We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

The division of Drug Discovery and Safety combines the former divisions Toxicology and Medicinal Chemistry.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

The master's specialisation Drug Discovery and Safety at Leiden University provides students with research-oriented education into the discovery of new drug targets and new lead molecules, particularly in the field of cancer, through a combination of advanced imaging techniques (‘systems microscopy’),…

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Life Sciences Artificial Intelligence Data Science

What are the conditions under which coercive diplomacy can compel a State to abandon its controversial nuclear (weapons) program? Based on the experience of the US coercive diplomacy against the nuclear programs of three countries, namely Iran, Libya and South Africa, Jean Yves Ndzana’s PhD research…

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

How can video on professional practices in university courses be used in a valid and useful way for assessment and feedback?

Can we bring novel treatment options to the clinic for UM patients with liver metastases?

Brenda M.S. da Silva and colleagues designed and validated the “Moral Emotions Questionnaire” (MEQ) for identifying three major moral emotions in preschoolers – allowing to separately measure guilt, shame and pride at the youngest ages.

Master

From Sunday 11 till Tuesday 20 June 2023, NVIC organizes a new edition of the TAFL course. This intensive, interactive course is developed for (future) teachers of Arabic. It addresses both the practical aspects of teaching Arabic as a foreign language as well as the underlying linguistic and cognitive…

Some children and adolescents find it hard to attend school because of anxiety and/or depression, a problem which is often referred to as school refusal. The main research question is how we can best help these young people reduce their emotional distress and increase their school attendance in order…

Master

Grassroots heritage initiatives and community engagement

Master

Master

Master

Master

Master

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

PhD defence

Opponents of drastic nitrogen measures argue that the nitrogen calculation model is not reliable enough. Nitrogen professor Jan Willem Erisman: 'It is now much more important to discuss the choices we make on the basis of the outcome. The differences are much bigger than the uncertainties in the mod…

Mechanisms fro drug resistance

The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.

Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.

Some conflicts involve many Muslims as foreign fighters; other conflicts attract only relatively few combatants from abroad. Isabele Duvesteyn and Bram Peeters

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Promotor: Prof.dr. J.N. Kok

The Heritage Quest project is a citizen science project in which volunteers participate in archaeological research.

A functional study of chert artefacts from preceramic sites in Colombia (2002)

This NWO-funded research programme focuses on the assumptions and methodology of the writing of history of science. History of science is in many respects a flourishing discipline: it currently yields an impressive volume of studies. Systematic reflection about the ways in which history of science may…

An overview of research projects at the Predictive Pharmacology group.

PhD defence

We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

PhD defence

PhD defence

How can the transport of molecules in living cells help to target medicines at exactly the right place?

The drug discovery pipeline is used to describe the stages in drug discovery. The earliest stage concerns with the identification of potential targets and molecules ('hits') that can modulate their function, while more advanced stages are about developing these hits into viable experimental drugs and…

PhD defence

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.