341 search results for “chronic disease” in the Public website

• Neuropsychiatric phenomena in Huntington's disease Event - 12 May 2016

  PhD Defence

• Coach en kookboek helpen mensen met een chronische nierziekte News - 17 January 2018

  Hoge bloeddruk, overgewicht en diabetes hebben effect op de nierfunctie. Medisch psycholoog Yvette Meuleman van de Universiteit Leiden ging in gesprek met patiënten en zorgverleners, en ontwierp een leefstijlprogramma dat oog heeft voor de kwaliteit van leven. Promotie op 18 januari 2018.

• Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications Research output

  Machine Learning is becoming a more and more substantial technology for industry.

• Modeling Vascular Diseases Using Human Induced Pluripotent Stem Cells Event - 9 September 2020

  PhD Defence

• The role of the interleukin 12 family in atherosclerosis Research output

  Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

• Carcinogenicity of insulin analogues Research output

  Promotor: Prof.dr. B. van de Water

• Wiskundig model helpt ontstaan van wervels en ribben te verklaren News - 23 March 2020

  Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.

• Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts Research output

  Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

• Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases Research output

  Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

• B cell modulation in atherosclerosis Research output

  Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

• Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods Research output

  The zebrafish is a promising vertebrate model organism in early drug discovery and development.

• Involvement of host and bacterial factors in Agrobacterium-mediated transformation Research output

  Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

• Chemical genetic approaches for target validation Research output

  Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

• Design and development of conformational inhibitors and activity-based probes for retaining glycosidases Research output

  Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

• Huisartsgeneeskunde: Leerstoel e-health toepassingen in disease management Event - 11 December 2015

• Detecting hidden variation in our genome Research project

  Novel algorithms to detect indels and structural variants from next- and third-generation sequencing data.

• Novel insights into blood markers and cardiovascular disease Event - 29 October 2020

  PhD Defence

• Endothelial WT1 and the epicardium in cardiac development and disease Event - 13 September 2017

  PhD Defence

• Efficacy, safety and novel targets in cardiovascular disease Event - 5 March 2020

  PhD Defence

• Chromatin modifiers in DNA repair and human disease Event - 1 November 2016

  PhD Defence

• spatial transcriptomics and neuroimaging data in neurodegenerative diseases Event - 3 December 2020

  PhD Defence

• Preclinical validation of putative targets in cardiovascular and metabolic disease Event - 15 November 2018

  PhD Defence

• Functional and structural neuroimaging in Huntington's disease Event - 5 December 2019

  PhD Defence

• Aortic Valve Disease: Novel Imaging Insights from Diagnosis to Therapy Event - 10 March 2016

• Glycoproteomic characterization of immunoglobulins in health and disease Event - 31 May 2017

  PhD Defence

• Cardiometabolic disease in South Asians: risk factors and therapeutic strategies Event - 13 January 2021

  PhD Defence

• Combatting metabolic disease. Ethnic aspects, mechanisms and novel treatment strategies Event - 15 November 2018

  PhD Defence

• Impact of Huntington's disease on working and driving Event - 8 May 2019

  PhD Defence

• Mesenchymal stromal cell therapy for Crohn’s disease Event - 15 March 2016

• Value-Based Health Care in Inflammatory Bowel Diseases Event - 15 March 2016

• Neuropsychiatric symptoms and immune system parameters in Huntington's Disease Event - 18 October 2018

  PhD Defence

• Artificial Intelligence and eHealth for Inflammatory Bowel Diseases Event - 10 December 2020

  PhD Defence

• BMP signaling in vascular and heterotopic bone diseases Event - 9 March 2016

  PhD Defence

• Enhanced monitoring and screening in pediatric coeliac disease Event - 27 June 2019

  PhD Defence

• Lipids as therapeutic targets for barrier repair in skin diseases Event - 15 January 2020

  PhD Defence

• Data-Driven Knowledge Discovery in Polycystic Kidney Disease Event - 30 March 2021

  PhD Defence

• ecurrent miscarriage and the subsequent risk of cardiovascular disease Event - 26 June 2018

  PhD Defence

• Nieuwe stoffen remmen ontsteking in het brein News - 7 January 2016

  Leidse chemisch biologen, onder leiding van dr. Mario van der Stelt, hebben stoffen ontdekt die ontstekingsprocessen in de hersenen kunnen verminderen. Daarmee is een eerste stap gezet in de ontwikkeling van potentiële geneesmiddelen voor de behandeling van hersenziekten zoals de ziekten van Alzheimer…

• Genetics and epigenetics of repeat derepression in human disease Event - 1 September 2016

  PhD Defence

• A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies Research output

  The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

• Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer Research output

  This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

• Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management Research output

  The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

• Unraveling temporal processes using probabilistic graphical models Research output

  Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

• Multimodality imaging in ischemic heart disease, from prevention to outcome Event - 9 April 2019

  PhD Defence

• Ocular inflammation in age-related eye diseases Event - 27 June 2019

  PhD Defence

• Optical coherence Tomography for Coronary Artery Disease: Analysis and Applications Event - 4 September 2018

  PhD Defence

• Consortium DDMoRE lanceert open-access databank News - 13 November 2014

  Bio-farmaceuten kunnen vanaf nu modelcodes en datasets uit een databank opvragen om de dosering en het effect van nieuwe medicijnen beter te kunnen voorspellen.

• Menière's disease: clinical aspects, diagnostic tests and interventions Event - 15 October 2020

  PhD Defence

• UITGESTELD |Menière's disease: clinical aspects, diagnostic tests and interventions Event - 9 April 2020

  PhD Defence

• Celtypes in kaart gebracht van foetale nier News - 22 February 2019

  Nierfalen is een serieus probleem omdat nieren zichzelf niet kunnen regenereren na ernstige beschadiging. Een mogelijke oplossing bestaat uit het kunstmatig laten groeien van gezond nierweefsel. Daarvoor moeten wetenschappers eerst de ontwikkeling begrijpen tijdens de allereerste fase, in de foetus.…