Is is possible to better predict the validity of drug candidates?

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Governance and Global Affairs, Leiden University College The Hague

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

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On 27 May 2021, Hirad Abtahi defended his thesis 'Adjudicating Attacks Targeting Culture'. The doctoral research was supervised by Prof.dr. C. Stahn.

Efficient gene-targeting during meiosis

Our education responds to questions and needs from society. With the knowledge and skills they acquire through education, empowered and critical citizens will be able to contribute to a better world. Students can already start contributing during their programme, with community-based projects (Service…

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Science, Leiden Observatory

Discovery of metastasis promoting candidate drug targets

Leiden University and VU Amsterdam are developing a joint research project for a digital platform on which you can compose and share storylines with the use of images. Such interactivity will make a boring high school history lesson much more exciting and personalized. Furthermore, it will stimulate…

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

This book brings together new research on the practices of newsmaking.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Doctors are expected to apply recent insights from research to improve patient care. This is one of the reasons for integrating research into medical education.

To assess the impact of illicit firearms trafficking on gun violence, this research looks at the scope, characteristics and contexts of firearm violence, and also the scope and nature of firearms trafficking in Europe since the new millennium. Nils Duquet, Dennis Vanden Auweele and Marieke Liem created…

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.

Stakeholder engagement practices are on the rise in regulatory governance. This raises an important question regarding implications for regulatory legitimacy. Engagement mechanisms are not by default legitimizing: Even when initiated to tap into an array of ‘benevolent’ desiderata, unless carefully…

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Pupils and students learn best if they are actively doing something with the material. Professor Wilfried Admiraal is studying the best teaching methods and assignments to achieve this.

How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?

De lichtheid van literatuur: Engagement in de multiculturele samenleving (The Lightness of Literature: Engagement in the Multicultural Society) is a plea for the social relevance of literature. The book delves into an age-old debate about literature and social engagement, which has recently been reinvigorated…

Nietzsche has often been considered a thinker independent of the philosophy of his time and radically opposed to the concerns and concepts of modern and contemporary philosophy. But there is an increasing awareness of his sophisticated engagements with his contemporaries and of his philosophy's rich…

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Science, Leiden Institute of Chemistry (LIC)

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Science, Leiden Academic Centre for Drug Research (LACDR)

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Project TARGET aims to improve our understanding of gun violence in Europe and the relationship between gun violence and firearms trafficking.

In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?

Source: ChemMedChem (2015)

Dendritic cells (DC) play a prominent role in the priming of CD8(+) T cells. Vaccination is a promising treatment to boost tumor-specific CD8(+) T cells which is crucially dependent on adequate delivery of the vaccine to DC.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Novel methods for understanding key aspects that are essential to the future of Bayesian inference for high- or infinite-dimensional models and data.

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

This project embarks on empirical analysis of popular psycho-physical practices in contemporary Korea.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.