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The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.

Tiny selenium particles could have a therapeutic effect on ischemic brain strokes by promoting the recovery of brain damage. Pharmacologists, including Alireza Mashaghi from the Leiden Academic Centre for Drug Research discovered that selenium nanoparticles inhibit molecular mechanisms that are responsible…

What is the neurocognitive structure of human navigation ability? What different types of navigation impairment can be distinguished? How can navigation impairment best be diagnosed and treated? How can tools like serious gaming and virtual reality be used to diagnose and treat navigation impairment…

The Faculty of Medicine

Here, you can browse the publications of the Navigation Lab Leiden:

PhD defence

Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Promotor: Prof.dr. J. Kuiper

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Cardiovascular disease is the leading cause of death worldwide.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

Supervisor: Anna Vlachodimou

Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

The research group headed by Ilze Bot aims to elucidate the mechanisms that underlie atherosclerotic plaque destabilization, which is the key process that leads to acute cardiovascular syndromes such as a myocardial infarction or stroke.

Winning gold in speed skating at the Olympic Games is not just a matter of training hard; data science can also lend a hand. Jeroen van der Eb of the Leiden Institute of Advanced Computer Science (LIACS) developed the measuring skate for this purpose, with which he recently won the Nationale Sportinnovator…

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

Composer Paul Craenen (1972) is actually a pianist, but as part of his PhD ceremony, he performed a composition on PVC pipes. Craenen studies the position and role of the body in music. ‘I am interested in what precedes the resulting sound’.

Ilze Bot and Johan Kuiper have published in The Lancet: Study unveils how stress may increase risk of heart disease and stroke. Aso: The National Dutch newspaper 'NRC' has mentioned them in a column

Arteriosclerosis bears great similarities to autoimmune diseases. Researchers from Leiden University show this in a new study they published in the renowned scientific journal Nature Cardiovascular Research. 'This discovery suggests that treatment methods for autoimmune diseases might also be effective…

‘Tell me something I don’t know,’ said skating coach Jac Orie to Leiden data scientist Arno Knobbe. And he did. Knobbe and his colleagues now assist athletes in all kinds of ways with the help of data mining.

A multiple isotope approach to human-animal dynamics in the Lesser Antilles across the historical divide

The master's specialisation Clinical Neuropsychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

Eleven talented Leiden researchers with several years of research experience have been awarded a Vidi subsidy to set up or expand their own line of research.

Brain scanners have radically changed neurolinguistics. They are increasing our understanding of how the brain processes language. Professor Niels Schiller has produced a standard work on this.

Nederlanders met lage inkomens lopen tot 1,5 keer meer risico op het krijgen van een hartaanval of beroerte dan rijkere landgenoten. Bij Surinaamse Hindoestanen is dit risico 1,9 keer hoger. Dat blijkt uit onderzoek van het LUMC en het HagaZiekenhuis. Nederlandse artsen kijken tot nu toe niet naar deze…

Publication by: Anouk Wezel, Sabine Welten, Wida Razawy, Max Lagraauw, Margreet de Vries, Eveline Goossens, Martin Boonstra, Jaap Hamming, Ekambar Kandimalla, Johan Kuiper, Paul Quax, Yaël Nossent and Ilze Bot. Annals of Surgery. 2015;262:841-848.

The Heart Foundation has portrayed researchers Johan Kuiper and Ilze Bot of the Leiden Academic Centre for Drug Research (LACDR) who fight heart and brain infarcts in the lab.

University lecturer Andrew Gawthorpe argues in The Guardian that the Republican's new agenda for a second Trump term is more radical than the first. He says that they seek to take control of federal agencies by replacing civil servants with ‘American First footsoldiers’.

Minims are letters that are made up of short, vertical pen strokes, such as 'm', 'i', 'n' and 'u'. In Gothic script, there is often little distinction between letters composed of minims. Assistant professor of medieval literature Krista Murchison has written an article in History Today on the hidden…

In the future, computers will be able to base their decisions on intuition. Professor Jaap van den Herik, director of the Leiden Centre of Data Science, posed this statement today in his Valedictory Address at Tilburg University.

Amanda Foks (Division of BioTherapeutics) has been awarded a Horizon 2020, ERA-CVD joint transnational cardiovascular research grant. She will lead a consortium consisting of early career European scientists (Dimitrios Tsiantoulas, Medical University of Vienna, Austria; Julia Polansky-Biskup, Charité…

Dutch speedskaters have been winning the most medals in speed skating at the Winter Olympics for years. How? Based on their intuition. Scientist Jeroen van der Eb of the Data Mining & Sports group of the Leiden Institute of Advanced Computer Science (LIACS) wants speedskaters to adjust their irons based…

Want to sponsor scientific research by raising funds? You can now do just that via Leiden University's campaign platform acties.steunleiden.nl. A broad range of projects have already started, including for research on genetic diseases.

It might be possible to prevent atherosclerosis by changing the appearance of macrophages, cells of the immune system that for example digest foreign substances. In her PhD dissertation, Baoyan Ren examined several ways to do so.

Team Jumbo-Visma is going for gold at the World Championships this weekend in Salt Lake City. For this, they have worked on a new special training method. The Data Mining and Sports group of the Leiden Institute of Advanced Computer Science (LIACS) was involved in the development of this method.

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

Cardiovascular diseases are the leading cause of death across the world. Professor Johan Kuiper of Leiden University carries out research to develop a vaccine for arteriosclerosis, which is the main cause of cardiovascular diseases. With the aid of a European research grant of six million euros he is…

The Italian physicist Andrea Morello is one of the pioneers of the quantum revolution. He is currently doing research at the University of New South Wales in Sydney, but cherishes his time as a PhD candidate in Leiden.

Composer Paul Craenen (1972) is actually a pianist, but as part of his PhD ceremony, he performed a composition on PVC pipes. Craenen studies the position and role of the body in music. ‘I am interested in what precedes the resulting sound’.

Leiden archaeology is booming. Our archaeologists take part in major international projects covering not only the Netherlands but large areas of the globe. Caspar Reuvens (1793-1835) was also keen on this division: he had one foot in the Netherlands and the other in the Mediterranean world.

In her inaugural lecture on 11 September, Miranda van Eck, Professor of Cardiovascular and Metabolic Therapeutics, addressed her research related to developing medications to keep our blood vessels clean.

Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…

He studied Dutch Studies, did Dutch literature research for his internship, and worked at HEMA: Hungarian Márton Biró (26) came to the Netherlands on exchange and decided to stay.

By a stroke of luck, a team led by Dutch PhD student Martijn Oei has discovered a radio galaxy of at least 16 million lightyears long. The pair of plasma plumes is the largest structure made by a galaxy known thus far. The finding disproves some long-kept hypotheses about the growth of radio galaxie…