The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

How distance-dependent is graphene as biological sensor?

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

We study the physics of a broad range of biological and soft materials

Schneider

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

How do nanoparticles bioaccumulate and biodistribute in organisms?

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Direct radiocarbon dating of human remains is crucial for the accurate interpretation of prehistory. Yet given the scarcity of prehistoric human remains, direct dating is often too destructive for important fossils. The reduction of sample size necessary for dating bone is therefore of great interest…

The Physics and Biological and Soft Matter master's specialisation is one of the two programmes that Leiden University offers in experimental physics. This programme mainly focuses on Biological Physics and Soft Matters Physics.

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Are there acoustic cues for settlement stage larvae in deep-sea soundscapes around hydrothermal vents?

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Light obscuration (LO) is the current standard technique for subvisible particle analysis in the quality control of parenterally administered drugs, including therapeutic proteins.

Promotores: H. Schiessel, G.T. Barkema

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

This handbook provides a resource for those already familiar with some kinds of micro-particles who wish to learn more about others, or for those just starting out in the study of microremains who wish to have a broad understanding about microscopic archaeology.

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

This year's Nobel Prize for Medicine goes to the three American researchers who have unravelled the mechanism behind the biological clock. Joke Meijer, Professor of Neurophysiology and an expert in the field of the sleep-wake rhythm, explained in Dutch newspapers Trouw and NRC why this discovery is…

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

What is vegetation structure and composition in SFM primary forest, secondary logged over forest (logging FSC certified and logging non certified) in comparison to primary forest? What is avian guild diversity in SFM primary forest, secondary logged over forest (logging FSC certified and logging non…

Description of The Regional Network on the Synergy between the Convention on Biological Diversity and the UN Convention to Combat Desertification.

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Researchers at LUMC are trying to decipher the biological clock. This knowledge can help deal with luxury problems, such as jetlag, but can also counter diseases. Molecular neurobiologist Erno Vreugdenhil explains.

A couple of years ago, Dr Amanda Henry noted that she was unable to determine all microremains in her archaeological samples. Herself an expert on starches, she had trouble recognising other microparticles. Seeing the importance of interdisciplinarity, she organised a conference on microremains. This…

Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.

On Friday the 6th of December, the annual symposium of the IBL was organized at the Buruma theatre (LUMC), Leiden. This year’s theme was “Biological Networks from Molecules to Society”.

The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…

During Seeing Stars Leiden all the lights around Leiden Observatory will be switched off for an hour. The more lights that go out, the more stars we’ll be able to see. For the LUMC, this is the perfect moment to think about our biological clock, the topic researchers from the BioClock consortium are…

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

The LUMC Flow Cytometry Core Facility accommodates all research and diagnostic flow cytometry equipment of the LUMC.

Which metabolites of sponge are influenced by individual environmental or biological factors?

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

Using biologically inspired algorithms on 'edge devices', such as cameras and mobile phones, is what Svetlana Minakova's PhD research was all about. She conducted research on Convolutional Neural Networks(CNN). Making these algorithms work in different situations is a complicated task. 'Most design…

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

In August-September 2016 three CML students are doing an exciting field work in sub-arctic tundra in Sweden in collaboration with Ümea University.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Patterns of paleomobility in the Caribbean were studied through an inter-disciplinary approach using a combination of archaeological, osteological, mortuary, and isotopic data.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…