Mechanisms fro drug resistance

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

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More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

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The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Research at the department of Environmental Biology

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

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This research programme aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services to facilitate strategic management of natural resources. To this end, we address urgent challenges in relation to the mechanisms involved…

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Along with your application, you will need to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Our team consists of the following members.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

Making predictions about emotional problems or the effects of air pollution: Marjolein Fokkema’s algorithms are getting better at this all the time. She is making her algorithms increasingly flexible, so they can predict not just characteristics at one particular moment, but also how skills, for example,…

Leiden biophysicist Stefano Coppola has received the prestigious AXA Research Fund postdoctoral fellowship. With this grant he can work for two years on a project to research the role of mechanical factors in the development of pancreatic cancer.

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Opponents of drastic nitrogen measures argue that the nitrogen calculation model is not reliable enough. Nitrogen professor Jan Willem Erisman: 'It is now much more important to discuss the choices we make on the basis of the outcome. The differences are much bigger than the uncertainties in the mod…

The drug discovery pipeline is used to describe the stages in drug discovery. The earliest stage concerns with the identification of potential targets and molecules ('hits') that can modulate their function, while more advanced stages are about developing these hits into viable experimental drugs and…

How can the transport of molecules in living cells help to target medicines at exactly the right place?

Mechanical interactions between cells and their environment play an important role in many biological processes.

The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…

Health research, medical practice and consequently the whole population is increasingly affected by digitization, data science and AI.

Collecting data in sports increased in importance the last few years.

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PhD Defence

Publication by: Anouk Wezel, Sabine Welten, Wida Razawy, Max Lagraauw, Margreet de Vries, Eveline Goossens, Martin Boonstra, Jaap Hamming, Ekambar Kandimalla, Johan Kuiper, Paul Quax, Yaël Nossent and Ilze Bot. Annals of Surgery. 2015;262:841-848.

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

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How can zebrafish research help to understand and fight human cancer?

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The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.