Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: Prof.dr. M. de Jong

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

My work focuses on a class of astronomical objects called protoplanetary disks.

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

In the CarbonCap project, consumption oriented technological options and policy measures are identified as an addition to the present EU and world climate policy.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Het onderzoeksprogramma Industrial Ecology heeft als doel de ecologische transformatie naar duurzaamheid te ondersteunen van maatschappij en milieu. Het onderzoeksonderwerp is Industriële Ecologie in zijn breedste definitie, waaronder de analyse van milieusystemen en de integratie van de sociale en…

Bij Data Science & Artificial Intelligence leer je hoe je functies van het brein, zoals denken, geheugen, leren en aandacht in modellen kunt gieten. Deze kennis kun je gebruiken om computers en systemen op vergelijkbare of betere manieren te laten functioneren.

De masteropleiding Statistics & Data Science is een tweejarige master waarbij een diep doorgronde introductie wordt gelegd aan de algemene filosofie en methodologie van statistische modellen, statistisch modelleren, data analyse en data science, met de voornaamste focus op toepassingen in levens- en…

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Wat is het verband tussen materie met zwakke en sterke gravitationele wisselwerkingen?

In de design fase werk je aan het onderzoeken van een slimme oplossing voor het probleem en het schrijven van een businessplan.

Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?

Rachel Schats is Assistant Professor in Human Osteoarchaeology in the Faculty of Archaeology, Leiden University.

Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…

Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…

Arts and Culture

Bio-farmaceuten kunnen vanaf nu modelcodes en datasets uit een databank opvragen om de dosering en het effect van nieuwe medicijnen beter te kunnen voorspellen.

Methodologie & Statistiek richt zich op de ontwikkeling, evaluatie en toepassing van modellen voor de analyse van psychologische onderzoeksgegevens.

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

Promotor: A.W. van der Vaart

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

Hoe bepaal je bij een kind de juiste dosering van een medicijn? Dat kan niet altijd op basis van lichaamsgewicht. Maar soms kan dat wèl, ontdekte farmacoloog Elke Krekels. Ze won hiermee de TOP-Publicatieprijs van de Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie. In de uitzending…

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

Latent variable modeling of students' solution strategies and performance

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.