Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Inaugural lecture

School of pharmaceutical sciences, University of Geneva - Switzerland

Contact

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.

Promotor: B. van de Water

How do nanoparticles bioaccumulate and biodistribute in organisms?

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

Engineered nanomaterials (ENMs) are widely used, and nanotechnological innovations grow with rapid pace. Studies on nanotoxicology have demonstrated that chemical toxicology as well as particle toxicology should be accounted for in predicting the safety of ENMs.

An international research consortium led by Bob van de Water, Professor of Toxicology at Leiden University, has been awarded a prestigious Horizon2020 grant of 30 million euros.

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…

Promotor: Prof.dr. M.K. Richardson

The division of Drug Discovery and Safety combines the former divisions Toxicology and Medicinal Chemistry.

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We are moreover strongly involved in the Master specialisation of Pharmacy at Leiden University. We work on clinical problems that require further mechanistic understanding and…

We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.

The master’s specialisation Industrial Pharmacy at Leiden University examines safety and quality control in the production of medicinal products, and prepares students for a career in Quality Assurance and Quality Control in the biotechnological and pharmaceutical industry.

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

The master’s specialisation Bio-Pharmaceutical Sciences and Education at Leiden University combines fundamental chemistry research with an excellent education in becoming a Chemistry teacher.

The master’s specialisation Bio-Pharmaceutical Sciences and Business Studies at Leiden University combines fundamental and applied research with different aspects of business studies.

The master’s programme of Bio-Pharmaceutical Sciences at Leiden University examines the research area of bio-pharmaceutical sciences and drug research. It offers seven specialisations ranging from BioTherapeutics to Industrial Pharmacy.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

The master’s specialisation Bio-Pharmaceutical Sciences and Science Communication & Society at Leiden University is a two-year programme which combines research training in chemistry with one in techniques of communication.

Ad IJzerman was elected Highly Cited Researcher in the 2019 Web of Science mapping of research achievements. As defined by the Web of Science team at Thomson Reuters “highly cited researchers are among those who have demonstrated significant and broad influence reflected in their publication of multiple…

Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

How can zebrafish research help to understand and fight human cancer?

Key publications of the Quantitative Clinical Pharmacology group

Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.

Key publications of the Quantitative Pharmacology group

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

Recent publications

The list of highly Cited Researchers identifies the world’s most influential contemporary researchers across 21 scientific fields. Prof. dr. W. Jiskoot is cited one out of three in the field of Pharmacology & Toxicology in the Netherlands, and as one of four of all categories in Leiden.

Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…

From the Republic of Moldova to Italy and from Indonesia to Greece, students from all over the world participated in the Bio-Pharmaceutical Science Summer School 2017. The students got a comprehensive overview of the education and research performed within the LACDR. ‘I am very happy to be here,’ says…