Lecture

PhD Defence

PhD Defence

The master's specialisation Drug Discovery and Safety at Leiden University provides students with research-oriented education into the discovery of new drug targets and new lead molecules, particularly in the field of cancer, through a combination of advanced imaging techniques (‘systems microscopy’),…

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

PhD Defence

By comparing individual health data with population data, doctors can provide personalized health advice and patients can learn from each other's experiences. Wessel Kraaij, professor of Applied Data Analytics shows how personal data can have predictive value.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. Only if you have a Dutch vwo diploma with wiskunde B, you won’t need to submit additional documents.

Promotor: J. Kuiper

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Gibbs processes, g-measures, fuzzy Gibbs states

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: Prof.dr. E.F. van Dishoeck, Co-promotor: S. Bruderer

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Can new variants of daptomycin and the polymyxins be found?

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

‘My name is Daan van Valkengoed, and I am a master student Bio-Pharmaceutical Sciences. Last year I conducted my bachelor research internship within the research group Predictive Pharmacology of the LACDR. During my research, I used a mathematical model developed by the Predictive Pharmacology group…

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We are moreover strongly involved in the Master specialisation of Pharmacy at Leiden University. We work on clinical problems that require further mechanistic understanding and…

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.

Sanne Kellij and colleagues systematically reviewed 142 articles, examining evidence for three hypotheses on the relation between victimization and social information processing.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…

What does site patterning reveal about the social landscape dynamics across the historical divide?

The master's specialisation Methodology and Statistics in Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Lecture

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

Grants awarded to molecular physiology research

Laura Heitman has been awarded a VIDI grant for her innovative drug research. Heitman strives to optimize a drug’s binding kinetics at its target in order to ultimately fight diseases effectively. She even pleads for a paradigm shift in drug discovery.

Legal scholars and professionals are confronted with a rapidly increasing volume of legal publications. Only part of these publications are relevant enough to be cited. This project aims to determine which documents that are, and whether alternative metrics are a reliable way to predict whether documents…

What is neutron star matter?

Political scientist Tom Louwerse (Leiden University), analysing several recent opinion polls, expects that after the March 2017 elections in the Netherlands, a relatively large number of mid-sized parties will gain representation in the Dutch parliament. If the predictions are anything close to the…

As of 1 November, Laura Heitman has been appointed full Professor of Molecular Pharmacology at the Leiden Academic Centre for Drug Research (LACDR). Heitman has been working on the understanding and improvement of drug-receptor interactions in early drug discovery. ‘My ultimate aim is to make medicines…

Course

Lecture

On this page you can find information about previous CCLS events.

PhD Defence

Nature Reviews Drug Discovery volume 18, pages 82–84 (2019). The implications of target saturation for the use of drug–target residence time Wilbert de Witte, Meindert Danhof, Piet van der Graaf, and Elizabeth de Lange