1,841 search results for “target engagement” in the Public website
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Profiling Endophenotypes in Social Anxiety Disorder – a family study
The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…
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Scientific research
The effectiveness of the intervention has been examined extensively among different groups of caregivers and children in both the Netherlands and abroad. Among these groups were children in high-risk situations, parents in high-risk situations/extraordinary circumstances and caregivers in childcare.…
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Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
- Dutch 5A
- Dutch 5B
- Japanese 1+2 Intensive Summer Course
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Systems pharmacology-based optimization of postoperative morphine treatment
Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.
- Spanish 3+4 Intensive Summer Course
- Dutch 1B
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New imaging technology to assess early drug success
Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…
- Dutch 2A
- Dutch 3B
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Receptor Residence Time
Research question
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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Determining the kinetic profile of ENT1 inhibitors
Supervisor: Anna Vlachodimou
- French 5+6 Intensive Summer Course
- Dutch 6B
- Dutch 4B
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Proteochemometrics
Research question
- Dutch 3A
- Séminaire pratique: Le Français Juridique
- Dutch 1 for speakers of German
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Personalized Medicine
Getting personal
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Research
An overview of the research at the Biologics Formulation group
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Selectivity
Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.
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Hit Discovery
The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.
- English 5 Intensive Summer Course
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Targeting Inter-Organ Cross-Talk in Cardiometabolic Diseases
PhD defence
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Modules
VIPP/VIPP-SD (the basic module) can be applied to most family situations. However, some modules have been adapted to suit specific target groups. After completing the four-day basic training for the VIPP-SD, professionals can be trained to apply these specific modules. We work together with various…
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Peptide Amphiphile Nanoparticles Enhance the Immune Response Against a CpG-Adjuvanted Influenza Antigen
Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.
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VSBfonds Beurs
Bachelor, Master, PhD
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Research opportunities
For students who wish to undertake a research project at Leiden University, there are a number of options available.
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Reversing cardiovascular diseases
How can the development of constrictions in the blood vessels be reversed?
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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Better ligands for G Protein-Coupled Receptors
The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.
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Mechanisms of melanoma-targeting antibody therapy in mice
PhD defence
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Efficacy, safety and novel targets in cardiovascular disease
PhD defence
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Inflammation as a target for treatment in hand osteoarthritis
PhD defence
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Exploring Grainyhead-like 2 target genes in breast cancer
PhD defence
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Targeting of antigen-presenting cells with mannosylated conjugates
PhD defence
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Diagnostic and Intraoperative Targeted Molecular Imaging for Pancreatic Cancer
PhD defence
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Clinical aspects of immunotherapy and targeted therapy of advanced melanoma
PhD defence
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Towards treatment of liver fibrosis; cells, targets and models
PhD defence
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Regulation of Target Proteins by Small Ubiquitin-like Modifiers
PhD defence
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Targeting HLA Class II in allogeneic stem cell transplantation
PhD defence
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Chikungunya virus nonstructural protein 1 as an antiviral target
PhD defence
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Oxidants and antioxidants as targets for cardiovascular disease prevention
PhD defence
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Targeted Therapy for Triple-Negative Breast Cancer
PhD defence
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Lipids as therapeutic targets for barrier repair in skin diseases
PhD defence
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Preclinical validation of putative targets in cardiovascular and metabolic disease
PhD defence