40 search results for “surfactant-based vesicle” in the Public website
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Characterization and skin permeation of ketoprofen-loaded vesicular systems
PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.
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Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity
The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.
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Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Membrane Interactions
Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…
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Extracellular vesicle therapeutics for cardiac repair
PhD Defence
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
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Peptide amphiphiles and their use in supramolecular chemistry
Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros
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Publications
A selection of recent publications from the Plant BioDynamics Laboratory.
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…
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Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
PhD Defence
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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3D Cell Environments
Living cells on topographically-controlled substrates: Understanding Cell Motility in a Quasi-3D Environment
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Evolution and development of bitterling fish
How has early development in R. ocellatus been modified as a result of its parasitic embryonic lifestyle?
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Parkinson Protein α-Synuclein Binds Surprisingly Strong with Membrane
Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.
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Cleaning up tuberculosis and salmonella infections
The cellular recycling system in zebrafish is capable of eating harmful bacteria and thus resist infections such as tuberculosis and salmonellosis. That is written by Leiden biologists from the group of Annemarie Meijer. Stimulating this form of defence could be used in new treatment methods against…
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Supramolecular materials: from biosensors to cell delivery devices
The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…
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Intracellular Transport
Bead microrheology: Analysis of active and passive transport in living cells
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New method of detecting rapid virus development
Physicists, including Leiden researcher, Sanli Faes, have devised a new technique for studying processes at microscale rapidly and extremely precisely. This new method will make it easier to develop antiviral medication. And it doesn’t stop there. Publication in ACS Nano.
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Auxin
Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.
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Light-activatable metallodrugs and metal-functionalized liposomes
Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…
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New project funded to study Alzheimer's disease
Researchers from Leiden University will develop a new approach to study the biomarkers of Alzeimer’s disease. This approach focusses on the molecular messengers of the cells. The project, led by Thomas Hankemeier and coordinated by Yuliya Shakalisava (Leiden Academic Centre for Drug Research, LACDR),…
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This Week's Discoveries | 18 June 2019
Lecture
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Two-photon microscope captures plant cells
Leiden physicists are helping Wageningen plant researchers to study unpredictable plant embryos. For this, they are using a novel two-photon fluorescence microscope, aided by a 30 thousand euro ZonMW grant.
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New insights for improved pertussis vaccines - Press release -
Researchers in Bilthoven, The Netherlands, have recently unraveled the defense against whooping cough bacteria in unprecedented detail. The outcome of the project, conducted at Intravacc (Institute for Translational Vaccinology) in Bilthoven, provides opportunities for a new approach in the development…
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Cancer vaccine packaged in minute particles
Leiden researchers have carried out successful tests using a new method of packaging a cancer vaccine in nano-particles. The new vaccine has induced a strong immune reaction in mice. The researchers believe that this method can make an important contribution to the treatment of cancer. Their findings…
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Mathematical model helps to explain the formation of spine and ribs
Mathematical biologists from Leiden have developed a model that helps to explain how the spine and vertebrae, among other things, form during embryonic development. The same process, the other way around, plays a key role in cancer metastasis. Publication in iScience.
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@ThroughOcular shows the beauty of plants, fungi and algae
Beautiful microscopic specimens play the leading role in the course 'Biodiversity Plant' for first-year Biology students. Normally these are put back in storage right after the course. But not this year!
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This is how a channel is formed between two organelles
The channel through which two cell components exchange material appears to form at the edge of their contact surface, and not in the middle. This was discovered by the Leiden physical chemists Jelger Risselada and Edgar Blokhuis together with researchers from the University of Lausanne in Switzerland.…
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Research projects
An overview of research projects at the Predictive Pharmacology group.
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SSNMR Lecture - Molecular disease mechanisms in neurodegeneration: solid-state NMR studies of protein aggregation and mitochondrial lipid oxidation
Lecture
- Advanced Drug Delivery and Targeting Course
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Theses
Full texts of all bachelor, master and PhD theses are available on this site