In order to achieve a more sustainable food system, the food industry has to come up with new, environmentally friendly products. One aspect is producing proteins for meat substitutes. Bachelor’s student Rose Vossen modified, grew and studied different yeast strains to see whether they can be used to…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)

Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)

We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

‘I am studying Life Science and Technology. In my end project, I designed new yeast strains with point mutations to improve the biomass yield. To obtain this, I used a CRISPR CAS9 strategy to change a gene in two strains of yeast. After this change I compared them in a growth study with the wildtype…

Plant researchers have been wrong for years about how plant growth and development are regulated, as Yao Xiao pointed out during his PhD project. They overlooked the role of a protein that turns out to be essential, just as it is in the development of animals and yeasts. In plants, it regulates the…

Promotor: Prof.dr. J. Memelink

The channel through which two cell components exchange material appears to form at the edge of their contact surface, and not in the middle. This was discovered by the Leiden physical chemists Jelger Risselada and Edgar Blokhuis together with researchers from the University of Lausanne in Switzerland.…

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Promotor: A.P. IJzerman

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Promotor: Prof.dr. M. Ubbink

This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.

PhD defence

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

The Basics and Applications to Plant Sciences will be held physical. See below for more information.

The Green algae Chara as model system for intra and inter cellular transport processes.

The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.

Leiden theoretical physicists have proven that not only the genetic information in DNA determines who we are, but also DNA’s mechanics. Helmut Schiessel and his group simulated many DNA sequences and found a correlation between mechanical cues and the way DNA is folded. Publication in PLoS One.

A novel in vivo model system for studies on glucocorticoid resistance

Science, Institute of Biology Leiden (IBL)

Theoretical physicist Helmut Schiessel receives an NWO Projectruimte grant of 390,000 euro. He will use this budget to hire a postdoc and a PhD student to continue his research on flexibility of double stranded DNA.

A Leiden Groningen student team has reached the European finals of the BISC-E competition. In this annual competition students have to come up with a sustainable solution to a major social problem. The team invented Suckerspheres: a natural alternative to the plastic microbeads that are still widely…

Leiden biologists have shown that a gene present in plants, animals and yeasts does play an important role in plants, although for years the gene was considered unimportant. It turns out the gene plays a crucial role in the development of vascular tissue in plants. Publication in Nature Plants on 11…

A team of students from Leiden University, TU Delft and Rotterdam University won a golden medal during the International Genetically Engineered Machine competition (iGEM) in November in Boston. Their project ELECTRACE concerned a bacterium that can be used to search for landmines.

Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.

Rose Vossen has been named winner of the Young Star Award 2021. The Life Science and Technology student received the award on Monday from Ewine van Dishoeck, the founder of the award. Vossen wins a cheque for 2,500 euros for her exceptional results as a bachelor's student. During her final bachelor…

PoreLab is officially opened on November 1st, 2016. This new lab located at the Sylvius Laboratory will be working with the latest DNA analysis technology and will bring science, education and industry together to explore practical applications with the MinION.

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A team of students from Leiden and Groningen took the second prize at the European final of the BISC-E sustainability competition. Last June, the team had already won the Dutch finals. The students came up with ‘Suckerspheres’, a natural alternative to the plastic micro-particles that are still frequently…

Three projects with Leiden researchers are to receive a subsidy from NWO for the construction or renovation of large-scale research facilities. They will be working on electron microscopy, an X-omics initiative and an X-ray telescope. The projects are part of the National Roadmap for Large-Scale Scientific…

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Below thesis archives will be moved shortly (work in progress) to the Leiden Repository. Once this is done, theses submitted by MI students (from 2008 onwards) can be accessed via the Repository and will be removed from this site.