Promotor: Prof.dr. S.F. Portegies Zwart

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Promotores: S.F. Portegies Zwart, E. M. Rossi

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

Promotor: K.H. Kuijken

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Promotor: Prof.dr. E. F. van Dishoeck

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Veel kinderen leren niet op een niveau dat aansluit bij hun potentieel om te leren. Diagnostiek in de leerlingbeleiding zou daarom inzicht moeten geven in hoe een kind begeleid kan worden in het verder ontwikkelen van zijn of haar sterke kanten terwijl het tegelijkertijd handvatten biedt voor het ondersteunen…

Promotor: W.Th.F. den Hollander

An assessment approach that tailors to children’s instructional needs

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Hoe beinvloed de structuur van één enkel gen de activiteit van genen die gevoelig zijn voor hormonen?

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Het artikel 'Flexible updating of dynamic knowledge structures' met bijdrage van Franziska Richter van Cognitieve Psychologie is uitgebracht door Nature.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Developing methodes to understand the evolution of patches in natural ecosystems

Science, Institute of Environmental Sciences (CML)

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotor: Prof.dr. G.J. Kroes

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Remus Dame

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Read more

De negende Network Europe Conference in Edinburgh werd in juni 2017 gehouden en was georganiseerd door het Europa Instituut in Zurich.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Het verzamelen en interpreteren van grote hoeveelheden data is niet meer weg te denken uit de maatschappij en de wetenschap. De Universiteit Leiden is een kennis- en expertisecentrum van data science dat de nadruk legt op interdisciplinaire samenwerking en innovatie.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Science, Institute of Environmental Sciences (CML)

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Astronomen willen het heelal begrijpen, van de Oerknal tot nu, en hoe dit verder zal gaan. In Leiden concentreren ze zich daarbij op twee vragen: 'Hoe ontstaan sterren en planeten? en 'Hoe ontstonden in het jonge heelal sterrenstelsels en zwarte gaten?' Een nieuwe generatie telescopen – net klaar of…

Promotor: Prof.dr. B.R. Katzy

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.