Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Unraveling the immune-suppressive actions of drugs like prednisone.

Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.

Promotor: Prof.dr. A.W. van der Vaart

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Conference

Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?

PhD Defence

PhD Defence

Lecture

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

The Netherlands is not particularly rich in ‘wild nature’. Comparatively, what we have is a lot of intensively used agricultural land. This means that from nature’s perspective there much to be gained by combining the ‘nature’ and ‘agriculture’ functions. Not an easy task in such a densely populated…

The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…

Human activity at sea makes a terrible racket. To what extent does this disturb marine animals? PhD candidate Annebelle Kok studied the effect on harbour porpoises, long-finned pilot whales and their prey, and discovered the sheer complexity of the problem. PhD defence on 12 November.

Promotor: H.J.M. de Groot

An international team of astronomers including Leiden scientists publishes the image of a young star with a surrounding dust disk that is still being fed from its surroundings. The phenomenon around the star SU Aur may explain why so many exoplanets are not neatly aligned with their star. The European…

While there are numerous and extremely advanced methods to sequence the genome, only a few methods exist to sequence the proteome. The Vidi project of Grégory Schneider promises to shed light on the most difficult paradigm of proteomics: achieving an error-free determination of the sequence of single…

The latest research from the Leiden outdoor laboratory ‘Living Lab’ shows that the insecticide thiacloprid strongly influences even the most common and robust dragonfly species in the Netherlands. The study was published in the Journal of Applied Ecology.

Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.

Animal species that are dear to us in the Netherlands often spend a large part or all of their lifecycle in other parts of the world. But their habitats worldwide are under increasing pressure, are often inadequately protected and much poorer than the global average. ‘If we truly care about these animals,…

PhD student Wen Yang discovered how certain cell receptors in E. coli bacteria signal 'smells'. With the use of ice-cold electron microscopy microbiologists from Leiden gain more insight into how bacteria respond to their environment. Publication in mBio.

An international team with researchers from Leiden revealed how a bacterium repurposed an internal system to control its movements. Movement control is very important in host invasion, which can lead to disease. Publication on 27 April in Nature Communications.

An unexpected phenomenon in a merger of a cluster of galaxies. An international team of astronomers led by Francesco de Gasperin has witnessed a gas tail of a galaxy, that slowly extinguished, but then lightened up again

This article explores an emerging “cultural turn” in intelligence studies, which, if fully realized, could entail the expansion of the discipline to include new methodologies and theories, and a more integrative understanding of historical causality that locates intelligence agencies within the widersocio-cultural…

Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…

What can we learn from how maritime conflicts were managed in the past? What significance did Maritime Conflict Management have in shaping the standards of diplomacy and international law in pre-modern Atlantic Europe (1200-1600)?

Alicia Schrikker doesn't usually get involved in urban history. As a senior lecturer, her research field is generally the colonial history of Asia and partly South Africa. So, the fact that she is going to carry out an urban history research project together with colleagues, is something that even she…

The Netherlands is informal, friendly and welcoming. Everyone can feel at home here, regardless of religion, ethnic background or sexual orientation. The Dutch speak many languages and the countryside and cities are easy and safe to travel through, by any means of transport. No matter where you come…

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…

Parents often see that when their sweet, socially-minded children become adolescents they change into selfish 'hotel guests' who think only of themselves. But adolescents become increasingly better at weighing up one another's interests. This discovery has been made by development psychologist Rosa…

More than 60 European researchers and industry partners have set out their roadmap for the application of graphene in marketed products. Leiden chemist Grégory F. Schneider believes that graphene and other layered materials can in the future be used for DNA sequencing applications.

Using the motto 'Exploring humanities through the life of objects' the Thingsthattalk platform gives a voice to historical objects that are usually kept behind closed doors. Objects from various Leiden collections are going to be made public and placed within a historical and user context.

‘Make more room for nature on farmland and you'll be surprised at the result.' This was the advice from Geert de Snoo in his Dies lecture.

The enormous adaptability of the cholera bacterium explains why it is able to claim so many victims. Professor Ariane Briegel from the Leiden Institute of Biology has now discovered that this adaptability is due to rapid sensory changes in the bacterium. Publication in PNAS.

Lecture

Lecture, Studium Generale

Bird, butterfly, fish: when you look through a children’s book, you usually don’t think about the fact that humans divided these animals, depicted in bright colours, into categories. Yet, this division has been discussed for centuries. In her PhD dissertation, Didi van Trijp shows how natural scientists…

Lecture

Lecture

This programme aims to identify the intellectual contexts that were of importance for the architectural theory of the period, and especially to clarify the relation of architectural theory to primitivism.

‘To be honest, I knew very little about the Netherlands when I arrived in 1998. But studying law in Leiden was a very enriching experience.’ Nathalie van den Berge grew up in a number of different European countries, and now works at a UN office in Tanzania, where she lives with her Dutch husband and…

With his dance routine and YouTube clips, he even manages to make grammar fun. His infectious enthusiasm and innovative teaching methods have won Thijs Porck, a lecturer in Old and Middle English, a nomination for the LUS Teaching Prize.

Liposomes – nano-sized spheres composed of fatty molecules – are very promising for vaccination. Bio-pharmaceutical scientist Naomi Benne discovered that the immune response in animal models can be steered by varying the charge of the liposomes. She obtained her PhD degree on 8 September for this research,…