Professor Thomas Hankemeier and his international research team HYPERMARKER have received a 10m-euro grant from Horizon Europe and UK Research and Innovation.

Coen van Hasselt’s pharmacology group collaborated on a study recently published in the renowned Lancet Infectious Diseases. The international team mapped the antibiotic treatment of the life-threatening inflammatory reaction sepsis in newborn babies. They did this for low- and middle-income countries,…

Supervisor: Anna Vlachodimou

Ukrainian refugees are being allowed to work in the Netherlands straight away. So Why do other refugees sometimes have to wait years before they can work?

Dendritic cells (DC) play a prominent role in the priming of CD8(+) T cells. Vaccination is a promising treatment to boost tumor-specific CD8(+) T cells which is crucially dependent on adequate delivery of the vaccine to DC.

Chemist Gerjan de Bruin has designed a method of slowing down the degradation process of proteins in cells. This may contribute to new cancer medicines with fewer side-effects. PhD defence on 1 June.

An overview of the research at the Biologics Formulation group

Patients with skin diseases such as eczema and psoriasis, sometimes spend a lifetime searching for the right medication. To help these patients faster and better, scientists across the country are joining forces. The Next Generation ImmunoDermatology (NGID) project, with LACDR professor Robert Rissmann…

Promotor: Prof.dr. W. Jiskoot, Co-promotor: A. Kros

How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?

An international group of scientists has discovered that certain cells of our immune system – the so-called T cells – communicate with each other and work together as a team. To fight an infection they stimulate each other’s growth, but at the same time, they inhibit each other when there is a surplus…

Fungi germinating in the lungs of patients. Doesn’t sound too nice, does it? Luckily, humans can deal with this normally, and we are able to clear the infection before anything comes to harm. However, in people with health issues, Aspergillosis can cause a lot of damage, especially if the fungus becomes…

Can drug screening for tuberculosis treatment be made more efficient?

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The project 'Data use, online consumer needs, business strategies and regulatory response' aims to explore and examine the factors that impact upon the efficacy of information disclosure duties pertaining to customer data use in online business.

This project aims to explore and examine the factors that impact upon the efficacy of information disclosure duties pertaining to customer data use in online business.

We cover the entire spectrum from target identification to the evaluation of the efficacy and safety of novel medicines in clinical practice.

Supervisor: Natalia Ortiz Zacarías

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

PhD defence

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Supervisor: Indira Nederpelt

Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…

Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

How can preservice teachers be prepared for culturally responsive classroom management?

To what extent can contingent, formative feedback in lectures, facilitated by web-based ICT, increase students’ self-efficacy and (academic, behavioral, and cognitive) engagement? And how are self-efficacy and engagement influencing students’ performance and course evaluations?

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Lecture, Leiden Interdisciplinary Migration Seminar (LIMS)

A hot topic in educational sciences is whether and how reading medium (paper vs. screen) affects reading comprehension. Especially in the media – but also in schools – their appears to be a preference for texts presented on paper: Paper texts are thought to induce a more intensive reading strategy,…

The aim of this research is to gain insight into the approaches of learning to teach. Teacher learning processes, feedback in novice-expert interaction and the impact of the interaction are explored.

Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

This case study (in French)—conducted as part of the NWO/Clingendael Institute project ‘Plural Security Insights’—highlights how the dilemma of security provision in Tunisia is part of a crisis of trust between society and state institutions.

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Examining the therapeutic potential of new semisynthetic lipopeptide antibiotics

Acquiring and maintaining public support is frequently cited as an important requirement for governments fighting non-state actors. But how exactly can public support influence the course of counterterrorism campaigns and thereby contribute to an escalation or de-escalation of violence?

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Our team is involved in the translation and adaptation of several questionnaires, for research purposes. Information about each questionnaire is listed below.

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

PhD defence

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The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.