986 search results for “weak coupling limit” in the Public website
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Weak coupling between magnetically inequivalent spins: the deceptively simple, complicated spectrum of a 13C-labeled trimethyl amine
A deceptively simple, complicated paper
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Unveiling dark structures with accurate weak lensing
Improvements of weak gravitational lensing shape measurements are presented and some used for data analysis.
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Duality, bosonic particle systems and some exactly solvable models of non-equilibrium
Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander
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Dynamical Gibbs-non-Gibbs transitions: a study via coupling and large deviations
Promotores: F.H.J. Redig, W.T.F. den Hollander
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Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Unravelling molecular mechanisms in transcription-coupled nucleotide excision repair
PhD Defence
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Proteochemometric modelling coupled to in silico target prediction
An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Studying dark matter using weak gravitational lensing : from galaxies to the cosmic web
Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).
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diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
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Indanes-Properties, Preparation, and Presence in Ligands for G Protein Coupled Receptors
The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.
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Covalent inhibitors of G protein-coupled receptors: the case of adenosine receptors
Supervisor: Xue Yang
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Better ligands for G Protein-Coupled Receptors
The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.
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Limits of Tax Jurisdiction
How do tax treaties have to be explained and implemented, and what role does the supranational regulatory process play in this? Which objectives are meant to be used in establishing tax regulations and to what extent are such legislative practices undertaken in a goal-oriented manner?.
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6)F motif and helix 8 of the adenosine A(2B) receptor in G protein coupling
Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)
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Immunotherapy to limit atherosclerosis-projects
For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Bayesian learning: challenges, limitations and pragmatics
This dissertation is about Bayesian learning from data. How can humans and computers learn from data?
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Islam and the Limits of the State
Reconfigurations of Practice, Community and Authority in Contemporary Aceh
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Legislative Policy in Brazil: limits and possibilities
‘It became very clear that Brazilian legislative policy was frail, obsolete and unreliable,’ says Felipe de Paula. He defended his dissertation on the limits and possibilities of legislative policy in Brazil on Tuesday 27 March 2018.
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Scaling Limits in Algebra, Geometry, and Probability
PhD Defence
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space smarter: Artificial intelligence in drug design for G protein-coupled receptors
PhD Defence
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Methods to simulate fermions on quantum computers with hardware limitations
This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.
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Deep learning for tomographic reconstruction with limited data
PhD Defence
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EU Executive Discretion and the Limits of Law
The increase in the European Union's executive powers in the areas of economic and financial governance has thrown into sharp relief the challenges of EU law in constituting, framing, and constraining the decision-making processes and political choices that have hitherto supported European integration.…
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Marc Stevens and colleagues reveal weak spot in internet security
Marc Stevens, PhD student of Ronald Cramer, and colleagues have found a weak spot in internet security. As a consequence of this weak spot in the infrastructure of digital certificates forged certificates can be issued that can be fully trusted by the usual web browsers. The results have been presented…
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The Limits of Europe: Membership Norms and the Contestation of Regional Integration
Where does Europe begin and end? How have the European Union and its precursors decided which countries are eligible to join the community and which are not? Few issues are more hotly debated, more important for the course of European integration, or more consequential for individuals in and around…
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A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunits
Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)
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Wim Voermans in Nieuwsuur on weak legal basis of curfew
The decision by the court in preliminary relief proceedings to immediately lift the curfew in the Netherlands – following a case brought by pressure group Viruswaarheid (Virus Truth) – has been overturned until the appeal on the case is heard this Friday. The government is doing everything in its power…
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The limits of tolerance: before and after Brexit and the German Refugee Crisis
This study investigates how two social and political developments, in the UK and Germany, impacted on the experiences of minorities and the attitudes of majorities vis-à-vis tolerance in those two countries. The results provide a thought-provoking picture of the views of minority and majority groups…
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Donner warns against a weak European Union
The refugee crisis and terror threats call for better European cooperation, was the message from Piet Hein Donner in his Cleveringa lecture on 26 November in the Academy Building. ‘Opting for an open and pluriform community takes courage.’
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Causal Discovery from High-Dimensional Data in the Large-Sample Limit
Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets
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aftermath of acute pulmonary embolism: approach to persistent functional limitations
PhD Defence
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State visit of the Dutch Royal couple to Luxembourg
On Thursday 24 May 2018, Tanja Masson-Zwaan of Leiden University’s International Institute of Air and Space Law and Prof Mahulena Hofmann of the University of Luxembourg had the honour of addressing the King and Queen of the Netherlands and the Grand-Duc and Grand-Duchess of Luxembourg during the State…
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Space Description Methods for Analysing Combustion Engine Operation Limits
Promotor: Prof.dr. T.H.W. Bäck
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Investigating the possibilities and limitations of Process-oriented Dynamic Testing.
Can process-oriented dynamic testing be applied to everyday educational practice?
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A Literary History of Reconciliation. Power, Remorse and the Limits of Forgiveness
From William Shakespeare to Marilynne Robinson, A Literary History of Reconciliation is the first study to examine representations of interpersonal reconciliation in work of literature across a long-term period, from the early seventeenth century to the present day, focusing on how these representations…
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Voluntary return and the limits of individual responsibility in the EU Returns Directive
PhD Defence
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Magnetism and magnetization dynamics in thin film ferromagnets
Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek
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Search for mechanisms to control massless electrons in graphene
Beenakker
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Same-sex couples in Europe: more rights in more countries
The trend of legal recognition for gay and lesbian couples is broadening. More and more rights are becoming available to same-sex partners – in more and more European countries. Leiden Law School and the French Institute for Demographic Studies publish detailed database and comparative analysis.
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The limits of open government
The Ministry of Health, Welfare and Sport in the Netherlands is being flooded with applications for information under the Dutch Public Access to Government Information Act (WOB) and according to Minister Hugo de Jonge is unable to provide the information on time. News programme Nieuwsuur has been waiting…
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Limiting Viral Spread: Automated Cyber Operations and the Principles of Distinction and Discrimination in the Grey Zone
Monica Kaminska, Dennis Broeders and Fabio Cristiano have contributed a chapter to the proceedings of the 13th International Conference on Cyber Conflict (CyCon 2021), which gathers 20 articles from the law, technology and strategy domains.
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Space Law during the State visit of the Dutch Royal couple to Luxembourg
On Thursday 24 May 2018, Tanja Masson-Zwaan of Leiden University’s International Institute of Air and Space Law and Prof Mahulena Hofmann of the University of Luxembourg had the honour of addressing the King and Queen of the Netherlands and the Grand-Duc and Grand-Duchess of Luxembourg during the State…
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The galaxy–dark matter connection: a KiDS study
In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.
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Adriaan IJzermanScience