Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.

Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

We aim to develop A. niger strains that produce more starch degrading enzymes even in the absence of starch.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

Can the pink-pigmented microbe Methylobacterium extorquens be genetically engineered to convert the sustainable raw material methanol into antibiotics?

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

A team of researchers at the Institute of Biology Leiden, in collaboration with scientists from Utrecht University, has discovered a novel approach to improve the production of antibiotics and enzymes in the soil bacteria Streptomycetes.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Hass

This research network aims to create a shared platform for debate and dialogue on the broader theme of cultural production and exchange across different area specializations and historical periods.

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

Central to the research of several cluster members are the social function and contexts of the production and consumption of medieval and early modern art, literature and media:

Promotor: Prof.dr. C.A.M.J.J. van den Hondel, Dr. ir. V. Meyer, Co-promotor: Dr. A.F.J. Ram

How citizens and professionals are the key to successful collaboration in the delivery of public services. How do individual characteristics of citizens and professionals influence citizen-professional collaboration in the co-production of public services?

European product safety law is one of the focal points of internal market legislation.

Here you can find products and research tools developed by the Navigation Lab Leiden

Electrolysis is a technique that can be used to convert CO2 into fuels and other useful products. To do this efficiently and on a large scale, however, we need to understand exactly how electrolysis works. Professor Marc Koper is an expert in this field.

How can we make the production of chlorine cheaper and more friendly for the environment?

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

Loneliness and social isolation have become a significant problem in contemporary Japan. The financial burden associated with an ageing population has severely constrained the ability of local authorities to address the problem. As a result, policymakers have sought cost‐effective methods of tackling…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

In this thesis we study products of linear error correcting codes.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Creating information portals for support of European environmental policy.

Factors affecting galanthamine production in Narcissus

The Hydrogen network brings together leading researchers from different disciplines and sectors with a combined expertise that maximises the chance of achieving scientific breakthroughs in production and storage of hydrogen, while guaranteeing the successful training of a new generation of scientists…

How does task context affect children’s word productions?

This year, microbiologist Arthur Ram will start new research on producing useful enzymes in bulk. Ram receives an NWO grant for this project that will find its applications in the industrial biotechnology and food industry.

Promotor: Prof.dr. M. Danhof

On the 10th of February, Qian Li succesfully defended her PhD-thesis and graduated. LUCL congratulates Qian on this great result.

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…

When to launch a next-generation product in a competitive market and how much capacity should be allocated to it

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

They can play a role in metabolic disorders and can break down tough plant fibers: β-glycosidases are enzymes that play many roles in nature. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean energy and to improve the treatment of patients with metabolic diseases.

Research practice, funding agencies and global science organizations suggest that research aimed at addressing sustainability challenges is most effective when ‘co-produced’ by academics and non-academics. Co-production promises to address the complex nature of contemporary sustainability challenges…

Development of an aggregated impact indicator to measure decoupling.

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…

The article 'Co-productive agility and four collaborative pathways to sustainability transformations' is published in Global Environmental Change and accessible via OpenAccess. Professor Anthropology of Sustainability and Livelihood Marja Spierenburg of the Institute of Cultural Anthropology and Development…

International trade plays a critical role in global food security, with global consumption having highly localized environmental impacts.

As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.