A deceptively simple, complicated paper

Improvements of weak gravitational lensing shape measurements are presented and some used for data analysis.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Promotores: F.H.J. Redig, W.T.F. den Hollander

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

Central Limit Theorem associated to a particular case of ergodic total automorphisms. Finally, Chapter 6 proves that the isoperiodic foliation is connected for a meromorphic differential with three poles on a torus.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

VVI Research Meetings 2022-2023

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.

Supervisor: Xue Yang

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

How do tax treaties have to be explained and implemented, and what role does the supranational regulatory process play in this? Which objectives are meant to be used in establishing tax regulations and to what extent are such legislative practices undertaken in a goal-oriented manner?.

Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

Promotor: A.P. IJzerman

Promotor: A.P. IJzerman

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Promotor: A.P. IJzerman

Reconfigurations of Practice, Community and Authority in Contemporary Aceh

‘It became very clear that Brazilian legislative policy was frail, obsolete and unreliable,’ says Felipe de Paula. He defended his dissertation on the limits and possibilities of legislative policy in Brazil on Tuesday 27 March 2018.

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

The increase in the European Union's executive powers in the areas of economic and financial governance has thrown into sharp relief the challenges of EU law in constituting, framing, and constraining the decision-making processes and political choices that have hitherto supported European integration.…

Marc Stevens, PhD student of Ronald Cramer, and colleagues have found a weak spot in internet security. As a consequence of this weak spot in the infrastructure of digital certificates forged certificates can be issued that can be fully trusted by the usual web browsers. The results have been presented…

On 10 February 2022, Christian Mommers defended the thesis 'Voluntary return and the limits of individual responsibility in the EU Returns Directive'. The doctoral research was supervised by Prof. P.R. Rodrigues and Prof. P. Boeles.

Where does Europe begin and end? How have the European Union and its precursors decided which countries are eligible to join the community and which are not? Few issues are more hotly debated, more important for the course of European integration, or more consequential for individuals in and around…

The decision by the court in preliminary relief proceedings to immediately lift the curfew in the Netherlands – following a case brought by pressure group Viruswaarheid (Virus Truth) – has been overturned until the appeal on the case is heard this Friday. The government is doing everything in its power…

Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)

The refugee crisis and terror threats call for better European cooperation, was the message from Piet Hein Donner in his Cleveringa lecture on 26 November in the Academy Building. ‘Opting for an open and pluriform community takes courage.’

This study investigates how two social and political developments, in the UK and Germany, impacted on the experiences of minorities and the attitudes of majorities vis-à-vis tolerance in those two countries. The results provide a thought-provoking picture of the views of minority and majority groups…

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

On Thursday 24 May 2018, Tanja Masson-Zwaan of Leiden University’s International Institute of Air and Space Law and Prof Mahulena Hofmann of the University of Luxembourg had the honour of addressing the King and Queen of the Netherlands and the Grand-Duc and Grand-Duchess of Luxembourg during the State…

Promotor: Prof.dr. T.H.W. Bäck

Can process-oriented dynamic testing be applied to everyday educational practice?

From William Shakespeare to Marilynne Robinson, A Literary History of Reconciliation is the first study to examine representations of interpersonal reconciliation in work of literature across a long-term period, from the early seventeenth century to the present day, focusing on how these representations…

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Beenakker

The making of sacrifices seems part and parcel of any elite sportsperson’s life. Remarkably, the insights that we find in the current literature in social sport studies are not able to make sense of the references to sacrifice in the data that emerged in the context of this study on the social significance…

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.