C.L. Mummery
Professor Developmental Biology
- Name
- Prof.dr. C.L. Mummery
- Telephone
- +31 71 526 9300
- c.l.mummery@lumc.nl
Christine Mummery is Chair of the department of Anatomy and Embryology and Professor of Developmental Biology at Leiden University Medical Center. In 2015 she also became guest professor at the Technical University of Twente to develop organ-on-chip models. Dr. Mummery is a member of the Royal Netherlands Academy of Science, is a past board member of the Netherlands Medical Research Council and holds a European Research Council Advanced Grant to study cardiac development and disease in humans based on stem cell models. Prizes include several for the development of animal alternatives. She wrote a lay-guide on stem cells “Stem Cell: Scientific Facts and Fiction” (Elsevier 2014) and is Editor-in-Chief of Stem Cell Reports, the journal of the International Society of Stem Cell Research. She is also on the editorial boards of Cell Stem Cell, Cardiovascular Research and Stem Cells.
Christine Mummery is Chair of the department of Anatomy and Embryology and Professor of Developmental Biology at Leiden University Medical Center. In 2015 she also became guest professor at the Technical University of Twente to develop organ-on-chip models. Dr. Mummery is a member of the Royal Netherlands Academy of Science, is a past board member of the Netherlands Medical Research Council and holds a European Research Council Advanced Grant to study cardiac development and disease in humans based on stem cell models. Prizes include several for the development of animal alternatives. She wrote a lay-guide on stem cells “Stem Cell: Scientific Facts and Fiction” (Elsevier 2014) and is Editor-in-Chief of Stem Cell Reports, the journal of the International Society of Stem Cell Research. She is also on the editorial boards of Cell Stem Cell, Cardiovascular Research and Stem Cells.
Developmental Biology
Research focus concerns cardiovascular development and disease models based on human pluripotent stem cells (hPSC). Immediate interests are on developing biophysical techniques for characterization and functional analysis of cardiovascular cells from hPSC with the ultimate aim of understanding underlying disease mechanisms and drugs for treatment through bioassays. The interest derives from a long-standing fascination on how differentiation choices are made in development and the roles played by growth factors. With the development of human iPS cells by reprogramming somatic cells from patients, enthusiasm for potential clinical applications has grown, particularly in using these cells to identify personalized drug targets and sensitivities and ways correct disease phenotypes. Aside from cardiomyocytes, endothelial cells and vascular smooth muscle cells take a central role in the research, again in a clinical setting where we study a hemorrhaging disease (HHT) caused by mutations in TGFß receptors. We revealed several important mechanism underlying the disease and investigate several candidate drugs now being prescribed to patients. Through collaboration with clinicians in Leiden and Utrecht and engineers in UTwente, we are currently implementing methods for creating synthetic 2-D and 3-D normal and (genetically) diseased vascular and myocardial tissue. These study areas form part of the NWA on personalized medicine, early diagnosis and regenerative medicine.
Current research grants (selection)
- EU FP7 2013-2017 Plurimes. Mesodermal tissue repair using pluripotent stem cells (450k€).
- CVON (Cardiovascular Onderzoek Nederland) NHS. HUSTCARE 2013-2018. Cardiac repair. Co-PI (350k€).
- European Research Council Advanced Grant 2013-2018. Human pluripotent stem cells: the new heart patient. Personal grant/PI (2.5 M€)
- Muller Foundation (2014-2019). hiPSC models for vascular disease. PI (750k€).
- ERARE-CVD: CPVT heart disease models co-PI (350k€).
- ZonMW MKMD (2017-2020) hIPSC as models for cardiac disease. PI (350k€).
- Interreg: Biomat microfluidic chips (2018-2020). PI. (450k€).
- TK-LSH (2018-2020):hiPSC model of arrhythmia. PI (90k€).
- Ministry of Education, Culture and Science NWO Gravity Grant 2017 (2017-2027) Netherlands Organ on Chip Initiative. PI (18.8 mlj €)
Academic career
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Graduation: 1978
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Oration: 2009 ‘Tweede lustrum van humane embryonale stamcellen: van belofte naar feit. Stamcellen worden volwassen’
- 2015: Professor of Vascular Modelling (0.2fte) Technical University of Twente
- 2008: Professor of Developmental Biology, Chair Dept. Anatomy and Embryology, Leiden University Medical Centre (LUMC).
- 2002-2008: Professor of Developmental Biology, Faculty of Medicine, University of Utrecht.
- 2007 - Radcliffe Fellow/visiting professor, Harvard Stem Cell Institute, Cambridge, USA. Engineering cardiac grafts.
- 1993-2008: Senior staff scientist (Tenured), group leader, Hubrecht Institute (KNAW), Utrecht: TGFβ and BMP signalling in mouse development; cardiomyogenesis and vasculogenesis in mouse and human (embryonic) stem cells.
- 1985-1993: Tenured staff scientist, Hubrecht Institute (KNAW), Utrecht. Developmental biology, Differentiation and stem cells
- 1981-1984: Postdoctoral fellowship (fixed term) Hubrecht Laboratory from Shell International Research. “Neuroblastoma and embryonal carcinoma cells as screens for teratogens.
- 1978-1980: Postdoctoral fellowship (fixed term) from the Royal Society, UK. “Ion transport, differentiation and the cell cycle in neuroblastoma cells”
- 1974-1978: PhD in Biophysics, University of London, U.K. Ultrasound in wound healing.
- 1971-1974: BSc. (Honours) in Physics, Electronics, Mathematics, University of Nottingham, U.K.
Prizes and honourable appointments
International prizes/Awards/Academy memberships
- Radcliffe Fellowship, Harvard University (2007)
- Royal Society Fellowship, UK (1978, 1979)
- Member of the Royal Netherlands Academy of Arts and Sciences (KNAW) (elected 2010)
- Hugo van de Poelgeest Prize 2014 for Animal Alternatives
- Hans Bloemendaal Medal 2014 for innovative interdisciplinary research
National activities
- Member of the Royal Netherlands Academy of Arts and Sciences (KNAW) (2010- )
- Member of the governing board of the Netherlands Academy of Arts and Sciences (2011- 2015)
- Member of the governing board of ZonMW (Netherlands Medical Research Council) (2008-2017)
- Member of the Netherlands Central Committee for Research on Humans (CCMO) (2005-2014).
- Member of the National Health Advisory Committee (Gezondheids Raad) on Trend Analysis Biotechnology (2009- )
- Chair of the National Science Council (NWO ) “Zenith” and “Horizon” grant evaluation committees.
- Member of the ter Meulen Fonds (KNAW) selection committee.
- Selection committee for the Netherlands Research Council for large scale facilities (2011-2012)
- Chair of the selection committee for the Heineken Prize for Medicine 2012 and 2014
- Public and patient advocate lectures/science cafes on the risks of stem cell tourism: rotary clubs, Diabetes Fund, Heart Foundation, Young Onset Parkinson group, Huntington Disease group.
International activities
- Member of the board of the International Society for Stem Cell Research (2008-2015)
- President of the International Society of Differentiation (2010-2012).
- Journals: Editor in chief: Stem Cell Reports; former Deputy editor in chief: Stem Cell Research; Editorial Board of Cell Stem Cells, Stem Cells (Lead reviewer), Current Stem Cell Res. and Therapy, Cardiovascular Research, Molecular Therapy and Differentiation; Associate Editor of the International Journal of Developmental Biology.
- Member of the Scientific Advisory Boards of the New York Stem Cell Foundation, EU ESTOOLS (Chair); the International Society for Hereditary Hemorrhagic Telangiectasia.(HHT), CellCure (biotech company developing stem cell therapy for macular degeneration), EU FP7 programme on hematopoiesis; EU IMI StemBANCC,
- Member of the Wellcome Trust Committee, UK (2002-2006) “Molecules, Genes, Cells” and ad hoc specialist committee member (2012).
- Netherlands scientific representative of the International Stem Cell Initiative (ISCI) (2007- )
- Member of the NWO Roadmap selection committee 2012, 2014
- Member of the ERC Starters grant selection committee (2012- )
- Programme committee/organizer of the following (selected) conferences: ISSCR 2013, 2015, 2017; DSSCR 2011- date; ISD 2012; De Snoo 2015; Keystone 2016, 2018.
Professor Developmental Biology
- Faculteit Geneeskunde
- Divisie 4
- Anatomie en Embryologie
- Karina O. Brandao, Lettine van den Brink, Duncan C. Miller, Catarina Grandela, Berend J. van Meer, Mervyn P.H. Mol, Tessa de Korte, Leon G.J. Tertoolen, Christine L. Mummery, Luca Sala, Arie O. Verkerk & and Richard P. Davis (2020), Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias, Stem Cell Reports.
- Schwach, V.; Fernandes, M.G.; Maas, S.; Gerhardt, S.; Tsonaka, R.; Weerd, L. van der; Passier, R.; Mummery, C.L.; Birket, M.J. & Salvatori, D.C.F. (2020), Expandable human cardiovascular progenitors from stem cells for regenerating mouse heart after myocardial infarction, Cardiovascular Research 116(3): 545-553.
- Lettine van den Brink, Karina O. Brandão, Loukia Yiangou, Mervyn P.H. Mol, Catarina Grandela, Christine L. Mummery, Arie O. Verkerk & Richard P. Davis (2020), Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties, Stem Cell Research.
- Brink, L. van den; Grandela, C.; Mummery, C.L. & Davis, R.P. (2019), Concise review: Inherited cardiac diseases, pluripotent stem cells, and genome editing combined-the past, present, and future, STEM CELLS.
- Lettine van den Brink | Catarina Grandela | Christine L. Mummery | Richard P. Davis (2020), Inherited cardiac diseases, pluripotent stem cells and genome editing combined – the past, present and future, STEM CELLS.
- Bouma, M.J.; Freund, C.; IJzerman, A.P.; Boomsma, D.I.; Mummery, C.L. & Raymond, K. (2019), Lymphoblast-derived hiPS cell lines generated from four individuals of a family of genetically unrelated parents and their female monozygotic twins, Stem Cell Research 41.
- Tiemeier, G.L.; Wang, G.Q.; Dumas, S.J.; Sol, W.M.P.J.; Avramut, M.C.; Karakach, T.; Orlova, V.V.; Berg, C.W. van den; Mummery, C.L.; Carmeliet, P.; Berg, B.M. van den & Rabelink, T.J. (2019), Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation, Stem Cell Reports 13(5): 803-816.
- Meer, B.J. van; Krotenberg, A.; Sala, L.; Davis, R.P.; Eschenhagen, T.; Denning, C.; Tertoolen, L.G.J. & Mummery, C.L. (2019), Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes, Nature Communications 10.
- Cao, X.; Yakala, G.K.; Hil, F.E. van den; Cochrane, A.; Mummery, C.L. & Orlova, V.V. (2019), Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives, Stem Cell Reports 12.
- Cao, X.; Yakala, G.K.; Hil, F.E. van den; Cochrane, A.; Mummery, C.L. & Orlova, V.V. (2019), Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives, Stem Cell Reports 12(6): 1282-1297.
- Mummery, C.L. (2018), Perspectives on the Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Biomedical Research, Stem Cell Reports 11(6): 1306-1311.
- Salvatori, D.C.F.; Dorssers, L.C.J.; Gillis, A.J.M.; Perretta, G.; Agthoven, T. van; Fernandes, M.G.; Stoop, H.; Prins, J.B.; Oosterhuis, J.W.; Mummery, C. & Looijenga, L.H.J. (2018), The MicroRNA-371 Family as Plasma Biomarkers for Monitoring Undifferentiated and Potentially Malignant Human Pluripotent Stem Cells in Teratoma Assays, Stem Cell Reports 11(6): 1493-1505.
- Thalgott, J.H.; Dos-Santos-Luis, D.; Hosman, A.E.; Martin, S.; Lamande, N.; Bracquart, D.; Srun, S.; Galaris, G.; Boer, H.C. de; Tual-Chalot, S.; Kroon, S.; Arthur, H.M.; Cao, Y.H.; Snijder, R.J.; Disch, F.; Mager, J.J.; Rabelink, T.J.; Mummery, C.L.; Raymond, K. & Lebrin, F. (2018), Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2, Circulation 138(23): 2698-2712.
- Allison, T.F.; Andrews, P.W.; Avior, Y.; Barbaric, I.; Benvenisty, N.; Bock, C.; Brehm, J.; Brustle, O.; Damjanov, I.; Elefanty, A.; Felkner, D.; Gokhale, P.J.; Halbritter, F.; Healy, L.E.; Hu, T.X.; Knowles, B.B.; Loring, J.F.; Ludwig, T.E.; Mayberry, R.; Micallef, S.; Mohamed, J.S.; Muller, F.J.; Mummery, C.L.; Nakatsuji, N.; Ng, E.S.; Oh, S.K.W.; O'Shea, O.; Pera, M.F.; Reubinoff, B.; Robson, P.; Rossant, J.; Schuldt, B.M.; Solter, D.; Sourris, K.; Stacey, G.; Stanley, E.G.; Suemori, H.; Takahashi, K.; Yamanaka, S. & Int Stem Cell Initiative (2018), Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells, Nature Communications 9.
- Halaidych, O.V.; Freund, C.; Hil, F. van den; Salvatori, D.C.F.; Riminucci, M.; Mummery, C.L. & Orlova, V.V. (2018), Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells, Stem Cell Reports 10(5): 1642-1656.
- Tong, C.Q.; Liu, T.X.; Talens, V.S.; Noteborn, W.E.M.; Sharp, T.H.; Hendrix, M.M.R.M.; Voets, I.K.; Mummery, C.L.; Orlova, V.V. & Kieltyka, R.E. (2018), Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives, Biomacromolecules 19(4): 1091-1099.
- Anderson, D.J.; Kaplan, D.I.; Bell, K.M.; Koutsis, K.; Haynes, J.M.; Mills, R.J.; Phelan, D.G.; Qian, E.L.; Leitoguinho, A.R.; Arasaratnam, D.; Labonne, T.; Ng, E.S.; Davis, R.P.; Casini, S.; Passier, R.; Hudson, J.E.; Porrello, E.R.; Costa, M.W.; Rafii, A.; Curl, C.L.; Delbridge, L.M.; Harvey, R.P.; Oshlack, A.; Cheung, M.M.; Mummery, C.L.; Petrou, S.; Elefanty, A.G.; Stanley, E.G. & Elliott, D.A. (2018), NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network, Nature Communications 9.
- Tertoolen, L.G.J.; Braam, S.R.; Meer, B.J. van; Passier, R. & Mummery, C.L. (2018), Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes, Biochemical and Biophysical Research Communications 497(4): 1135-1141.
- Sala, L.; Meer, B.J. van; Tertoolen, L.G.J.; Bakkers, J.; Bellin, M.; Davis, R.P.; Denning, C.; Dieben, M.A.E.; Eschenhagen, T.; Giacomelli, E.; Grandela, C.; Hansen, A.; Holman, E.R.; Jongbloed, M.R.M.; Kamel, S.M.; Koopman, C.D.; Lachaud, Q.; Mannhardt, I.; Mol, M.P.H.; Mosqueira, D.; Orlova, V.V.; Passier, R.; Ribeiro, M.C.; Saleem, U.; Smith, G.L.; Burton, F.L. & Mummery, C.L. (2018), MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo, Circulation Research 122(3): e5-e16.
- Schwach, V.; Verkerk, A.O.; Mol, M.; Monshouwer-Kloots, J.J.; Devalla, H.D.; Orlova, V.V.; Anastassiadis, K.; Mummery, C.L.; Davis, R.P. & Passier, R. (2017), A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes, Stem Cell Reports 9(6): 1765-1779.
- Guadix, J.A.; Orlova, V.V.; Giacomelli, E.; Bellin, M.; Ribeiro, M.C.; Mummery, C.L.; Perez-Pomares, J.M. & Passier, R. (2017), Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells, Stem Cell Reports 9(6): 1754-1764.
- Harris, K.; Rossman, E.; Xu, X.; Clements, P.; Mannhardt, I.; Hansen, A.; Saleem, U.; Eschenhagen, T.; Hortigon, M.; Rodriguez, V.Z.; Smith, G.; Meer, B. van; Tertoolen, L.; Mummery, C.; Ribeiro, M.; Passier, R.; Korte, T. de; Vlaming, M.; Braam, S.; Vickers, C.; Mosqueira, D.; Firth, K.; Prodanov, L.; George, V. & Denning, C. (2017), InPulse CrackIT Challenge: Development of An In Vitro Platform Using Physiologically Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Screen for Drug-Induced Effects on Cardiac Contractility, Journal of Pharmacological and Toxicological Methods 88: 238-238.
- Eldik, W. van; Adel, B. den; Monshouwer-Kloots, J.; Salvatori, D.; Maas, S.; Made, I. van der; Creemers, E.E.; Frank, D.; Frey, N.; Boontje, N.; Velden, J. van der; Steendijk, P.; Mummery, C.; Passier, R. & Beqqali, A. (2017), Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart, PLoS ONE 12(12).
- Sala, L.; Bellin, M. & Mummery, C.L. (2017), Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?, British Journal of Pharmacology 174(21): 3749-3765.
- Giacomelli, E.; Mummery, C.L. & Bellin, M. (2017), Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes, Cellular and Molecular Life Sciences 74(20): 3711-3739.
- Roost, M.S.; Slieker, R.C.; Bialecka, M.; Iperen, L. van; Fernandes, M.M.G.; He, N.N.; Suchiman, H.E.D.; Szuhai, K.; Carlotti, F.; Koning, E.J.P. de; Mummery, C.L.; Heijmans, B.T. & Lopes, S.M.C.D. (2017), DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells, Nature Communications 8.
- Brandao, K.O.; Tabel, V.A.; Atsma, D.E.; Mummery, C.L. & Davis, R.P. (2017), Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies, Disease Models and Mechanisms 10(9): 1039-1059.
- Sala, L.; Ward-van Oostwaard, D.; Tertoolen, L.G.J.; Mummery, C.L. & Bellin, M. (2017), Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs), Journal of Visualized Experiments.
- Bouma, M.J.; Iterson, M. van; Janssen, B.; Mummery, C.L.; Salvatori, D.C.F. & Freund, C. (2017), Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays, Stem Cell Reports 8(5): 1340-1353.
- Falke, L.L.; Leeuwis, J.W.; Lyons, K.M.; Mummery, C.L.; Nguyen, T.Q. & Goldschmeding, R. (2017), CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy, Journal of Cell Communication and Signaling 11(1): 39-48.
- Giacomelli, E.; Bellin, M.; Sala, L.; Meer, B.J. van; Tertoolen, L.G.J.; Orlova, V.V. & Mummery, C.L. (2017), Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells, Development 144(6): 1008-1017.
- Chen, Z.F.; Xian, W.Y.; Bellin, M.; Dorn, T.; Tian, Q.H.; Goedel, A.; Dreizehnter, L.; Schneider, C.M.; Oostwaard, D.V.; Ng, J.K.M.; Hinkel, R.; Pane, L.S.; Mummery, C.L.; Lipp, P.; Moretti, A.; Laugwitz, K.L. & Sinnecker, D. (2017), Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes, European Heart Journal 38(4): 292-301.
- Meer, B.J. van; Vries, H. de; Firth, K.S.A.; Weerd, J. van; Tertoolen, L.G.J.; Karperien, H.B.J.; Jonkheijm, P.; Denning, C.; IJzerman, A.P. & Mummery, C.L. (2017), Small molecule absorption by PDMS in the context of drug response bioassays, Biochemical and Biophysical Research Communications 482(2): 323-328.
- Haan, G. de; Crom, R. de; Dzierzak, E. & Mummery, C. (2017), Regenerative medicine funding policies in Europe and The Netherlands, npj Regenerative Medicine 2.
- Chen, Z.; Xian, W.; Bellin, M.; Dorn, T.; Tian, Q.; Mummery, C.L.; Lipp, P.; Moretti, A.; Sinnecker, D. & Laugwitz, K.L. (2016), SUBTY PE-SPECIFIC PROMOTER-DRIVEN ACTION POTENTIAL IMAGING FOR PRECISE DISEASE MODELING AND DRUG TESTING IN HIPSC-DERIVED CARDIOMYOCYTES, Cardiology 134: 436-436.
- Devalla, H.D.; Gelinas, R.; Aburawi, E.H.; Beqqali, A.; Goyette, P.; Freund, C.; Chaix, M.A.; Tadros, R.; Jiang, H.; Bechec, A. le; Monshouwer-Kloots, J.J.; Zwetsloot, T.; Kosmidis, G.; Latour, F.; Alikashani, A.; Hoekstra, M.; Schlaepfer, J.; Mummery, C.L.; Stevenson, B.; Kutalik, Z.; Vries, A.A.F. de; Rivard, L.; Wilde, A.A.M.; Talajic, M.; Verkerk, A.O.; Al-Gazali, L.; Rioux, J.D.; Bhuiyan, Z.A. & Passier, R. (2016), TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT, EMBO Molecular Medicine 8(12): 1390-1408.
- Gaio, N.; Silvestri, C.; Meer, B. van; Vollebregt, S.; Mummery, C.L. & Dekker, R. (2016), Fabrication and Characterization of an Upside-Down Carbon Nanotube Microelectrode Array, IEEE Sensors Journal 16(24): 8685-8691.
- Mummery, C.; Birket, M.; Meer, B.; Ribeiro, M.; Passier, R.; Bellin, M.; Orlova, V.; Davis, R.; Freund, C.; Kosmidis, G. & Tertoolen, L. (2016), Challenges of immaturity and proliferation in using hPSC-derived cardiomyocytes as disease models, Human Gene Therapy 27(11): A11-A11.
- Kosmidis, G.; Veerman, C.C.; Casini, S.; Verkerk, A.O.; Pas, S. van de; Bellin, M.; Wilde, A.A.M.; Mummery, C.L. & Bezzina, C.R. (2016), Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Na(v)1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A, Circulation: Arrhythmia and Electrophysiology 9(11).
- Vlaming, M.; Stevenhagen, F.; Korte, T. de; Langenberg, K.; Dunska, M.; Tertoolen, L.; Mummery, C.; Grandela, C. & Braam, S. (2016), Improved functional maturation of human induced pluripotent stem cell (hiPSC) derived ventricular cardiomyocytes in vitro: Multi-electrode array (MEA) based electrophysiological characterization, Journal of Pharmacological and Toxicological Methods 81: 347-348.
- Meer, B. van; Ribeiro, M.; Tertoolen, L.; Birket, M.; Passier, R. & Mummery, C. (2016), Organ-on-Chip: A synthetic mimic for human myocardium, Journal of Pharmacological and Toxicological Methods 81: 388-388.
- Sala, L.; Yu, Z.Y.; Ward-van Oostwaard, D.; Veldhoven, J.P.D. van; Moretti, A.; Laugwitz, K.L.; Mummery, C.L.; IJzerman, A.P. & Bellin, M. (2016), A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells, EMBO Molecular Medicine 8(9): 1065-1081.
- Meer, B.J. van; Tertoolen, L.G.J. & Mummery, C.L. (2016), Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease, STEM CELLS 34(8): 2008-2015.
- Bellin, M. & Mummery, C.L. (2016), Inherited heart disease - what can we expect from the second decade of human iPS cell research?, FEBS Letters 590(15): 2482-2493.
- Schmitz, F.; Kooy-Winkelaar, Y.; Wiekmeijer, A.S.; Brugman, M.H.; Mearin, M.L.; Mulder, C.; Lopes, S.C.D.; Mummery, C.L.; Staal, F.J.T.; Bergen, J. van & Koning, F. (2016), The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease, Gut 65(8): 1269-1278.
- Gaio, N.; Meer, B. van; Solano, W.Q.; Bergers, L.; Stolpe, A. van de; Mummery, C.; Sarro, P.M. & Dekker, R. (2016), Cytostretch, an Organ-on-Chip Platform, Micromachines 7(7).
- Bellin, M. & Mummery, C.L. (2016), The cancer's gone, but did chemotherapy damage your heart?, Nature Reviews Cardiology 13(7): 383-384.
- Crisan, M.; Kartalaei, P.S.; Vink, C.S.; Yamada-Inagawa, T.; Neagu, A.; Karkanpouna, S.; Bollerot, K.; Purini, C.; Ijcken, W. van; Linden, R. van der; Lopes, S.M.C.D.; Monteiro, R.; Mummery, C. & Dzierzak, E. (2016), BIFURCATION INTO HEMATOPOIETIC STEM CELL TYPES IS DEPENDENT UPON THE DEVELOPMENTAL SIGNALING MOLECULES, Haematologica 101: 291-292.
- Kelder, T.P.; Vicente-Steijn, R.; Poelmann, R.E.; Mummery, C.L.; DeRuiter, M.C. & Jongbloed, M.R.M. (2016), The avian embryo to study development of the cardiac conduction system, Differentiation 91(4-5): 90-103.
- Madonna, R.; Laake, L. van; Davidson, S.M.; Engel, F.B.; Hausenloy, D.J.; Lecour, S.; Leor, J.; Perrino, C.; Schulz, R.; Ytrehus, K.; Landmesser, U.; Mummery, C.L.; Janssens, S.; Willerson, J.; Eschenhagen, T.; Ferdinandy, P. & Sluijter, J.P.G. (2016), Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure, European Heart Journal 37(23): 1789-1798D.
- Gkatzis, K.; Thalgott, J.; Dos-Santos-Luis, D.; Martin, S.; Lamande, N.; Carette, M.F.; Disch, F.; Snijder, R.J.; Westermann, C.J.; Mager, J.J.; Oh, S.P.; Miquerol, L.; Arthur, H.M.; Mummery, C.L. & Lebrin, F. (2016), Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations, Arteriosclerosis, Thrombosis, and Vascular Biology 36(4): 707-717.
- Amit, I.; Baker, D.; Barker, R.; Berger, B.; Bertozzi, C.; Bhatia, S.; Biffi, A.; Demichelis, F.; Doudna, J.; Dowdy, S.F.; Endy, D.; Helmstaedter, M.; Junca, H.; June, C.; Kamb, S.; Khvorova, A.; Kim, D.H.; Kim, J.S.; Krishnan, Y.; Lakadamyali, M.; Lappalainen, T.; Lewin, S.; Liao, J.; Loman, N.; Lundberg, E.; Lynd, L.; Martin, C.; Mellman, I.; Miyawaki, A.; Mummery, C.; Nelson, K.; Paz, J.; Peralta-Yahya, P.; Picotti, P.; Polyak, K.; Prather, K.; Qin, J.; Quake, S.; Regev, A.; Rogers, J.A.; Shetty, R.; Sommer, M.; Stevens, M.; Stolovitzky, G.; Takahashi, M.; Tang, F.; Teichmann, S.; Torres-Padilla, M.E.; Tripathi, L.; Vemula, P.; Verdine, G.; Vollmer, F.; Wang, J.; Ying, J.Y.; Zhang, F. & Zhang, T. (2016), Voices of biotech, Nature Biotechnology 34(3): 270-275.
- Crisan, M.; Kartalaei, P.S.; Neagu, A.; Karkanpouna, S.; Yamada-Inagawa, T.; Purini, C.; Vink, C.S.; Linden, R. van der; Ijcken, W. van; Lopes, S.M.C.D.; Monteiro, R.; Mummery, C. & Dzierzak, E. (2016), BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo, Stem Cell Reports 6(3): 383-395.
- Passier, R.; Orlova, V. & Mummery, C. (2016), Complex Tissue and Disease Modeling using hiPSCs, Cell Stem Cell 18(3): 309-321.
- Engert, A.; Balduini, C.; Brand, A.; Coiffier, B.; Cordonnier, C.; Dohner, H.; Wit, T.D. de; Eichinger, S.; Fibbe, W.; Green, T.; Haas, F. de; Iolascon, A.; Jaffredo, T.; Rodeghiero, F.; Salles, G.; Schuringa, J.J.; Andre, M.; Andre-Schmutz, I.; Bacigalupo, A.; Bochud, P.Y.; Boer, M. den; Bonini, C.; Camaschella, C.; Cant, A.; Cappellini, M.D.; Cazzola, M.; Celso, C. lo; Dimopoulos, M.; Douay, L.; Dzierzak, E.; Einsele, H.; Ferreri, A.; Franceschi, L. de; Gaulard, P.; Gottgens, B.; Greinacher, A.; Gresele, P.; Gribben, J.; Haan, G. de; Hansen, J.B.; Hochhaus, A.; Kadir, R.; Kaveri, S.; Kouskoff, V.; Kuhne, T.; Kyrle, P.; Ljungman, P.; Maschmeyer, G.; Mendez-Ferrer, S.; Milsom, M.; Mummery, C.; Ossenkoppele, G.; Pecci, A.; Peyvandi, F.; Philipsen, S.; Reitsma, P.; Ribera, J.M.; Risitano, A.; Rivella, S.; Ruf, W.; Schroeder, T.; Scully, M.; Socie, G.; Staal, F.; Stanworth, S.; Stauder, R.; Stilgenbauer, S.; Tamary, H.; Theilgaard-Monch, K.; Thein, S.L.; Tilly, H.; Trneny, M.; Vainchenker, W.; Vannucchi, A.M.; Viscoli, C.; Vrielink, H.; Zaaijer, H.; Zanella, A.; Zolla, L.; Zwaginga, J.J.; Martinez, P.A.; Akker, E. van den; Allard, S.; Anagnou, N.; Andolfo, I.; Andrau, J.C.; Angelucci, E.; Anstee, D.; Aurer, I.; Avet-Loiseau, H.; Aydinok, Y.; Bakchoul, T.; Balduini, A.; Barcellini, W.; Baruch, D.; Baruchel, A.; Bayry, J.; Bento, C.; Berg, A. van den; Bernardi, R.; Bianchi, P.; Bigas, A.; Biondi, A.; Bohonek, M.; Bonnet, D.; Borchmann, P.; Borregaard, N.; Braekkan, S.; Brink, M. van den; Brodin, E.; Bullinger, L.; Buske, C.; Butzeck, B.; Cammenga, J.; Campo, E.; Carbone, A.; Cervantes, F.; Cesaro, S.; Charbord, P.; Claas, F.; Cohen, H.; Conard, J.; Coppo, P.; Corrons, J.L.V.; Costa, L. da; Davi, F.; Delwel, R.; Dianzani, I.; Domanovic, D.; Donnelly, P.; Drnovsek, T.D.; Dreyling, M.; , M.Q. du; Dufour, C.; Durand, C.; Efremov, D.; Eleftheriou, A.; Elion, J.; Emonts, M.; Engelhardt, M.; Ezine, S.; Falkenburg, F.; Favier, R.; Federico, M.; Fenaux, P.; Fitzgibbon, J.; Flygare, J.; Foa, R.; Forrester, L.; Galacteros, F.; Garagiola, I.; Gardiner, C.; Garraud, O.; Geet, C. van; Geiger, H.; Geissler, J.; Germing, U.; Ghevaert, C.; Girelli, D.; Godeau, B.; Gokbuget, N.; Goldschmidt, H.; Goodeve, A.; Graf, T.; Graziadei, G.; Griesshammer, M.; Gruel, Y.; Guilhot, F.; Gunten, S. von; Gyssens, I.; Halter, J.; Harrison, C.; Harteveld, C.; Hellstrom-Lindberg, E.; Hermine, O.; Higgs, D.; Hillmen, P.; Hirsch, H.; Hoskin, P.; Huls, G.; Inati, A.; Johnson, P.; Kattamis, A.; Kiefel, V.; Kleanthous, M.; Klump, H.; Krause, D.; Hovinga, J.K.; Lacaud, G.; Lacroix-Desmazes, S.; Landman-Parker, J.; LeGouill, S.; Lenz, G.; Lilienfeld-Toal, M. von; Lindern, M. von; Lopez-Guillermo, A.; Lopriore, E.; Lozano, M.; MacIntyre, E.; Makris, M.; Makris, M.; Martens, J.; Mathas, S.; Matzdorff, A.; Medvinsky, A.; Menendez, P.; Migliaccio, A.R.; Miharada, K.; Mikulska, M.; Minard, V.; Montalban, C.; Montalembert, M. de; Montserrat, E.; Morange, P.E.; Mountford, J.; Muckenthaler, M.; Muller-Tidow, C.; Mumford, A.; Nadel, B.; Navarro, J.T.; Nemer, W. el; Noizat-Pirenne, F.; O'Mahony, B.; Oldenburg, J.; Olsson, M.; Oostendorp, R.; Palumbo, A.; Passamonti, F.; Patient, R.; Latour, R.P. de; Pflumio, F.; Pierelli, L.; Piga, A.; Pollard, D.; Raaijmakers, M.; Radford, J.; Rambach, R.; Rao, A.K.; Raslova, H.; Rebulla, P.; Rees, D.; Ribrag, V.; Rijneveld, A.; Rinalducci, S.; Robak, T.; Roberts, I.; Rodrigues, C.; Rosendaal, F.; Rosenwald, A.; Rule, S.; Russo, R.; Saglio, G.; Sanchez, M.; Scharf, R.E.; Schlenke, P.; Semple, J.; Sierra, J.; So-Osman, C.; Soria, J.M.; Stamatopoulos, K.; Stegmayr, B.; Stunnenberg, H.; Swinkels, D.; Barata, J.P.T.; Taghon, T.; Taher, A.; Terpos, E.; Thachil, J.; Tissot, J.D.; Touw, I.; Toye, A.; Trappe, R.; Traverse-Glehen, A.; Unal, S.; Vaulont, S.; Viprakasit, V.; Vitolo, U.; Wijk, R. van; Wojtowicz, A.; Zeerleder, S.; Zieger, B. & EHA Roadmap European Hematology Re (2016), The European Hematology Association Roadmap for European Hematology Research: a consensus document, Haematologica 101(2): 115-208.
- Hartogh S.C. den, Wolstencroft K.J., Mummery C.L. & Passier R. (2016), A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors, SCIENTIFIC REPORTS 6: 19386.
- Hartogh, S.C. den; Wolstencroft, K.; Mummery, C.L. & Passier, R. (2016), A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors, Scientific Reports 6.
- Fernandes, M.G.; Dries, R.; Roost, M.S.; Semrau, S.; Bernardo, A.D.; Davis, R.P.; Ramakrishnan, R.; Szuhai, K.; Maas, E.; Umans, L.; Escalona, V.A.; Salvatori, D.; Deforce, D.; Criekinge, W. van; Huylebroeck, D.; Mummery, C.; Zwijsen, A. & Lopes, S.M.C.D. (2016), BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells, Stem Cell Reports 6(1): 85-94.
- Hosman, A.E.; Westermann, C.J.J.; Snijder, R.; Disch, F.; Mummery, C.L. & Mager, J.J. (2015), Follow-up of Thalidomide treatment in patients with Hereditary Haemorrhagic Telangiectasia, Rhinology 53(4): 340-344.
- Andrews, P.W.; Baker, D.; Benvinisty, N.; Miranda, B.; Bruce, K.; Brustle, O.; Choi, M.; Choi, Y.M.; Crook, J.M.; Sousa, P.A. de; Dvorak, P.; Freund, C.; Firpo, M.; Furue, M.K.; Gokhale, P.; Ha, H.Y.; Han, E.; Haupt, S.; Healy, L.; Hei, D.J.; Hovatta, O.; Hunt, C.; Hwang, S.M.; Inamdar, M.S.; Isasi, R.M.; Jaconi, M.; Jekerle, V.; Kamthorn, P.; Kibbey, M.C.; Knezevic, I.; Knowles, B.B.; Koo, S.K.; Laabi, Y.; Leopoldo, L.; Liu, P.; Lomax, G.P.; Loring, J.F.; Ludwig, T.E.; Montgomery, K.; Mummery, C.; Nagy, A.; Nakamura, Y.; Nakatsuji, N.; Oh, S.; Oh, S.K.; Otonkoski, T.; Pera, M.; Peschanski, M.; Pranke, P.; Rajala, K.M.; Rao, M.; Ruttachuk, R.; Reubinoff, B.; Ricco, L.; Rooke, H.; Sipp, D.; Stacey, G.N.; Suemori, H.; Takahashi, T.A.; Takada, K.; Talib, S.; Tannenbaum, S.; Yuan, B.Z.; Zeng, F. & Zhou, Q. (2015), Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI), Regenerative Medicine 10(2): 1-44.
- Gaio N., van Meer B., Silvestri C., Pakazad S., Vollebregt S., Mummery C. L. & Dekker R. (2015), Upside-down Carbon Nanotube (CNT) Micro-electrode Array (MEA), Proceedings of IEEE Sensors: 691-694.
- Cai, J.; Orlova, V.V.; Cai, X.J.; Eekhoff, E.M.W.; Zhang, K.Q.; Pei, D.Q.; Pan, G.J.; Mummery, C.L. & Dijke, P. ten (2015), Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva, Stem Cell Reports 5(6): 963-970.
- Kosmidis, G.; Bellin, M.; Ribeiro, M.C.; Meer, B. van; Ward-van Oostwaard, D.; Passier, R.; Tertoolen, L.G.J.; Mummery, C.L. & Casini, S. (2015), Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure, Biochemical and Biophysical Research Communications 467(4): 998-1005.
- Mummery, C.L.; Gkatzis, K.; Freund, C.; Lebrin, F.; Dijke, P. ten; Passier, R.; Westermann, C.J.J.; Snijder, R.; Mager, H.J. & Orlova, V.V. (2015), Endoglin haploinsufficency in endothelial cells from Rendu-Osler-Weber patient derived induced pluripotent stem cells leads to upregulation of MTUS1 gene expression, Angiogenesis 18(4): 574-574.
- Hosman, A.E.; Westermann, C.J.J.; Snijder, R.; Disch, F.; Mummery, C.L. & Mager, J.J. (2015), Followup of thalidomide treatment in patients with hereditary haemorrhagic telangiectasia, Angiogenesis 18(4): 560-561.
- Orlova, V.; Freund, C.; Hil, L. van den; Reurer, S.P.; Hawinkels, L.; Duffhues, G.S.; Disch, F.; Hans, J.M.; Snijder, R.; Westermann, K.; Dijke, P. ten & Mummery, C. (2015), Modeling hereditary haemorrhagic telangiectasia (HHT) with patient specific induced pluripotent stem cells (IPSCS), Angiogenesis 18(4): 532-532.
- Pera, M.F.; Wert, G. de; Dondorp, W.; Lovell-Badge, R.; Mummery, C.L.; Munsie, M. & Tam, P.P. (2015), What if stem cells turn into embryos in a dish?, Nature Methods 12(10): 917-919.
- Birket, M.J.; Ribeiro, M.C.; Verkerk, A.O.; Ward, D.; Leitoguinho, A.R.; Hartogh, S.C. den; Orlova, V.V.; Devalla, H.D.; Schwach, V.; Bellin, M.; Passier, R. & Mummery, C.L. (2015), Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells, Nature Biotechnology 33(9): 970-U219.
- Berg, C.W. van den; Okawa, S.; Lopes, S.M.C.D.; Iperen, L. van; Passier, R.; Braam, S.R.; Tertoolen, L.G.; Sol, A. del; Davis, R.P. & Mummery, C.L. (2015), Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells, Development 142(18): 3231-U263.
- Crisan, M.; Kartalaei, P.S.; Vink, C.; Yamada-Inagawa, T.; Bollerot, K.; IJcken, W. van; Linden, R. van der; Lopes, S.M.C.D.; Monteiro, R.; Mummery, C. & Dzierzak, E. (2015), BMP signalling differentially regulates distinct haematopoietic stem cell types, Nature Communications 6.
- Roost, M.S.; Iperen, L. van; Ariyurek, Y.; Buermans, H.P.; Arindrarto, W.; Devalla, H.D.; Passier, R.; Mummery, C.L.; Carlotti, F.; Koning, E.J.P. de; Zwet, E.W. van; Goeman, J.J. & Lopes, S.M.C.D. (2015), KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas, Stem Cell Reports 4(6): 1112-1124.
- Ribeiro, M.C.; Tertoolen, L.G.; Guadix, J.A.; Bellin, M.; Kosmidis, G.; D'Aniello, C.; Monshouwer-Kloots, J.; Goumans, M.J.; Wang, Y.L.; Feinberg, A.W.; Mummery, C.L. & Passier, R. (2015), Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro - Correlation between contraction force and electrophysiology, Biomaterials 51: 138-150.
- Orlova, V.V. & Mummery, C.L. (2015), What Endothelial Cells from Patient iPSCs Can Tell Us about Aortic Valve Disease, Cell Stem Cell 16(5): 455-457.
- Devalla, H.D.; Schwach, V.; Ford, J.W.; Milnes, J.T.; El-Haou, S.; Jackson, C.; Gkatzis, K.; Elliott, D.A.; Lopes, S.M.C.D.; Mummery, C.L.; Verkerk, A.O. & Passier, R. (2015), Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology, EMBO Molecular Medicine 7(4): 394-410.
- Greber, B.; Verkerk, A.O.; Seebohm, G.; Mummery, C.L. & Bellin, M. (2015), Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations, Proceedings of the National Academy of Sciences 112(16): E1969-E1969.
- Veerman, C.C.; Kosmidis, G.; Mummery, C.L.; Casini, S.; Verkerk, A.O. & Bellin, M. (2015), Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?
- Birket, M.J. & Mummery, C.L. (2015), Pluripotent stem cell derived cardiovascular progenitors - A developmental perspective, Developmental Biology 400(2): 169-179.
- Eschenhagen, T.; Mummery, C. & Knollmann, B.C. (2015), Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes, Cardiovascular Research 105(4): 424-438.
- Hartogh, S.C. den; Schreurs, C.; Monshouwer-Kloots, J.J.; Davis, R.P.; Elliott, D.A.; Mummery, C.L. & Passier, R. (2015), Dual Reporter MESP1(mCherry/w)-NKX2-5(eGFP/w) hESCs Enable Studying Early Human Cardiac Differentiation, STEM CELLS 33(1): 56-67.
- Gomes Fernandes M., Dries R., Roost M.S., Semrau S., de Melo Bernardo A., Davis Richard P., Ramakrishnan R., Szuhai K., Maas E., Umans L., Abon Escalona V., Salvatori D., Deforce D., Van Criekinge W., Huylebroeck D., Mummery C., Zwijsen A. & de Sousa Lopes S.M. (2015), BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells, Stem Cell Reports 6(1): 85-94.
- Bernardo, A.D.; Thorsteinsdottir, S. & Mummery, C.L. (2015), Advantages of the avian model for human ovarian cancer, Molecular and Clinical Oncology.
- Birket, M.J.; Ribeiro, M.C.; Kosmidis, G.; Ward, D.; Leitoguinho, A.R.; Pol, V. van de; Dambrot, C.; Devalla, H.D.; Davis, R.P.; Mastroberardino, P.G.; Atsma, D.E.; Passier, R. & Mummery, C.L. (2015), Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function, Cell Reports.
- Schmitz, F.; Kooy-Winkelaar, Y.; Wiekmeijer, A.S.; Brugman, M.H.; Mearin, M.L.; Mulder, C.; Lopes, S.C.D.; Mummery, C.L.; Staal, F.J.T.; Bergen, J. van & Koning, F. (2015), The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease.
- Zhang, M.; D'Aniello, C.; Verkerk, A.O.; Wrobel, E.; Frank, S.; Oostwaard, D.W.; Piccini, I.; Freund, C.; Rao, J.; Seebohm, G.; Atsma, D.E.; Schulze-Bahr, E.; Mummery, C.L.; Greber, B. & Bellin, M. (2014), Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue, Proceedings of the National Academy of Sciences 111(50): E5383-E5392.
- Soares, F.A.C.; Sheldon, M.; Rao, M.; Mummery, C. & Vallier, L. (2014), International Coordination of Large-Scale Human Induced Pluripotent Stem Cell Initiatives: Wellcome Trust and ISSCR Workshops White Paper, Stem Cell Reports 3(6): 931-939.
- Dekkers, O.M.; Mummery, C.L. & Rabelink, T.J. (2014), A Case for Crowd Sourcing in Stem Cell Research, Stem Cells Translational Medicine 3(11): 1259-1261.
- Mummery, C. (2014), Derivatives of Human Pluripotent Stem Cells: the new patient?, Human Gene Therapy 25(11): A16-A16.
- Mikkers, H.M.; Feund, C.; Mummery, C.L. & Hoeben, R.C. (2014), Cell Replacement Therapies: Is It Time to Reprogram?, Human Gene Therapy 25(10): 866-874.
- Dambrot, C.; Buermans, H.P.J.; Varga, E.; Kosmidis, G.; Langenberg, K.; Casini, S.; Elliott, D.A.; Dinnyes, A.; Atsma, D.E.; Mummery, C.L.; Braam, S.R. & Davis, R.P. (2014), Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones, Experimental Cell Research 327(2): 297-306.
- Dambrot, C.; Braam, S.R.; Tertoolen, L.G.J.; Birket, M.; Atsma, D.E. & Mummery, C.L. (2014), Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
- Orlova, V.V.; Freund, C.; Petrus-Reurer, S.; Hil, F.E. van den; Drabsch, Y.; Dijke, P. ten & Mummery, C.L. (2014), Differentiation and functionality of endothelial cells and pericytes from human induced pluripotent stem cells, Angiogenesis 17(3): 760-760.
- Skelton, R.J.P.; Costa, M.; Anderson, D.J.; Bruveris, F.; Finnin, B.W.; Koutsis, K.; Arasaratnam, D.; White, A.J.; Rafii, A.; Ng, E.S.; Elefanty, A.G.; Stanley, E.G.; Pouton, C.W.; Haynes, J.M.; Ardehali, R.; Davis, R.P.; Mummery, C.L. & Elliott, D.A. (2014), SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development, Stem Cell Research 13(1): 172-179.
- Orlova, V.V.; Hil, F.E. van den; Petrus-Reurer, S.; Drabsch, Y.; Dijke, P. ten & Mummery, C.L. (2014), Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells, Nature Protocols 9(6): 1514-1531.
- Mummery, C.L. (2014), Cardiomyocytes from human pluripotent stem cells: the new patient in safety pharmacology, drug discovery and disease, European Journal of Clinical Investigation 44: 5-5.
- Mummery, C.L. (2014), Putting stem cell to work in understanding gender differences, European Journal of Clinical Investigation 44: 4-4.
- Richter, A.; Valdimarsdottir, L.; Hrafnkelsdottir, H.E.; Runarsson, J.F.; Omarsdottir, A.R.; Ward-van Oostwaard, D.; Mummery, C. & Valdimarsdottir, G. (2014), BMP4 Promotes EMT and Mesodermal Commitment in Human Embryonic Stem Cells via SLUG and MSX2, STEM CELLS 32(3): 636-648.
- Novakovic, G.V.; Eschenhagen, T. & Mummery, C. (2014), Myocardial Tissue Engineering: In Vitro Models, Cold Spring Harbor perspectives in medicine 4(3).
- Forrest, A.R.R.; Kawaji, H.; Rehli, M.; Baillie, J.K.; Hoon, M.J.L. de; Haberle, V.; Lassmann, T.; Kulakovskiy, I.V.; Lizio, M.; Itoh, M.; Andersson, R.; Mungall, C.J.; Meehan, T.F.; Schmeier, S.; Bertin, N.; Jorgensen, M.; Dimont, E.; Arner, E.; Schmidl, C.; Schaefer, U.; Medvedeva, Y.A.; Plessy, C.; Vitezic, M.; Severin, J.; Semple, C.A.; Ishizu, Y.; Young, R.S.; Francescatto, M.; Alam, I.; Albanese, D.; Altschuler, G.M.; Arakawa, T.; Archer, J.A.C.; Arner, P.; Babina, M.; Rennie, S.; Balwierz, P.J.; Beckhouse, A.G.; Pradhan-Bhatt, S.; Blake, J.A.; Blumenthal, A.; Bodega, B.; Bonetti, A.; Briggs, J.; Brombacher, F.; Burroughs, A.M.; Califano, A.; Cannistraci, C.V.; Carbajo, D.; Chen, Y.; Chierici, M.; Ciani, Y.; Clevers, H.C.; , E. dalla; Davis, C.A.; Detmar, M.; Diehl, A.D.; Dohi, T.; Drablos, F.; Edge, A.S.B.; Edinger, M.; Ekwall, K.; Endoh, M.; Enomoto, H.; Fagiolini, M.; Fairbairn, L.; Fang, H.; Farach-Carson, M.C.; Faulkner, G.J.; Favorov, A.V.; Fisher, M.E.; Frith, M.C.; Fujita, R.; Fukuda, S.; Furlanello, C.; Furuno, M.; Furusawa, J.; Geijtenbeek, T.B.; Gibson, A.P.; Gingeras, T.; Goldowitz, D.; Gough, J.; Guhl, S.; Guler, R.; Gustincich, S.; Ha, T.J.; Hamaguchi, M.; Hara, M.; Harbers, M.; Harshbarger, J.; Hasegawa, A.; Hasegawa, Y.; Hashimoto, T.; Herlyn, M.; Hitchens, K.J.; Sui, S.J.H.; Hofmann, O.M.; Hoof, I.; Hori, F.; Huminiecki, L.; Iida, K.; Ikawa, T.; Jankovic, B.R.; Jia, H.; Joshi, A.; Jurman, G.; Kaczkowski, B.; Kai, C.; Kaida, K.; Kaiho, A.; Kajiyama, K.; Kanamori-Katayama, M.; Kasianov, A.; Kasukawa, T.; Katayama, S.; Kato, S.; Kawaguchi, S.; Kawamoto, H.; Kawamura, Y.I.; Kawashima, T.; Kempfle, J.S.; Kenna, T.J.; Kere, J.; Khachigian, L.M.; Kitamura, T.; Klinken, S.P.; Knox, A.J.; Kojima, M.; Kojima, S.; Kondo, N.; Koseki, H.; Koyasu, S.; Krampitz, S.; Kubosaki, A.; Kwon, A.T.; Laros, J.F.J.; Lee, W.; Lennartsson, A.; Li, K.; Lilje, B.; Lipovich, L.; Mackay-sim, A.; Manabe, R.; Mar, J.C.; Marchand, B.; Mathelier, A.; Mejhert, N.; Meynert, A.; Mizuno, Y.; Morais, D.A.D.; Morikawa, H.; Morimoto, M.; Moro, K.; Motakis, E.; Motohashi, H.; Mummery, C.L.; Murata, M.; Nagao-Sato, S.; Nakachi, Y.; Nakahara, F.; Nakamura, T.; Nakamura, Y.; Nakazato, K.; Nimwegen, E. van; Ninomiya, N.; Nishiyori, H.; Noma, S.; Nozaki, T.; Ogishima, S.; Ohkura, N.; Ohmiya, H.; Ohno, H.; Ohshima, M.; Okada-Hatakeyama, M.; Okazaki, Y.; Orlando, V.; Ovchinnikov, D.A.; Pain, A.; Passier, R.; Patrikakis, M.; Persson, H.; Piazza, S.; Prendergast, J.G.D.; Rackham, O.J.L.; Ramilowski, J.A.; Rashid, M.; Ravasi, T.; Rizzu, P.; Roncador, M.; Roy, S.; Rye, M.B.; Saijyo, E.; Sajantila, A.; Saka, A.; Sakaguchi, S.; Sakai, M.; Sato, H.; Satoh, H.; Savvi, S.; Saxena, A.; Schneider, C.; Schultes, E.A.; Schulze-Tanzil, G.G.; Schwegmann, A.; Sengstag, T.; Sheng, G.J.; Shimoji, H.; Shimoni, Y.; Shin, J.W.; Simon, C.; Sugiyama, D.; Sugiyama, T.; Suzuki, M.; Suzuki, N.; Swoboda, R.K.; Hoen, P.A.C. 't; Tagami, M.; Takahashi, N.; Takai, J.; Tanaka, H.; Tatsukawa, H.; Tatum, Z.; Thompson, M.; Toyoda, H.; Toyoda, T.; Valen, E.; Wetering, M. van de; Berg, L.M. van den; Verardo, R.; Vijayan, D.; Vorontsov, I.E.; Wasserman, W.W.; Watanabe, S.; Wells, C.A.; Winteringham, L.N.; Wolvetang, E.; Wood, E.J.; Yamaguchi, Y.; Yamamoto, M.; Yoneda, M.; Yonekura, Y.; Yoshida, S.; Zabierowski, S.E.; Zhang, P.G.; Zhao, X.B.; Zucchelli, S.; Summers, K.M.; Suzuki, H.; Daub, C.O.; Kawai, J.; Heutink, P.; Hide, W.; Freeman, T.C.; Lenhard, B.; Bajic, V.B.; Taylor, M.S.; Makeev, V.J.; Sandelin, A.; Hume, D.A.; Carninci, P.; Hayashizaki, Y.; FANTOM Consortium & RIKEN PMI CLST DGT (2014), A promoter-level mammalian expression atlas, Nature 507(7493): 462-+.
- Orlova, V.V.; Drabsch, Y.; Freund, C.; Petrus-Reurer, S.; Hil, F.E. van den; Muenthaisong, S.; Dijke, P. ten & Mummery, C.L. (2014), Functionality of Endothelial Cells and Pericytes From Human Pluripotent Stem Cells Demonstrated in Cultured Vascular Plexus and Zebrafish Xenografts, Arteriosclerosis, Thrombosis, and Vascular Biology 34(1): 177-+.
- Liu, Z.; Lebrin, F.; Maring, J.A.; Driesche, S. van den; Brink, S. van der; Dinther, M. van; Thorikay, M.; Martin, S.; Kobayashi, K.; Hawinkels, L.J.A.C.; Meeteren, L.A. van; Pardali, E.; Korving, J.; Letarte, M.; Arthur, H.M.; Theuer, C.; Goumans, M.J.; Mummery, C. & Dijke, P. ten (2014), ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced Angiogenesis, PLoS ONE 9(1).
- Casini, S.; Bellin, M.; Davis, R.P.; Aniello, C. d'; Haas, J.; Ward-van Oostwaard, D.; Tertoolen, L.G.J.; Laugwitz, K.L.; Moretti, A. & Mummery, C.L. (2014), Isogenic Sets of Human Pluripotent Stem Cells as Model of LQT2 Syndrome, Biophysical Journal 106(2): 552A-553A.
- Meer, A.D. van der; Orlova, V.V.; Dijke, P. ten; Berg, A. van den & Mummery, C.L. (2013), Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device, Lab on a Chip 13(18): 3562-3568.
- Birket, M.J.; Casini, S.; Kosmidis, G.; Elliott, D.A.; Gerencser, A.A.; Baartscheer, A.; Schumacher, C.; Mastroberardino, P.G.; Elefanty, A.G.; Stanley, E.G. & Mummery, C.L. (2013), PGC-1 alpha and Reactive Oxygen Species Regulate Human Embryonic Stem Cell-Derived Cardiomyocyte Function, Stem Cell Reports 1(6): 560-574.
- Bellin, M.; Casini, S.; Davis, R.P.; D'Aniello, C.; Haas, J.; Ward-van Oostwaard, D.; Tertoolen, L.G.J.; Jung, C.B.; Elliott, D.A.; Welling, A.; Laugwitz, K.L.; Moretti, A. & Mummery, C.L. (2013), Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome, EMBO Journal 32(24): 3161-3175.
- Moretti, A.; Laugwitz, K.L.; Dorn, T.; Sinnecker, D. & Mummery, C. (2013), Pluripotent Stem Cell Models of Human Heart Disease, Cold Spring Harbor perspectives in medicine 3(11).
- Yi, B.A.; Mummery, C.L. & Chien, K.R. (2013), Direct Cardiomyocyte Reprogramming: A New Direction for Cardiovascular Regenerative Medicine, Cold Spring Harbor perspectives in medicine 3(9).
- Davis, R.P.; Nemes, C.; Varga, E.; Freund, C.; Kosmidis, G.; Gkatzis, K.; Jong, D. de; Szuhai, K.; Dinnyes, A. & Mummery, C.L. (2013), Generation of induced pluripotent stem cells from human foetal fibroblasts using the Sleeping Beauty transposon gene delivery system, Differentiation 86(1-2): 30-37.
- Braam, S.; Langenberg, K.; Rohrbacher, J.; Grandela, K.C.; Mummery, C.L.; Towart, R.; Cik, M.; Diels, A.; Lu, H.R. & Gallacher, D.J. (2013), Cellular assays for monitoring cardiomyocyte electrophysiology, Journal of Pharmacological and Toxicological Methods 68(1): E9-E9.
- Ribeiro, M.C.; Hoorn, H. van; Monshouwer-Kloots, J.J.; Mummery, C.L.; Schmidt, T. & Passier, R. (2013), Studying Structural And Contractility Defects Of Cardiomyocytes In An In Vitro Model Of Human Hypertrophic Cardiomyopathy, Circulation Research 113(4).
- Mummery, C. (2013), Cardiomyocytes from human pluripotent stem cells: the new patient in safety pharmacology, drug discovery and disease, FEBS Journal 280: 441-442.
- Spijker, H.S.; Ravelli, R.B.G.; Mommaas-Kienhuis, A.M.; Apeldoorn, A.A. van; Engelse, M.A.; Zaldumbide, A.; Bonner-Weir, S.; Rabelink, T.J.; Hoeben, R.C.; Clevers, H.; Mummery, C.L.; Carlotti, F. & Koning, E.J.P. de (2013), Conversion of Mature Human beta-Cells Into Glucagon-Producing alpha-Cells, Diabetes 62(7): 2471-2480.
- Mummery, C.L. & Roelen, B.A.J. (2013), STEM CELLS Cloning human embryos, Nature 498(7453): 174-175.
- Lensch, M.W. & Mummery, C.L. (2013), From Stealing Fire to Cellular Reprogramming: A Scientific History Leading to the 2012 Nobel Prize, Stem Cell Reports 1(1): 5-17.
- Mummery, C. (2013), Cardiomyocytes from human pluripotent stem cells in safety pharmacology, drug discovery and disease, Human Gene Therapy 24(5): A8-A8.
- Bianco, P.; Barker, R.; Brustle, O.; Cattaneo, E.; Clevers, H.; Daley, G.Q.; Luca, M. de; Goldstein, L.; Lindvall, O.; Mummery, C.; Robey, P.G.; Brito, C.S.D.E. & Smith, A. (2013), Regulation of stem cell therapies under attack in Europe: for whom the bell tolls, EMBO Journal 32(11): 1489-1495.
- Mummery, C.L. & Lee, R.T. (2013), Is heart regeneration on the right track?, Nature Medicine 19(4): 412-413.
- Garbern, J.C.; Mummery, C.L. & Lee, R.T. (2013), Model Systems for Cardiovascular Regenerative Biology, Cold Spring Harbor perspectives in biology 5(4).
- Garbern, J.C.; Mummery, C.L. & Lee, R.T. (2013), Model Systems for Cardiovascular Regenerative Biology, Cold Spring Harbor perspectives in medicine 3(4).
- Dambrot, C.; Pas, S. van de; Zijl, L. van; Brandl, B.; Wang, J.W.; Schalij, M.J.; Hoeben, R.C.; Atsma, D.E.; Mikkers, H.M.; Mummery, C.L. & Freund, C. (2013), Polycistronic lentivirus induced pluripotent stem cells from skin biopsies after long term storage, blood outgrowth endothelial cells and cells from milk teeth, Differentiation 85(3): 101-109.
- Braam, S.R.; Tertoolen, L.; Casini, S.; Matsa, E.; Lu, H.R.; Teisman, A.; Passier, R.; Denning, C.; Gallacher, D.J.; Towart, R. & Mummery, C.L. (2013), Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes., Stem Cell Research 10(1): 48-56.
- Rossant, J. & Mummery, C. (2012), PHYSIOLOGY OR MEDICINE Mature cells can be rejuvenated, Nature 492(7427): 56-56.
- Bellin, M.; Marchetto, M.C.; Gage, F.H. & Mummery, C.L. (2012), Induced pluripotent stem cells: the new patient?, Nature Reviews Molecular Cell Biology 13(11): 713-726.
- Bellin, M.; Marchetto, M.C.; Gage, F.H. & Mummery, C.L. (2012), Induced pluripotent stem cells: the new patient?, Nature Reviews Molecular Cell Biology 13(11): 713-26.
- Sideras, P.; Stavropoulos, A.; Giaglis, S.; Apostolou, E.; Monteiro, R.; Lopes, S.M.C.D.; Chen, H.Y.; Stripp, B.R.; Mummery, C.; Andreakos, E. & Sountoulidis, A. (2012), ACTIVATION OF THE CANONICAL BONE MORPHOGENETIC PROTEIN (BMP) PATHWAY DURING LUNG MORPHOGENESIS AND ADULT LUNG TISSUE REPAIR.
- Chien, K.R.; Yi, B.A.; Xu, H.S. & Mummery, C.L. (2012), Cardiomyocyte reprogramming and the new age of cellular alchemy, Journal of Molecular and Cellular Cardiology 53(3): 311-313.
- Mummery, C. (2012), Pioneer in Cardiovascular Stem Cell Research: Christine Mummery, BSc, PhD, Circulation 126(12): F67-F71.
- Dambrot, A.; Braam, S.R.; Freund, C.M.A.H.; Pas, S. van de; Oostwaard, D.W.V.; Atsma, D.E. & Mummery, C.L. (2012), Human induced pluripotent stem cells as in vitro model for hypertrophic cardiomyopathy, European Heart Journal 33: 22-22.
- Sountoulidis, A.; Stavropoulos, A.; Giaglis, S.; Apostolou, E.; Monteiro, R.; Lopes, S.M.C.D.; Chen, H.Y.; Stripp, B.R.; Mummery, C.; Andreakos, E. & Sideras, P. (2012), Activation of the Canonical Bone Morphogenetic Protein (BMP) Pathway during Lung Morphogenesis and Adult Lung Tissue Repair, PLoS ONE 7(8): -.
- Mummery, C.L.; Zhang, J.H.; Ng, E.S.; Elliott, D.A.; Elefanty, A.G. & Kamp, T.J. (2012), Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells to Cardiomyocytes A Methods Overview, Circulation Research 111(3): 344-358.
- Mummery, C.L.; Zhang, J.H.; Ng, E.S.; Elliott, D.A.; Elefanty, A.G. & Kamp, T.J. (2012), Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview., Circulation Research 111(3): 344-58.
- Davis, R.P.; Casini, S.; Berg, C.W. van den; Hoekstra, M.; Remme, C.A.; Dambrot, C.; Salvatori, D.; Ward-van Oostwaard, D.; Wilde, A.A.M.; Bezzina, C.R.; Verkerk, A.O.; Freund, C. & Mummery, C.L. (2012), Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease., Circulation 125(25): 3079-91.
- Davis, R.P.; Casini, S.; Berg, C.W. van den; Hoekstra, M.; Remme, C.A.; Dambrot, C.; Salvatori, D.; Ward-van Oostwaard, D.; Wilde, A.A.M.; Bezzina, C.R.; Verkerk, A.O.; Freund, C. & Mummery, C.L. (2012), Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease, Circulation 125(25): 3079-+.
- Kraushaar, U.; Meyer, T.; Hess, D.; Gepstein, L.; Mummery, C.L.; Braam, S.R. & Guenther, E. (2012), Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models, Expert Opinion on Drug Safety 11(2): 285-298.
- Hoof, D. van; Krijgsveld, J. & Mummery, C. (2012), Proteomic Analysis of Stem Cell Differentiation and Early Development, Cold Spring Harbor perspectives in biology 4(3): -.
- Hoof, D. van; Krijgsveld, J. & Mummery, C. (2012), Proteomic analysis of stem cell differentiation and early development., Cold Spring Harbor perspectives in biology 4(3).
- Moya, I.M.; Umans, L.; Maas, E.; Pereira, P.N.G.; Beets, K.; Francis, A.; Sents, W.; Robertson, E.J.; Mummery, C.L.; Huylebroeck, D. & Zwijsen, A. (2012), Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades, Developmental Cell 22(3): 501-514.
- Majesky, M.W. & Mummery, C.L. (2012), Smooth muscle diversity from human pluripotent cells, Nature Biotechnology 30(2): 152-154.
- Freund, C.; Davis, R.P.; Gkatzis, K.; Ward-van Oostwaard, D. & Mummery, C.L. (2012), The first reported generation of human induced pluripotent stem cells (iPS cells) and iPS cell-derived cardiomyocytes in the Netherlands, Netherlands Heart Journal 20: 95-98.
- Casini, S.; Davis, R.P.; Berg, C.W. van den; Remme, C.A.; Dambrot, C.; Ward-van Oostwaard, D.; Wilde, A.A.M.; Bezzina, C.R.; Verkerk, A.O.; Freund, C. & Mummery, C.L. (2012), Pluripotent Stem Cell Models of a Cardiac Sodium Channelopathy, Biophysical Journal 102(3): 540A-540A.
- Eldik, W. van; Beqqali, A.; Monshouwer-Kloots, J.; Mummery, C. & Passier, R. (2011), Cytoskeletal heart-enriched actin-associated protein (CHAP) is expressed in striated and smooth muscle cells in chick and mouse during embryonic and adult stages., International Journal of Developmental Biology 55(6): 649-55.
- Morris, E.; Chrobak, I.; Bujor, A.; Hant, F.; Mummery, C.; Dijke, P. ten & Trojanowska, M. (2011), Endoglin Promotes TGF-beta/Smad1 Signaling in Scleroderma Fibroblasts, Journal of Cellular Physiology 226(12): 3340-3348.
- Elliott, D.A.; Braam, S.R.; Koutsis, K.; Ng, E.S.; Jenny, R.; Lagerqvist, E.L.; Biben, C.; Hatzistavrou, T.; Hirst, C.E.; Yu, Q.C.; Skelton, R.J.P.; Oostwaard, D.W.V.; Lim, S.M.; Khammy, O.; Li, X.L.; Hawes, S.M.; Davis, R.P.; Goulburn, A.L.; Passier, R.; Prall, O.W.J.; Haynes, J.M.; Pouton, C.W.; Kaye, D.M.; Mummery, C.L.; Elefanty, A.G. & Stanley, E.G. (2011), NKX2-5eGFPw hESCs for isolation of human cardiac progenitors and cardiomyocytes, Nature Methods 8(12): 1037-+.
- Amps, K.; Andrews, P.W.; Anyfantis, G.; Armstrong, L.; Avery, S.; Baharvand, H.; Baker, J.; Baker, D.; Munoz, M.B.; Beil, S.; Benvenisty, N.; Ben-Yosef, D.; Biancotti, J.C.; Bosman, A.; Brena, R.M.; Brison, D.; Caisander, G.; Camarasa, M.V.; Chen, J.M.; Chiao, E.; Choi, Y.M.; Choo, A.B.H.; Collins, D.; Colman, A.; Crook, J.M.; Daley, G.Q.; Dalton, A.; Sousa, P.A. de; Denning, C.; Downie, J.; Dvorak, P.; Montgomery, K.D.; Feki, A.; Ford, A.; Fox, V.; Fraga, A.M.; Frumkin, T.; Ge, L.; Gokhale, P.J.; Golan-Lev, T.; Gourabi, H.; Gropp, M.; Lu, G.X.; Hampl, A.; Harron, K.; Healy, L.; Herath, W.; Holm, F.; Hovatta, O.; Hyllner, J.; Inamdar, M.S.; Irwanto, A.K.; Ishii, T.; Jaconi, M.; Jin, Y.; Kimber, S.; Kiselev, S.; Knowles, B.B.; Kopper, O.; Kukharenko, V.; Kuliev, A.; Lagarkova, M.A.; Laird, P.W.; Lako, M.; Laslett, A.L.; Lavon, N.; Lee, D.R.; Lee, J.E.; Li, C.L.; Lim, L.S.; Ludwig, T.E.; Ma, Y.; Maltby, E.; Mateizel, I.; Mayshar, Y.; Mileikovsky, M.; Minger, S.L.; Miyazaki, T.; Moon, S.Y.; Moore, H.; Mummery, C.; Nagy, A.; Nakatsuji, N.; Narwani, K.; Oh, S.K.W.; Oh, S.K.; Olson, C.; Otonkoski, T.; Pan, F.; Park, I.H.; Pells, S.; Pera, M.F.; Pereira, L.V.; Qi, O.; Raj, G.S.; Reubinoff, B.; Robins, A.; Robson, P.; Rossant, J.; Salekdeh, G.H.; Schulz, T.C.; Sermon, K.; Mohamed, J.S.; Shen, H.; Sherrer, E.; Sidhu, K.; Sivarajah, S.; Skottman, H.; Spits, C.; Stacey, G.N.; Strehl, R.; Strelchenko, N.; Suemori, H.; Sun, B.W.; Suuronen, R.; Takahashi, K.; Tuuri, T.; Venu, P.; Verlinsky, Y.; Ward-van Oostwaard, D.; Weisenberger, D.J.; Wu, Y.; Yamanaka, S.; Young, L.; Zhou, Q. & Int Stem Cell Initiative (2011), Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage, Nature Biotechnology 29(12): 1132-U113.
- Mummery, C.L. & Passier, R. (2011), New perspectives on regeneration of the heart., Circulation Research 109(8): 828-9.
- Davis, R.P.; Berg, C.W. van den; Casini, S.; Braam, S.R. & Mummery, C.L. (2011), Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development., Trends in Molecular Medicine 17(9): 475-84.
- Davis, R.P.; Berg, C.W. van den; Casini, S.; Braam, S.R. & Mummery, C.L. (2011), Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development, Trends in Molecular Medicine 17(9): 475-484.
- Ramkisoensing, A.A.; Pijnappels, D.A.; Askar, S.F.A.; Passier, R.; Swildens, J.; Goumans, M.J.; Schutte, C.I.; Vries, A.A.F. de; Scherjon, S.; Mummery, C.L.; Schalij, M.J. & Atsma, D.E. (2011), Human Embryonic and Fetal Mesenchymal Stem Cells Differentiate toward Three Different Cardiac Lineages in Contrast to Their Adult Counterparts, PLoS ONE 6(9).
- Mummery, C. & Goumans, M.J. (2011), Shedding new light on the mechanism underlying stem cell therapy for the heart.
- Staal, F.J.T.; Baum, C.; Cowan, C.; Dzierzak, E.; Hacein-Bey-Abina, S.; Karlsson, S.; Lapidot, T.; Lemischka, I.; Mendez-Ferrer, S.; Mikkers, H.; Moore, K.; Moreno, E.; Mummery, C.L.; Robin, C.; Suda, T.; Pel, M. van; Brink, G.V.; Zwaginga, J.J. & Fibbe, W.E. (2011), Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications., Leukemia 25(7): 1095-102.
- Staal, F.J.T.; Baum, C.; Cowan, C.; Dzierzak, E.; Hacein-Bey-Abina, S.; Karlsson, S.; Lapidot, T.; Lemischka, I.; Mendez-Ferrer, S.; Mikkers, H.; Moore, K.; Moreno, E.; Mummery, C.L.; Robin, C.; Suda, T.; Pel, M. van; Brink, G.V.; Zwaginga, J.J. & Fibbe, W.E. (2011), Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications, Leukemia 25(7): 1095-1102.
- Mummery, C. (2011), Induced pluripotent stem cells--a cautionary note.
- Leeuwis, J.W.; Nguyen, T.Q.; Lopes, S.M.C.D.; Giezen, D.M. van der; Ven, K. van der; Rouw, P.J.H.; Offerhaus, G.J.A.; Mummery, C.L. & Goldschmeding, R. (2011), Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys, Journal of Pathology 224(1): 121-132.
- Mummery, C.; Westgren, M. & Sermon, K. (2011), Current controversies in prenatal diagnosis 1: is stem cell therapy ready for human fetuses?, Prenatal Diagnosis 31(3): 228-30.
- Fujiwara, M.; Yan, P.S.; Otsuji, T.G.; Narazaki, G.; Uosaki, H.; Fukushima, H.; Kuwahara, K.; Harada, M.; Matsuda, H.; Matsuoka, S.; Okita, K.; Takahashi, K.; Nakagawa, M.; Ikeda, T.; Sakata, R.; Mummery, C.L.; Nakatsuji, N.; Yamanaka, S.; Nakao, K. & Yamashita, J.K. (2011), Induction and Enhancement of Cardiac Cell Differentiation from Mouse and Human Induced Pluripotent Stem Cells with Cyclosporin-A, PLoS ONE 6(2).
- Dambrot, C.; Passier, R.; Atsma, D. & Mummery, C.L. (2011), Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models, Biochemical Journal 434: 25-35.
- Dambrot, C.; Passier, R.; Atsma, D. & Mummery, C.L. (2011), Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models., Biochemical Journal 434(1): 25-35.
- Mummery, C.; Westgren, M. & Sermon, K. (2011), Current controversies in prenatal diagnosis 1: is stem cell therapy ready for human fetuses?, Prenatal Diagnosis.
- Braam SR, Denning C & Mummery CL (2010), Genetic manipulation of human embryonic stem cells in serum and feeder-free media., Methods in Molecular Biology 584: 413-23.
- Lebrin, F.; Freund, C.; Braam, S.; Passier, R.; Laake, L. van; Ward, D.; Tertoolen, L.; Davis, R. & Mummery, C. (2010), Cardiovascular derivatives of embryonic stem cells in cardiac repair and drug discovery, Differentiation 80: S12-S12.
- Kearns-Jonker, M.; Dai, W.D.; Gunthart, M.; Girish, N.; Pera, M.; Mummery, C. & Kloner, R.A. (2010), Genetically Engineered Mesenchymal Stem Cells Confer Beneficial Effects on Both Co-transplanted Human Embryonic Stem Cell Derived Cardiomyocytes as well as the Recipient Heart, Circulation 122(21).
- Passier, R. & Mummery, C. (2010), Getting to the heart of the matter: direct reprogramming to cardiomyocytes., Cell Stem Cell 7(2): 139-41.
- Beqqali, A.; Monshouwer-Kloots, J.; Monteiro, R.; Welling, M.; Bakkers, J.; Ehler, E.; Verkleij, A.; Mummery, C. & Passier, R. (2010), CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function, Journal of Cell Science 123(7): 1141-1150.
- Lebrin, F.; Srun, S.; Raymond, K.; Martin, S.; Brink, S. van den; Freitas, C.; Breant, C.; Mathivet, T.; Larrivee, B.; Thomas, J.L.; Arthur, H.M.; Westermann, C.J.J.; Disch, F.; Mager, J.J.; Snijder, R.J.; Eichmann, A. & Mummery, C.L. (2010), Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia, Nature Medicine 16(4): 420U101.
- Koyanagi, M.; Iwasaki, M.; Rupp, S.; Tedesco, F.S.; Yoon, C.H.; Boeckel, J.N.; Trauth, J.; Schutz, C.; Ohtani, K.; Goetz, R.; Iekushi, K.; Bushoven, P.; Momma, S.; Mummery, C.; Passier, R.; Henschler, R.; Akintuerk, H.; Schranz, D.; Urbich, C.; Galvez, B.G.; Cossu, G.; Zeiher, A.M. & Dimmeler, S. (2010), Sox2 Transduction Enhances Cardiovascular Repair Capacity of Blood-Derived Mesoangioblasts, Circulation Research 106(7): 1290U281.
- Mummery, C.L.; Davis, R.P. & Krieger, J.E. (2010), Challenges in Using Stem Cells for Cardiac Repair, Science Translational Medicine 2(27).
- Hoof, D. van; Dormeyer, W.; Braam, S.R.; Passier, R.; Monshouwer-Kloots, J.; Ward-van Oostwaard, D.; Heck, A.J.R.; Krijgsveld, J. & Mummery, C.L. (2010), Identification of Cell Surface Proteins for Antibody-Based Selection of Human Embryonic Stem Cell-Derived Cardiomyocytes, Journal of Proteome Research 9(3): 1610-1618.
- Braam, S.R.; Tertoolen, L.; Stolpe, A. van de; Meyer, T.; Passier, R. & Mummery, C.L. (2010), Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes., Stem Cell Research 4(2): 107-16.
- Braam, S.R.; Nauw, R.; Ward-van Oostwaard, D.; Mummery, C.; Passier, R.; Beyar, R. & Landesberg, A. (2010), Inhibition of ROCK improves survival of human embryonic stem cell-derived cardiomyocytes after dissociation., Annals of the New York Academy of Sciences 1188: 52-7.
- Post, S.; Smits, A.M.; Broek, A.J. van den; Sluijter, J.P.G.; Hoefer, I.E.; Janssen, B.J.; Snijder, R.J.; Mager, J.J.; Pasterkamp, G.; Mummery, C.L.; Doevendans, P.A. & Goumans, M.J. (2010), Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance, Cardiovascular Research 85(3): 494-502.
- Laake, L.W. van; Donselaar, E.G. van; Monshouwer-Kloots, J.; Schreurs, C.; Passier, R.; Humbel, B.M.; Doevendans, P.A.; Sonnenberg, A.; Verkleij, A.J. & Mummery, C.L. (2010), Extracellular matrix formation after transplantation of human embryonic stem cell-derived cardiomyocytes, Cellular and Molecular Life Sciences 67(2): 277-290.
- Freund, C.; Davis, R.P.; Gkatzis, K.; Ward-van Oostwaard, D. & Mummery, C.L. (2010), The first reported generation of human induced pluripotent stem cells (iPS cells) and iPS cell-derived cardiomyocytes in the Netherlands, Netherlands Heart Journal 18(1): 51-54.
- Andrews PW, Arias-Diaz J, Auerbach J, Alvarez M, Ahrlund-Richter L, Baker D, Benvenisty N, Ben-Josef D, Blin G, Borghese L, Borstlap J, Bruce K, Brustle O, Buckle R, Camby C, Choo A, Chen W, Collins D, Colman A & Crombie C (2009), Consensus Guidance for Banking and Supply of Human Embryonic Stem Cell Lines for Research Purposes, Stem Cell Reviews and Reports 5(4): 301-314.
- van Laake LW, Passier R, den Ouden K, Schreurs C, Monshouwer-Kloots J, Ward-van Oostwaard D, van Echteld CJ, Doevendans PA & Mummery CL (2009), Improvement of mouse cardiac function by hESC-derived cardiomyocytes correlates with vascularity but not graft size, Stem Cell Research 3(2-3): 106-112.
- Nijmeijer RM, Leeuwis JW, DeLisio A, Mummery CL & Lopes SMCD (2009), Visceral endoderm induces specification of cardiomyocytes in mice, Stem Cell Research 3(2-3): 170-178.
- Braam SR, Passier R & Mummery CL (2009), Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery, Trends in Pharmacological Sciences 30(10): 536-545.
- Van Hoof D, Munoz J, Braam SR, Pinkse MWH, Linding R, Heck AJR, Mummery CL & Krijgsveld J (2009), Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells, Cell Stem Cell 5(2): 214-226.
- Smits AM, van Laake LW, den Ouden K, Schreurs C, Szuhai K, van Echteld CJ, Mummery CL, Doevendans PA & Goumans MJ (2009), Human cardiomyocyte progenitor cell transplantation preserves long-term function of the infarcted mouse myocardium, Cardiovascular Research 83(3): 527-535.
- Itoh F, Itoh S, Carvalho RLC, Adachi T, Ema M, Goumans MJ, Larsson J, Karlsson S, Takahashi S & Mummery CL (2009), Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation, Laboratory Investigation 89(7): 800-810.
- Freund C & Mummery CL (2009), Prospects for Pluripotent Stem Cell-Derived Cardiomyocytes in Cardiac Cell Therapy and as Disease Models, Journal of Cellular Biochemistry 107(4): 592-599.
- Beqqali A, van Eldik W, Mummery C & Passier R (2009), Human stem cells as a model for cardiac differentiation and disease, Cellular and Molecular Life Sciences 66(5): 800-813.
- Beqqali A, van Eldik W, Mummery C & Passier R (2009), Human stem cells as a model for cardiac differentiation and disease., Cellular and Molecular Life Sciences 66(5): 800-13.
- Smits Anke M., van Laake Linda W., den Ouden Krista, Schreurs Chantal, van Echteld Coos J., Mummery Christine L., Doevendans Pieter A. & Goumans Marie-Jose (2008), Human Cardiomyocyte Progenitor Cells Regenerate Infarcted Myocardium and Preserve Long-Term Cardiac Function In Mice, Circulation 118(18): S499-S499.
- Van Hoof Dennis, Heck Albert J. R., Krijgsveld Jeroen & Mummery Christine L. (2008), Proteomics and human embryonic stem cells, Stem Cell Research 1(3): 169-182.
- Braam SR, Zeinstra L, Litjens S, Ward-van Oostwaard D, van den Brink S, van Laake L, Lebrin F, Kats P, Hochstenbach R, Passier R, Sonnenberg A & Mummery CL (2008), Recombinant vitronectin is a functionally defined substrate that supports human embryonic stem cell self-renewal via alpha V beta 5 integrin, STEM CELLS 26(9).
- Monteiro RM, Lopes SMCD, Bialecka M, de Boer S, Zwijsen A & Mummery CL (2008), Real time monitoring of BMP Smads transcriptional activity during mouse development, genesis 46(7).
- Braam SR, Denning C, van den Brink S, Kats P, Hochstenbach R, Passier R & Mummery CL (2008), Improved genetic manipulation of human embryonic stem cells, Nature Methods 5(5).
- Passier R, van Laake LW & Mummery CL (2008), Stem-cell-based therapy and lessons from the heart, Nature 453(7193).
- van Laake LW, Passier R, Doevendans PA & Mummery CL (2008), Human embryonic stem cell-derived cardiomyocytes and cardiac repair in rodents, Circulation Research 102(9).
- Monteiro R, van Dinther M, Bakkers J, Wilkinson R, Patient R, ten Dijke P & Mummery C (2008), Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish, Developmental Biology 315(1).
- Braam SR, Denning C, Matsa E, Young LE, Passier R & Mummery CL (2008), Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification, Nature Protocols 3(9).
- Van Hoof D, Braam SR, Dormeyer W, Oostwaard DWV, Heck AJR, Krijgsveld J & Mummery CL (2008), Feeder-Free Monolayer Cultures of Human Embryonic Stem Cells Express an Epithelial Plasma Membrane Protein Profile, STEM CELLS 26(11).
- Carvalho RLC, Itoh F, Goumans MJ, Lebrin F, Kato M, Takahashi S, Ema M, Itoh S, van Rooijen M, Bertolino P, ten Dijke P & Mummery CL (2007), Compensatory signalling induced in the yolk sac vasculature by deletion of TGF beta receptors in mice, Journal of Cell Science 120(24).
- van Bezooijen RL, DeRuiter MC, Vilain N, Monteiro RM, Visser A, van der Wee-Pals L, van Munsteren CJ, Hogendoorn PCW, Aguet M, Mummery CL, Papapoulos SE, Ten Dijke P & Lowik CWGM (2007), SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development, Developmental Dynamics 236(2).
- van Laake LW, van den Driesche S, Post S, Feijen A, Jansen MA, Driessens MH, Mager JJ, Snijder RJ, Westermann CJJ, Doevendans PA, van Echteld CJA, ten Dijke P, Arthur HM, Goumans MJ, Lebrin F & Mummery CL (2006), Endoglin has a crucial role in blood cell-mediated vascular repair, Circulation 114(21).
- van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Pradere JP, Pettit TR, Wakelam MJO, Saulnier-Blache JS, Mummery CL, Moolenaar WH & Jonkers J (2006), Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development, Molecular and Cellular Biology 26(13): 5015-5022.
- de Sousa Lopes SMC, Hassink RJ, Feijen A, van Rooijen MA, Doevendans PA, Tertoolen L, de la Rivere AB & Mummery CL (2006), Patterning the heart, a template for human cardiomyocyte development.
- Lopes SMCD, Roelen BAJ, Monteiro RM, Emmens R, Lin HY, Li E, Lawson KA & Mummery CL (2004), BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo, Genes and Development 18(15): 1838-1849.
- Koop EA, Lopes SMCD, Feiken E, Bluyssen HAR, Van Der Valk M, Voest EE, Mummery CL, Moolenaar WH & Gebbink MFBG (2003), Receptor protein tyrosine phosphatase mu expression as a marker for endothelial cell heterogeneity; analysis of RPTP mu gene expression using LacZ knock-in mice, International Journal of Developmental Biology 47(5): 345-354.
- Cachaco AS, Lopes SMCD, Kuikman I, Bajanca F, Abe K, Baudoin C, Sonnenberg A, Mummery CL & Thorsteinsdottir S (2003), Knock-in of integrin beta 1D affects primary but not secondary myogenesis in mice, DEVELOPMENT 130(8): 1659-1671.
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- Editor in Chief Stem Cell Reports
- Hoogleraar