What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

Promotores: J.N. Kok, H.J. Hoogeboom

Identification and characterization of components of DNA repair pathways and their role in Agrobacterium T-DNA integration and repair of CRISPR/Cas induced DSBs.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.

Promotor: R.D. Gill, F. Taroni

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Leiden physicist Maarten Kruithof has discovered how our DNA is infallibly able to fold itself and to unfold again. In his dissertation he demonstrates how DNA is folded in a single long, very flexible spiral.

Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.

With textnets it is possible to visualize and analyze textual data in novel ways.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

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Supervisor: P.J.J. Hooykaas

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Theoretical physicist Helmut Schiessel receives an NWO Projectruimte grant of 390,000 euro. He will use this budget to hire a postdoc and a PhD student to continue his research on flexibility of double stranded DNA.

In an Advance Online Publication biophysicist John van Noort and others show using magnetic tweezers that DNA is folded in compliant helices of chromatin. This allows enzymes access to the DNA needed for gene expression. Van Noort's research group made the discovery in close partnership with researchers…

The Explainatory Data Analysis group develops algorithms and theory that enable domain experts to explain data by finding interpretable patterns and models.

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Obtaining imaging data is nowadays only the start of your project. Once the data has been acquired there are many things that still need to be done.

Schneider

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

The research of our group is centered around dynamical systems, functional analysis and their interplay.

In this publication, Prof. Tahir Abbas, Inés Bolaños Somoano, Joana Cook, Isabelle Frens, Graig R. Klein and Richard McNeil-Willson look into the manifesto that was linked to the Buffalo attack in order to better understand the broader context and specific factors that motivated the perpetrator.

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

The main methodological aspects of the use of stepwise LCA estimators under different circumstances.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

This handbook provides a resource for those already familiar with some kinds of micro-particles who wish to learn more about others, or for those just starting out in the study of microremains who wish to have a broad understanding about microscopic archaeology.

Lecture, LUCIS What's New?! Series

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

The volume is one-stop shopping for crisis studies and a number of closely related fields, providing a window onto the latest thinking in the field. The articles reflect cutting edge, state of the art scholarship and pose key questions for research and practical development.

Dutch researchers have developed a new tool to label DNA for studying chromosomes in live cells. The tool is non-invasive and can be applied in culture but also in living organisms, such as zebrafish embryos. The team published their findings in the journal Nucleic Acids Research.

The focus of the Multicriteria Optimization and Decision Analysis (MODA) group is to develop foundations of methods in multi-objective optimization.

The Dutch Public Prosecution Service (OM) and the Netherlands Forensic Institute (NFI) want to use private DNA databases in an effort to solve deadlocked murder cases. Bart Custers, Professor of Law & Data Science at eLaw, Center for Law and Digital Technologies, expects that this is permissible from…

Researching DNA material for genetic disorders using the most powerful apparatus. This is what GenomeScan, a company on the Leiden Bio Science Park, does. Master's student Konstantina Konstantinopoulou is doing an internship there. 'It's a world where developments happen really rapidly so it's a fantastic…

This thesis is based on five papers on several topics.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

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Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.

The Automated Design and Analysis of Algorithms (ADA) research group pursues the development of Artificial Intelligence techniques that complement, rather than replace, human intelligence.

The main purpose of DNAmarkerpoint is to better understand the ecology, evolution and biodiversity through the study of ancient- and modern DNA.