PhD defence

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…

Key publications of the Skin Barrier and Vaccination group.

Chiodo

Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.

Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Political Scientist Gisela Hirschmann (Leiden University) asks how international organisations can be compelled to comply with respect human rights. She finds that this is done through ‘pluralist accountability’: external third parties such as courts, NGOs, or regional organisations holding international…

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

This paper examines the need and possibility for developing online resilience-based approaches in response to COVID-19 vaccine conspiracies, often linked to the far right.

Researchers Indu Khatri, Frank Staal and Jacques van Dongen from Leiden University Medical Center (LUMC) have published a perspective article in Frontiers in Immunology about coronavirus and its characteristic ‘spike protein.’ They predict which antibodies would provide the best protection against the…

PhD defence

PhD defence

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

Lecture, Lunch Research Seminar

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

From a new generation of antibiotics and more-effective vaccines to a map of dark matter and new light on Hindu traditions. Four researchers from Leiden University have received a prestigious €2.5m ERC Advanced Grant to develop their research.

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

PhD defence

PhD defence

PhD defence

The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.

Formulation of biopharmaceuticals

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

Current research at the Skin Barrier and Vaccination group.

Research at the BIOSYN group is comprised of the following research themes:

A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…

It’s all hands on deck at the moment to resolve the COVID-19 crisis. Researchers from various disciplines are helping where they can, also from the field of artificial intelligence (AI). AI offers great opportunities both at the frontline of the crisis and in its expected aftermath. Leiden professor…

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

How are carbohydrates processed by the immune system? Can carbohydrates be used to trigger T-cells against other conjugated antigens? Can they be used as adjuvants?

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Coronavirus: information for students, staff and visitors.

The Gymclub is a sub-group of ProParte.

The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…