2,166 search results for “targeted therapy” in the Public website
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Postdoc – iPSC technology to discover targeted therapy for Nrf2 antioxidant response modulation.
Science, Leiden Academic Centre for Drug Research (LACDR)
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Targeting for success: Mechanistic insights into microRNA-based gene therapy for Huntington disease
PhD defence
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Cell Therapy
Decision support tool for cell therapy commercialization and business development
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Cancer Pathogenesis and Therapy
Cancer represents a formidable current and future global health challenge. The LUMC medical research profile Cancer Pathogenesis and Therapy charges this challenge by developing and implementing innovative patient-tailored, multimodal diagnostic methods and treatment modalities.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
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OPENup: Optimizing exposure therapy for Posttraumatic Stress disorder
Although exposure therapy is the gold-standard treatment of posttraumatic stress-disorder (PTSD), only half of the patients adequately benefit from it. Based on recent insights into the mechanisms of extinction, this project examines strategies and techniques to improve exposure treatment outcome in…
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Transfusion Medicine and Cellular and Tissue Therapies
This joint Master programme will equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. Its current concept includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy and immunotherapy. Areas that are integrated…
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Transfusion Medicine and Cellular and Tissue Therapies
Are you thinking about studying Transfusion Medicine and Cellular and Tissue Therapies? Learn more and watch our video of our live-presentation we held at the Online Master's Open day.
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Antibiotic combination therapies against drug resistant Gram negative pathogens
Can effective synergists be identified to enhance the effect of antibiotics against Gram negative pathogens?
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Agrobacterium-mediated protein therapy for genome editing
Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?
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Pursuing new anti-cancer therapy as a team
Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…
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Epilepsy and anxiety: targeting a vicious cycle
How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?
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UM Cure 2020: New therapies for uveal melanoma
Can we bring novel treatment options to the clinic for UM patients with liver metastases?
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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Assistant Professor – bioinformatics in advanced therapy medicinal products
Science, Leiden Academic Centre for Drug Research (LACDR)
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From islet transplants to stem cell therapy for diabetes patients
Stem cells can be differentiated into insulin-producing cells.
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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Clinical aspects of immunotherapy and targeted therapy of advanced melanoma
PhD defence
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Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
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Targeted Therapy for Triple-Negative Breast Cancer
PhD defence
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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Using zebrafish to target the Achilles’ heel of cancer
Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.
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Intervention targets in cognitive development
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Adjudicating Attacks Targeting Culture
On 27 May 2021, Hirad Abtahi defended his thesis 'Adjudicating Attacks Targeting Culture'. The doctoral research was supervised by Prof.dr. C. Stahn.
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Metabolomic fingerprint biomarkers to guide antibiotic therapy and reduce resistance development
Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…
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Efficient gene-targeting during meiosis
Efficient gene-targeting during meiosis
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2 PhD candidates in Bioinformatics Stem Cells-Based Therapies Development
Science, Leiden Academic Centre for Drug Research (LACDR)
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Proteochemometric modelling coupled to in silico target prediction
An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.
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PhD candidate in Bioinformatics Safety Assessment of Gene and Cell Therapy
Science, Leiden Institute of Chemistry (LIC)
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.
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Master’s Experience: Master Transfusion Medicine and Cellular and Tissue Therapies
Study information
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Discovery of metastasis promoting candidate drug targets
Discovery of metastasis promoting candidate drug targets
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Targeted biomolecule production for therapeutic use
We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.
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PhD candidate for the project “Targeting immunosenescence in atherosclerosis”
Science, Leiden Academic Centre for Drug Research (LACDR)
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Drug-target binding kinetics in vivo
A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.
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Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
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Inhibitors and probes targeting endo-glycosidases
The chemical synthesis of inhibitors and probes targeting endo-glycosidases.
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Is a cancer pill a matter of time?
A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Targeting gun violence & trafficking in Europe
To assess the impact of illicit firearms trafficking on gun violence, this research looks at the scope, characteristics and contexts of firearm violence, and also the scope and nature of firearms trafficking in Europe since the new millennium. Nils Duquet, Dennis Vanden Auweele and Marieke Liem created…
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Personalized treatment for von Willebrand disease by RNA-targeted therapies
PhD defence
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Personalized treatment for von Willebrand disease by RNA-targeted therapies
PhD defence