Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Promotor: A.P. IJzerman

Promotor: A.P. IJzerman

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

PhD Defence

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Science, Leiden Institute of Advanced Computer Science (LIACS)

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

Promovenda Gineke Wiggers heeft de 2e prijs gewonnen voor haar paper over User-Focused Ranking in Legal Information Retrieval in het PhD consortium van de 31e International Conference on Legal Knowledge and Information Systems (JURIX).

De jaarlijkse LION Image award gaat naar de foto van een 30 micrometer lang 3D-geprint bootje dat in oktober viraal ging, ingediend door Rachel Doherty van de groep van Daniela Kraft.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Volgens astrochemici komt het Cyclopropenyl-ion molecuul veel voor in het heelal, maar er kon niet gericht naar worden gezocht met telescopen. Na een decennialange zoektocht is het lichtspectrum in het laboratorium gemeten. Het molecuul is een tussenproduct van chemische reacties die een rol spelen…

PhD Defence

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: J. Schaye

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

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Historical migration studies have long focused primarily on the European and Atlantic worlds. In this programmatic and long term project, we aim to broaden the perspective to include the full migration experience of the non-Western world.

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

In this thesis, classes of strongly interacting quantum field theories, have been studied.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

PhD Defence

Promotor: Prof.dr. G.P. van Wezel

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…