Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Holocaust scholars Barbara Engelking and Jan Grabowski will jointly hold the Cleveringa lecture on November 26. They were accused of defamation in Poland for a book they co-edited. How has this affected them? ‘This is an attempt to wear us down.’

What tools can be applied to measure the output, outcome and impact of science communication efficiently and effectively?

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

The BioMedical Metabolomics Facility Leiden (BMFL) offers a highly structured environment for advanced metabolomics studies. BMFL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome.

Project TARGET is a research project aimed at the relation between the illegal arms trade and firearm violence. In a study conducted in seven countries, the researchers took a look at the differences and similarities. Katharina Krüsselmann and Marieke Liem took a closer look at the situation in the…

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Political scientist Corinna Jentzsch received an NWO Veni grant for her research on the conditions of collaboration between militias and state forces and its consequences for safety and political order.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

An overview of the research at the Cancer Dug Target Discovery group.

Study information

Instead of the finger scanner we now use a QR code based access system for the USC location.

In what way is constructivist logic able to account for both the role of the judging agent in inference and the universal claims of logical validity?

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

The aim of this project is to foster a historiography that does justice both to the realization that scientific knowledge is constructed by local, contingent, and contextual processes, and the claims of science to objective validity.

On 25 November 2018, Laurens de Hoog defended his thesis 'De prioriteitsregel in het vermogensrecht'. The doctoral research was supervised by Prof. mr. W.G. Huijgen.

Using formal methods, we rigorously validate and verify functionality and security properties of essential Internet protocols. In this project, we unambiguously specify Internet protocols (i.e. IP, TCP, UDP, BGP, DNS) using Reowolf's Protocol Description Language (PDL).

A publication on the location of financial losses and the validity of jurisdiction clauses after the CJEU’s Kolassa v Barclays Bank and Profit Investment v Ossi judgments.

Promotor: B. van de Water

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

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Development and validation of instruments that can measure different aspects of emotional competence in children with normal and atypical development, and in different cultures

Presentations & Marketplace

If you intend staying in the Netherlands for longer than four months, or if you have been granted a student residence permit, you must register with your local Dutch town hall shortly after arrival. Sign up for your town hall appointment well in advance!

What can languages spoken in the Lesser Sunda Islands today tell us about the histories of its various population groups?

On Friday May 3rd 2013 NWO has announced that Dr. Mario van der Stelt, Division of Bio-Organic Synthesis (LIC) and Dr. Laura Heitman, Division of Medicinal Chemistry (LACDR), have been awarded with an ECHO-STIP grant for their project, entitled: “Novel target engagement biomarkers for better drug ca…

Inaugural lecture

Lecture

HomininSpace is an agent based modelling and simulation system in which fluctuating carrying capacity is the key attractor for hominin dispersal. A parameterized and spatially explicit reconstructed palaeo-environment models available energy in the form of secondary biomass using reconstructed climate…

The members of LUXs develop and validate new methods and algorithms for analysing data, and apply these in a wide range of problems. Their research ranges from multidisciplinary applications to proving mathematical theorems.

Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

Research is meant to generate knowledge, in a rational and sensible way. Many research methods exist to do this, and creativity is an important factor. Our mission is to explore creative, playful, unexpected, and unconventional forms of academic research.

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

PhD defence

PhD defence

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

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The following dissertation reconstructs Paul Natorp's philosophical psychology. It argues that psychology's main object is the lived experience of concrete subjects, understood as a transcendental structure of logical-reflexive conditions for the recognition, appropriation, and evaluation of objective…

The LUMC iPSC Hotel offers the generation of research grade human induced pluripotent stem cells (hiPSCs) from different tissue sources using state of the art reprogramming techniques.