In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

This thesis describes the design, characterization and application of dextran based crosslinked network.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Promotor: Prof.dr. L.J. Slikkerveer

Onderzoeksvragen stellen en beantwoorden via samenwerking en open science.

Science, Leiden Academic Centre for Drug Research (LACDR)

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Lecture, This Week's Discoveries

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Yisheng Development gaat het nieuwe entreegebied van het Leiden Bio Science Park vorm geven. De Universiteit Leiden en de gemeente Leiden hebben gekozen voor de Amstelveense projectontwikkelaar, die een duurzaam ontwerp voor een levendige campus voorstelde. Het ontwerp combineert wonen, werken en le…

Science, Leiden Academic Centre for Drug Research (LACDR), Leiden Institute of Chemistry (LIC)

Internist- klinisch farmacoloog Teun van Gelder is per 1 december 2019 benoemd tot Leidse hoogleraar Drug Discovery & Development. Hij zal zich bezighouden met het ontwikkelen van geneesmiddelen binnen de academische wereld, ook wel Academic Pharma genoemd.

Lecture

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Van 19 t/m 21 september werd de derde jaarlijkse ‘Law and Development Research Network’-conferentie gehouden in het Museum Volkenkunde in Leiden.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Lecture, Studium Generale

Science, Leiden Academic Centre for Drug Research (LACDR)

Science, Leiden Academic Centre for Drug Research (LACDR)

Science, Leiden Academic Centre for Drug Research (LACDR)

Inaugural Lecture

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Lecture, Studium Generale

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

PhD Defence

Science, Leiden Academic Centre for Drug Research (LACDR)

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

PhD Defence

LIBC PUBLIEKSDAG 'DRUGS & THE BRAIN' (in Dutch)

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Science, Leiden Academic Centre for Drug Research (LACDR), LACDR PhD Portal

In zijn proefschrift beschrijft hij de ontwikkeling van het arbeidsrecht in Indonesië. De nadruk ligt op de modernisering van het arbeidsrecht in de periode na de val van het Soeharto-regime in 1998, de reformasi.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Science, Leiden Institute of Chemistry (LIC)