With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

How can we culture an artificial vascular network to support tissue development ex vivo?

The Faculty of Medicine

Getting personal

Assessing and implementing new diagnostics strategies for stratifying patients

Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?

Leiden University offers a unique interdisciplinary joint-degree Master programme in technical medicine together with TU Delft, Erasmus University Rotterdam and their academic medical centers.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

The mission in this research group, headed by Ad IJzerman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

Promotor: Prof.dr. R.M.H. Merks

Collecting as much information as possible about administering a new medicine to people can save a lot of money.

We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

This Master programme will equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. Its current concept includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy and immunotherapy. Areas that are integrated…

Science, Leiden Academic Centre for Drug Research (LACDR)

Can drug screening for tuberculosis treatment be made more efficient?

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…

Sonja Boas developed new techniques to study vascular growth computationally. The results of her research provide a better understanding into mechanisms behind vascular growth, which is relevant to the development of medical therapies. She defends her thesis 'Computational modeling of angiogenesis'…

Fascinated by science since high school, Alireza Mashaghi Tabari is driven to explore new ways of thinking in medicine. With a strong academic network, he educates students and gives public lectures. For his research at LACDR, he won the C.J. Kok Public Award 2018, making him the Faculty of Science's…

Promotor: Prof.dr. E.F. Smets, Co-promotor: T.R. van Andel

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

Science

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

Can the pink-pigmented microbe Methylobacterium extorquens be genetically engineered to convert the sustainable raw material methanol into antibiotics?

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

Miranda van Eck is benoemd tot hoogleraar Cardio Vascular & Metabolomic Therapeutics bij het Leiden Academic Center for Drug Research (LACDR) van de faculteit der Wiskunde en Natuurwetenschappen. De benoeming ging per per 1 februari 2014 in.

Source: J Cheminform, Volume 6, Issue 1 (2014)

An investigation into how racial stereotypes were created and used in the European Middle Ages.

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.

The collaboration between Leiden University (Medical Center) and the Autonomous University of Barcelona forms one of the most powerful international alliances for the creation and transmission of knowledge in the field of transfusion medicine.

Conference