Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

Promotores: Bas Edixhoven, Jean-Benoit Bost, Co-promotor: Robin de Jong

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

Promotor: G. van Dijk

Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit

Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Promotor: S.M. Verduyn Lunel

The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.

On Thursday 2 May, the Institute of Security and Global Affairs (ISGA) of Leiden University hosted a guest lecture given by former NATO Assistant Secretary General for Emerging Security Challenges, Ambassador Sorin Ducaru.

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.

What tools can be applied to measure the output, outcome and impact of science communication efficiently and effectively?

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Human activity, such as pollution, may disturb the balance of living water systems, which has consequences for biodiversity, but also for other functions such as water purification. Leiden University maps living water systems using the most advanced technologies.

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

On Wednesday 5 June, Kalin Anev Janse, Secretary-General and Management Board Member of the European Stability Mechanism (ESM), was invited to give a lecture on 'Bridging decision-making: a new direction for Europe? Prioritising financial stability: the European Stability Mechanism and the Banking U…

Promotor: W. Jiskoot, Co-promotor: H.A. Every

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

PhD defence

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

Sarah Giest and Annemarie Samuels, both Assistant Professors at Leiden University, researched the quality and coverage of the data being collected for policiymakers to be used, specifically pertaining to minority groups.

Legal scholars and professionals are confronted with a rapidly increasing volume of legal publications. Only part of these publications are relevant enough to be cited. This project aims to determine which documents that are, and whether alternative metrics are a reliable way to predict whether documents…

The potential of bioneedles to deliver influenza vaccines was investigated.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

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This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…

We consider the propagation of electrical signals through nerve fibres.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Lecture

PhD defence

Antoaneta Dimitrova, Professor Comparative Governance at Leiden University, Honorata Mazepus, Assistant professor at Leiden University and Dimiter Toshkov, Associate Professor at Leiden University, together with three other authors researched which aspects of state capacity might contribute to opening…

In science, it is of vital importance that multiple studies corroborate the same result. Researchers therefore need to know all the details of previous experiments in order to implement the procedures as exactly as possible. However, this is becoming a major problem in neuroscience, as animal studies…

Galikyan’s dissertation examines how the multidimensionality of learner­learner interaction data and the multifacetedness of learner-learner interaction itself impact the measurement of learner-learner interaction in digital learning environments.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Light obscuration (LO) is the current standard technique for subvisible particle analysis in the quality control of parenterally administered drugs, including therapeutic proteins.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Intensive public debates have erupted about integration of immigrants in Europe. The influx of refugees from the middle east during the summer and autumn of 2015, the increasing visibility of immigrants throughout European societies, but also the widely publicized occurrences on New Year’s eve in Cologne…

Multi-Angle Dynamic Light Scattering (MADLS) is a technique that is used to determine properties of particles in suspension. The measurements give the hydrodynamic size distribution of individual particles as well as particle clusters, and assists in the interpretation of the stability of the particles…

Development and validation of instruments that can measure different aspects of emotional competence in children with normal and atypical development, and in different cultures

PhD defence

On 29 January 2019, Robbert van Eijk defended his thesis 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. The doctoral research was supervised by Prof. dr. H.J. van den Herik.

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.