47 search results for “transcriptomics” in the Public website
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Bing Xie
Science
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Esmee Koedoot
Science
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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Integrated omics approaches for systems understanding of adverse outcome pathways
Pathways of toxicity
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The role of the Arabidopsis AHL15/REJUVENATOR gene in developmental phase transitions
This thesis describes the functional analysis of the Arabidopsis AHL15 gene.
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Analyzing spatial transcriptomics and neuroimaging data in neurodegenerative diseases
PhD Defence
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Bioinformatics and Genomics
The Bioinformatics and Genomics Core provides bioinformatics advice and genotyping services. The researchers that lead and work for this facilities are experts in their fields and are available for consultation regarding experimental design and interpretation of results.
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Strategy
The division of Systems Biomedicine and Pharmacology focusses on personalised medicine and the development of novel systems-based approaches in translational and clinical pharmacology.
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Stefan Semrau Lab (Quantitative Single-Cell Biology)
We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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microenvironment in colorectal cancer: an integrative histopathological, transcriptomic and metabolomic approach
PhD Defence
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The use of transcriptomics data in detecting non-genotoxic carcinogens
PhD Defence
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Vaccine delivery
Vaccination via the skin or the mucosae
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Bioactive Molecules in Animal Sciences
Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen
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CAM-PaC
The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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The Ecology and Evolution of Microbial Warfare in Streptomyces
The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.
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Cancer Therapeutics and Drug Safety
In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…
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Cell architecture and pathways for parallel secretion in the filamentous fungus Aspergillus niger
Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Modeling interactions to unravel biomarkers for disease progression and treatment response
The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets
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Evolution and development of orchid flowers and fruits
To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.
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Drug safety Sciences
Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.
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Versatile SNP genotyping
The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…
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Regulation of vegetative development and life history strategy in plants
How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?
- Medicine / LUMC
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Glucocorticoid modulation of the immune response
Unraveling the immune-suppressive actions of drugs like prednisone.
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Galactofuranose biosynthesis in the filamentous fungus Aspergillus niger
This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.
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Cell Wall Dynamics in Aspergillus niger
This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.
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IBL symposium “Integrative Biology towards Healthy Communities”
On Monday the 8th of December, the annual symposium of the IBL will be organized at the main building of the LUMC Leiden. This year’s theme is “Integrative Biology towards Healthy Communities”.
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Research
An overview of the research at the Cancer Dug Target Discovery group.
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…
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Science
The Faculty of Science
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Vision and Mission
The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.
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PhD candidate - biology of induced pluripotent stem cells
Science, Leiden Academic Centre for Drug Research (LACDR)
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Opening PoreLab
PoreLab is officially opened on November 1st, 2016. This new lab located at the Sylvius Laboratory will be working with the latest DNA analysis technology and will bring science, education and industry together to explore practical applications with the MinION.
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Leiden scientists map cell types in fetal kidney
Kidney failure is a serious issue because kidneys cannot regenerate themselves after injury. A possible solution consists of artificially growing healthy kidney tissue. To achieve that, scientists first need to understand kidney development during the earliest stages, in the fetus. Leiden researchers…
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Researchers reveal how stem cells make decisions
Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…
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Robert Rissmann appointed professor of Translational Dermatology at LACDR-CHDR
Pharmacist-clinical pharmacologist Robert Rissmann has been appointed Professor of Translational Dermatology. This extraordinary professorship has been created jointly by the Leiden Academic Centre for Drug Research (LACDR) and the Centre for Human Drug Research (CHDR) to strengthen their partnership…
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Learning from Nature, learning from our Ancestors; from tradition to evidence based medicines
Conference
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Publications
Recent publications