In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Science, Leiden Institute of Chemistry (LIC)

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Project TARGET aims to improve our understanding of gun violence in Europe and the relationship between gun violence and firearms trafficking.

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Is is possible to better predict the validity of drug candidates?

In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?

Source: ChemMedChem (2015)

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

PhD Defence

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Supervisor: Anna Vlachodimou

Novel methods for understanding key aspects that are essential to the future of Bayesian inference for high- or infinite-dimensional models and data.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The division of Drug Discovery and Safety combines the former divisions Toxicology and Medicinal Chemistry.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Science, Institute of Biology Leiden (IBL)

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

During the course of drug discovery translational steps are made.

Supervisor: Andrea Martella

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

Our previous meta-analysis (Swart et al., 2019) had shown that feedback targeting text comprehension given when students perform a reading task positively influences learning from text. So far, differences in the effects of feedback were explained by design features, such as the timing and richness…

Miranda van Eck is benoemd tot hoogleraar Cardio Vascular & Metabolomic Therapeutics bij het Leiden Academic Center for Drug Research (LACDR) van de faculteit der Wiskunde en Natuurwetenschappen. De benoeming ging per per 1 februari 2014 in.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

A therapeutic vaccine against HPV-16 (type 16 human papillomavirus) improves the survival rate in cervical cancer patients. A new study by ISA Pharmaceuticals B.V. (a Leiden-based biotechnology company) and the Leiden University Medical Center (LUMC) shows that this vaccine produces a more robust response…

Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield

Science, Leiden Institute of Chemistry (LIC)

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Science, Leiden Institute of Chemistry (LIC)

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Has the industrial sector in China effectively been decarbonizing in recent years, across different regions and subsectors, and is it plausible that it will reduce its CO2 emissions in conformity with national and internationally pledged emission goals?

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…

On Thursday 26 January 2017 Anouk Bosma will defend her doctoral thesis ‘Targeting recidivism: An evaluation study into the functioning and effectiveness of a prison-based treatment program’. The defence will start at 15.00 hrs, at the Academy Building of Leiden University, Rapenburg 73. Supervisor…