Anna Vlachodimou is a Ph.D. student at the Division of Medicinal Chemistry and focusses on membrane transporters and binding kinetics.
I studied Pharmacy at the University of Patras, Greece, starting in 2008. During my undergraduate studies I gathered experience in multiple disciplines of Pharmaceutical Sciences by working as an intern in both community and hospital pharmacies. Next to my pharmacist experience I had the opportunity to perform an internship in the synthesis lab of the medicinal chemistry department, synthesizing Hymenialdesine analogues as CDK1 inhibitors.
This experience inspired me to follow the research-oriented master program of Biopharmaceutical Sciences at Leiden University, from 2013 till 2015. During my masters I performed two research internships together with a literature study. In my first 9-month internship at the LACDR division of Medicinal Chemistry, I worked on synthesizing long residence time antagonists of the human adenosine A 1 receptor. For my second internship I worked at Genmab, a biotech company, on developing and establishing an Image-based antibody-drug conjugates cytotoxicity assay.
After obtaining my Masters degree, I returned to the division of Medicinal Chemistry to start my PhD in Prof. IJzerman’s group with the focus on membrane transporters and binding kinetics. During these four years, I will focus on the study of association and dissociation of the ligand to and from its target, i.e. transport proteins, over time, aiming to gain insight on the concept of ligand-receptor residence time (RT) and provide detailed guidelines for development of new drugs targeting membrane transporters.