Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Promotor: J.M. Memelink

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

As an Exchange or Study Abroad student you will receive an academic transcript from Leiden University which lists the courses you have passed, with grades and credits obtained.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Prospective employers sometimes request a certified copy of your diploma or your academic transcript. These certified copies can be provided by the University. You can also apply to the University for advice on having your diploma translated.

Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.

For questions about a English diploma statement and/or a transcript in English, you can contact your faculty or the administration of your study.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

What is the role of memory in contemporary music?

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.

Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.

Promotor: Prof.dr. J. Memelink

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Factors affecting galanthamine production in Narcissus

Since itch and pain can be very burdensome, especially when individuals suffer from (either of) these symptoms chronically, it is important to know the factors by which these sensations are influenced. It becomes more and more clear that psychological factors play an important role in the experience…

How can Staphylococcus aureus bacteria subvert the host immune system?

PhD Defence

Promotor: Prof.dr. J.P. Abrahams

How does FoxP1 affect auditory perception on a behavioural and genomic level?

PhD Defence

What is the function of the insect serosa?

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…

Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.

Visualization of biomolecules in living cells by tagging with gold nanoparticles.

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Why do certain incidents of serious violence end lethally whereas others do not? What role do personal characteristics of offenders and victims play and how do immediate situational factors influence outcomes?

The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Plant Sciences' contribution to the Evolution & Biodiversity research theme is to understand what are the key drivers of plant biodiversity during evolution with a focus on plant life history and resilience traits and develop tools to restore and maintain plant biodiversity.

How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?

How can zebrafish research help understanding human diseases?

In order to stop a whole range of diseases or disorders at their source, you would have to be able to switch certain genes on or off. Sebastian Pomplun wants to develop substances that can do this very precisely. For example, he wants to disrupt cancer processes and make cells produce an important missing…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.

What is the role of auxin in the initiation and process of somatic embryogenesis?

Broader and more-transparent metrics could help improve how academic quality is assessed. This is what Centre for Science and Technology Studies (CWTS) researchers Paul Wouters (also Dean of the Faculty of Social Sciences), Sarah de Rijcke and Ludo Waltman write together with colleagues in a comment…

Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…