Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Vaccination via the skin or the mucosae

Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…