Source: PLoS ONE, Volume 10, Issue 3 (2015)

We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

The division of Drug Discovery and Safety combines the former divisions Toxicology and Medicinal Chemistry.

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

The master's specialisation Drug Discovery and Safety at Leiden University provides students with research-oriented education into the discovery of new drug targets and new lead molecules, particularly in the field of cancer, through a combination of advanced imaging techniques (‘systems microscopy’),…

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

What are the conditions under which coercive diplomacy can compel a State to abandon its controversial nuclear (weapons) program? Based on the experience of the US coercive diplomacy against the nuclear programs of three countries, namely Iran, Libya and South Africa, Jean Yves Ndzana’s PhD research…

PhD defence

PhD defence

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Assistance for refugee students, first-generation students, and students from Suriname and the Caribbean region of The Netherlands.

Opponents of drastic nitrogen measures argue that the nitrogen calculation model is not reliable enough. Nitrogen professor Jan Willem Erisman: 'It is now much more important to discuss the choices we make on the basis of the outcome. The differences are much bigger than the uncertainties in the mod…

Bert Fraussen, Assistant Professor at Leiden University, Adrià Albareda, a PhD candidate at Leiden University and Caelesta Braun, Associate Professor at Leiden University, identified combinations of consultation tools and analyzed their implications for stakeholder diversity.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Mechanisms fro drug resistance

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An overview of research projects at the Predictive Pharmacology group.

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.

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Lecture

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The drug discovery pipeline is used to describe the stages in drug discovery. The earliest stage concerns with the identification of potential targets and molecules ('hits') that can modulate their function, while more advanced stages are about developing these hits into viable experimental drugs and…

How can the transport of molecules in living cells help to target medicines at exactly the right place?

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

How can zebrafish research help to understand and fight human cancer?

The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…

Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…

PhD defence

PhD defence

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

Effectiveness and Side-effects.

Promotor: F.S. de Boer Co-promotor: P. T. de Gouw

A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

You can make some astounding images using just a box with a hole. Inspired by the celebration of Leiden as the European City of Science, Professor Matthew Kenworthy left several pinhole cameras across the Observatory over the course of 2021. This is how the simplest devices may uncover the greatest…

PhD defence

PhD defence

PhD defence