Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Navarro Paredes

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Chemical biology research aims at understanding and manipulating biological processes at the molecular level. Physiological processes that are behind human disease are subject of detailed chemical biology studies with the aim to identify new drug targets, but also leads for drug development or that…

We investigate emergent structures and dynamics of soft materials self-assembled from microscopic constituents.

Can cyclic peptides provide a new generation of antibiotics?

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

Can the pink-pigmented microbe Methylobacterium extorquens be genetically engineered to convert the sustainable raw material methanol into antibiotics?

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

This research programme aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services to facilitate strategic management of natural resources. To this end, we address urgent challenges in relation to the mechanisms involved…

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

Debate, Discussion evening on synthetic biology

Overkleeft

Promotores: Wim Jiskoot; Ferry Ossendorp

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Science, Leiden Institute of Chemistry (LIC)

PhD Defence

The master’s programme Biology at Leiden University offers seven specialisations ranging from Cell Biology to Molecular Genetics. The programme prepares you for a career in research within or outside academia.

Biology is the study of life. Are you interested in understanding life, from the molecular level to entire ecosystems? Do you want to use your understanding and knowledge of biology to benefit the health of both humans and the environment? If so, Biology is the right study programme for you.

The Leiden students who participated in the iGEM synthetic biology competition have won the prize for best production. They developed a way to have bacteria produce the substance suckerine, a protein derived from the Humboldt squid. By doing so, they want to help heal burn wounds. ‘The announcement…

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

The master’s specialisation Biology and Education at Leiden University prepares students to teach the subject of biology to secondary school students. The programme comprises a one-year Biology component, followed by an education component in the second year.

The master’s specialisation Evolutionary Biology at Leiden University investigates biology at all levels. The specialisation includes genomics, functional developmental genetics, paleobiology, behavioral biology and evolutionary ecology.

The Programme Committee Biology (Opleidingscommissie Biologie, OCB) consists of four teaching staff members and five students, and is assisted by the study adviser. The OCB has an independent position within the Biology education program. Because of its composition, the OCB is the most important organ…

Brings you the weirdest, funniest, most memorable biology of the moment!

The Leiden Institute of Chemistry is proud to offer the “Leiden Chemical Biology Lectures”. This lecture series aims to bring excellent researchers in the field of chemical biology to our university, and to expose our students to top science conducted in this area.

Nature is a never-ending source of inspiration for the researchers at the Institute of Biology Leiden (IBL). Based on a better fundamental understanding of nature, they are able to seek solutions in the area of health and biodiversity. The theme of IBL is ‘Harnessing biodiversity for health.’

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

The master’s specialisation Biology and Business Studies at Leiden University bridges science and business development by focusing on areas such as technology management, innovation, entrepeneurship, operations, and decision making.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

This activity is currently not offered. An (online) alternative is being sought.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

Science, Institute of Environmental Sciences (CML)

The master’s specialisation Biology and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in biology with extensive training in science communication.

The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…