In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

Promotor: Prof.dr. G.P. van Wezel

An interdisciplinary cultural analysis of how the Hindustani double migration informs contemporary processes of identification and problematises the juxtaposition of tradition and modernity.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

PNAS publication on protein encounter complexes

Prostate cancer (PCa) is one of the most prevalent cancer in males.

The most commonly used method for the taxonomic identification of tree trunks is wood anatomy. The number of experts in this area is decreasing, and education to become an wood anatomists takes many years. With the help of technology computer scientists of the Leiden Institute of Advanced Computer Science…

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Promotores: Bas Edixhoven, Guy Henniart

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

On the 13th of November, Hanna Fricke successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Hanna on this achievement.

The unit residue group, to which the present thesis is devoted, is defined using the norm-residue symbol, which Hilbert introduced into algebraic number theory in 1897.

In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.

How do inclusion and exclusion affect people?

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Read about the impact of past research

Promotores: S.J. Edixhoven, P.Parent

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

This study offers a comprehensive but balanced grammatical analysis of Ik (Icetod), Northeast Uganda’s last thriving Kuliak language.

When did the Mali Empire disintegrate? What does the Sunjata heritage demonstrate about the political situation after 1600?

Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Universite Bordeaux I)

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The Gymclub is a sub-group of ProParte.

The Museum club is a sub-group of ProParte.

Which adolescents are more at risk of developing social anxiety disorder later in life?

Can animal venoms yield novel antimicrobial peptides?

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

PhD Defence

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Schneider

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

This project explored the role of material culture, in casu painted plaster and its technologies, in expressing dynamic social identities and in forging complex interwoven human relationships in the context of the Middle to Late Bronze Age of the Aegean and East Mediterranean.

We cover the entire spectrum from target identification to the evaluation of the efficacy and safety of novel medicines in clinical practice.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Education in (Chinese) Medicinal Plants associated to the Hortus botanicus in Leiden - Which Traditional Chinese Medicinal plants can be grown in the Hortus? - Establishing of a database which Chinese medical plants are available in Dutch Botanical Gardens - Data validation (correct identification,…

On November 21st, Frederick Boswell succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Frederick on this great result.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…