezooijen RL, van der Wee-Pals L, Papapoulos SE & Lowik CWGM (2002), Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro, Annals of the Rheumatic Diseases 61(10).
- van der Eerden BCJ, van de Ven J, Lowik CWGM, Wit JM & Karperien M (2002), Sex steroid metabolism in the tibial growth plate of the rat, Endocrinology 143(10).
- Lardenoye JHP, de Vries MR, Lowik CWGM, Xu Q, Dhore CR, Cleutjens JPM, van Hinsbergh VWM, van Bockel JH & Quax PHA (2002), Accelerated atherosclerosis and calcification in vein grafts - A study in APOE*3 Leiden transgenic mice, Circulation Research 91(7).
- Noort WA, Kruisselbrink AB, in't Anker PS, Kruger M, van Bezooijen RL, de Paus RA, Heemskerk MHM, Lowik CWGM, Falkenburg JHF, Willemze R & Fibbe WE (2002), Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice, Experimental Hematology 30(8).
- Deckers MML, Van Beek ER, Van Der Pluijm G, Wetterwald A, Van Der Wee-Pals L, Cecchini MG, Papapoulos SE & Lowik CWGM (2002), Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice, Journal of Bone and Mineral Research 17(6).
- Van Der Eerden BCJ, Van Til NP, Brinkmann AO, Lowik CWGM, Wit JM & Karperien M (2002), Gender differences in expression of androgen receptor in tibial growth plate and metaphyseal bone of the rat, BONE 30(6).
- Deckers MML, van Bezooijen RL, van der Horst G, Hoogendam J, van der Bent C, Papapoulos SE & Lowik CWGM (2002), Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A, Endocrinology 143(4).
- Leenders W, Lubsen N, van Altena M, Clauss M, Deckers M, Lowik C, Breier G, Ruiter D & de Waal R (2002), Design of a variant of vascular endothelial growth factor-A (VEGF-A) antagonizing KDR/Flk-1 and Flt-1, Laboratory Investigation 82(4).
- Dang ZC, Van Bezooijen RL, Karperien M, Papapoulos SE & Lowik CWGM (2002), Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis, Journal of Bone and Mineral Research 17(3).
- Van Der Eerden BCJ, Gevers EF, Lowik CWGM, Karperien M & Wit JM (2002), Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat, BONE 30(3).
- Wetterwald, A.; Pluijm, G. van der; Que, I.; Sijmons, B.; Buijs, J.; Karperien, M.; Lowik, C.W.G.M.; Gautschi, E.; Thalmann, G.N. & Cecchini, M.G. (2002), Optical Imaging of cancer metastasis to bone marrow - A mouse model of minimal residual disease, American Journal of Pathology 160(3).
- Van Beek ER, Lowik CWGM & Papapoulos SE (2002), Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: The role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors, BONE 30(1).
- van der Pluijm G, Sijmons B, Vloedgraven H, van der Bent C, Drijfhout JW, Verheijen J, Quax P, Karperien M, Papapoulos S & Lowik C (2001), Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivo, American Journal of Pathology 159(3).
- Van der Pluijm G, Sijmons B, Vloedgraven H, Deckers M, Papapoulos S & Lowik C (2001), Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: Elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastases, Journal of Bone and Mineral Research 16(6).
- van Bezooijen RL, Papapoulos SE & Lowik CWGM (2001), Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: Is there dependency on nuclear factor-kappa B and receptor activator of nuclear factor kappa B (RANK)/RANK ligand signaling?, BONE 28(4).
- Deckers MML, Smits P, Karperien M, Ni J, Tylzanowski P, Feng P, Parmelee D, Zhang J, Bouffard E, Gentz R, Lowik CWG & Merregaert J (2001), Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro, BONE 28(1).
- Weng L, Falla N, van den Heuvel R, Raymackers J, Karperien M, Van Bezooijen R, Van Vlasselaer P, Lowik C & Merregaert J (2000), The monoclonal antibodies 18d7/91f2 recognize a receptor regulatory protein on mouse bone marrow stromal cells.
- Van Der Eerden BCJ, Karperien M, Gevers EF, Lowik CWGM & Wit JM (2000), Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: Evidence for a locally acting growth restraining feedback loop after birth.
- Deckers MML, Karperien M, van der Bent C, Yamashita T, Papapoulos SE & Lowik CWGM (2000), Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation.
- van der Pluijm G, Lowik C & Papapoulos S (2000), Tumour progression and angiogenesis in bone metastasis from breast cancer: new approaches to an old problem.
- Van Bezooijen RL, Van der Bent C, Papapoulos SE & Lowik CWGM (1999), Oestrogenic compounds modulate cytokine-induced nitric oxide production in mouse osteoblast-like cells.
No relevant ancillary activities