Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

This thesis reports on a study that examined the development of L1 teachers’ practical knowledge when they researched and implemented concept-context rich education in an action-research setting.

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

In his thesis Tjandra analuses the development of labour law in Indonesia. He focusses on the developments after the fall of the Soeharto regime (1998), the so called reformasi period.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

Do you want to know more about Cultural Anthropology and Development Sociology and what it is like to study in Leiden? Come to our online or on campus information events.

In this project, the hypothesis that language contact crucially impacts the development of spatial grammar and phonology is investigated.

This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…

My ERC Starting Grant, funded with €1.5 million for 5 years as part of the Horizon 2020 research and innovation program, is focused on building the early warning system WARN-D to reliably forecast depression in young adults before it occurs. Why depression, and why prediction?

To maximise your personal development, we ensure tutorials are small-scale and staff members extremely accessible. In year one, you’ll have an average of 12 contact hours, half of which comprise lectures (in English) and the remainder tutorials (optionally Dutch or English).

Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.

We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

The research addresses the question of “what is the impact of geopolitical changes to the pivot states in the Middle East? With special focus on Turkey, Iran and Saudi Arabia.”

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

On 26 June 2019, Lisa Louwerse defended her thesis 'The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement'. The doctoral research was supervised by Prof. C.A.P. Hillion.

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

On October 31st, Margarita Gulian succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Margarita on this great result.

In this project, the hypothesis that language contact crucially impacts the development of spatial grammar and phonology is investigated.

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Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

How can we explain that Caribbean small states have the most stable two-party systems in the world, while Pacific small states have either very weak parties or no parties at all? Matthew Louis Bishop (University of Sheffield, UK), Jack Corbett (University of Southampton, UK) and Wouter Veenendaal (Leiden…

Promotor: Prof.dr. R.M.H. Merks

Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…

Developing new drugs is a difficult process. With the aid of artificial intelligence, Pharmaceutical scientist Xuhan Liu has developed methods that can help make drug design cheaper and faster. PhD defence on 15 February.

Cell biologist Erik Danen has been awarderd a grant of half a million euros to study how tumor cells spread throughout the body en develop drug resistance. This was announced mid-August by the Dutch Cancer Society Fund (KWF).

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PhD Defence

PhD Defence

Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…

Do natural soundscapes affect migratory decisions of fishes moving up and down rivers and is this process disturbed by vessel sounds?

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Key publications of the Cancer Drug Target Discovery group

Source: Mediators Inflamm (2014)

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

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Medicines are becoming increasingly precise and innovative, but at the same time increasingly expensive. With their innovations, it is up to universities to increase competition, thus causing prices to drop. This is what newly appointed Professor of Biomolecular Analysis Hubertus Irth argues. His inaugural…

PhD Defence

Presenting case studies by both senior and emerging scholars, it makes mandatory reading for anyone interested in the challenges of governance, citizenship and development faced by the people of India’s North East.

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The Leiden Institute of Physics has been awarded three out of twelve available grants from the FOM Projectruimte. Principal Investigators Milan Allan, Stefan Semrau and Carlo Beenakker all receive around 400,000 euro for their research.