1690 search results for “structurekinetics relationships” in the Public website
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Structure-affinity relationships (SARs) and structure-kinetics relationships (SKRs) of Kv11.1 blockers
Source: J Med Chem (2015)
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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as
Source: Eur J Med Chem (2015)
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Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists
Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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The Role of Target Binding Kinetics in Drug Discovery
Source: ChemMedChem (2015)
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Affinity
Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists
Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.
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Binding kinetics
A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…
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Evaluation of (4-Arylpiperidin-1-yl)cyclopentanecarboxamides As High-Affinity and Long-Residence-Time Antagonists for the CCR2 Receptor
Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Arguably augmented reality : relationships between the virtual and the real
This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.
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Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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Citizenship: relationship between citizens and state
Leiden researchers study the extent to which Asian citizens can invoke the rights that they have on paper. This knowledge helps them advise the different levels of government and NGOs on how to improve the lot of poor citizens in particular.
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Receptor Residence Time
Research question
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Stay or leave? Veteran teachers’ relationships with students and job satisfaction
Dissatisfied older teachers regularly quit teaching before reaching retirement age. In her dissertation, Ietje Veldman advocates specific coaching for this group to retain them for education.
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practical knowledge, discipline strategies, and the teacher-class relationship
Social aspects of the learning environment, also called classroom climate, are important for students’ cognitive and affective learning outcomes. In this thesis the classroom climate is operationalised by means of two components: the teacher-class relationship and classroom discipline.
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of human gut (colon cancer) target site concentrations and PKPD relationships
The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.
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Better ligands for G Protein-Coupled Receptors
The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.
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The Relationship between State and Religion in a Changing Dutch Society
In recent decades, the Netherlands’ struggle with multiculturalism has caused an upsurge in public interest in the relationship between state and religion. In this, the Dutch address a subject relevant not just to them, but to all of Europe.
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Gender in ethnically mixed relationships of immigrants from Dutch former colonies in the Netherlands, 1945-2005
Subproject of "Differences that make all the difference. Gender, migration and vulnerability (migration to the Netherlands 1945-2005)"
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PhD candidate to study the relationship between protein folding and metal-binding
Science, Leiden Institute of Chemistry (LIC)
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The relationship between gesture, affect and rhythmic freedom in the performance of French tragic opera from Lully to Rameau
The links between gesture affect and rhythmic freedom in the performance of the tragédie en musique are explored in a number of videos.
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and the Legitimation of Violence: A Cross-National Analysis on the Relationship between Terrorism and Homicide Rates
This article written by Marieke Liem & Alexander Kamprad investigates the relationship between terrorism and interpersonal violence. They conducted cross-national analyses on the effects of terrorism mortality rates on homicide rates. Results showed that terrorism appears to be robustly and positively…
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the most appropriate dose metrics for evaluating dose-response relationships of metal-based nanoparticles to Zebrafish embryos
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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The noise of the hunt: effects of noise on predator-prey relationships in a marine ecosystem
The effects of anthropogenic noise on interactions between predators and their prey are still little understood.
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The rise of a capital: on the development of al-Fusṭāṭ‘s relationship with its hinterland, 18/639-132/750
This thesis studies the relationship of the town al-Fusṭāṭ, located at the southern end of the Nile delta in Egypt, and its hinterland in the period between the town’s foundation in A.D. 641 and the arrival of the Abbasids in 750.
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists
Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)
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The relationship between gesture, affect and rhythmic freedom in the performance of French tragic opera from Lully to Rameau
Baroque flautist Jed Wentz followed two years of dancing classes in order to develop the right feeling for the gestures required for the Baroque French opera genre ‘tragédie en musique’. In his dissertation, the links between gesture affect and rhythmic freedom in the performance of the tragédie en…
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Hanneke Palmen
Faculteit Rechtsgeleerdheid
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Human Robot Personal Relationships, 23-24 June 2010, Leiden University
The 3rd International Conference on Human-Robot Personal Relationships (HRPR 2010) is the most important platform for presenting an discussing studies of personal relations with artificial partners, their forming, their possibilities and their consequences.
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New database reveals plants' secret relationships with fungi
Leiden researchers have compiled information collected by scientists over the past 120 years into a database of plant-fungal interactions. This important biological data is now freely available for researchers and nature conservationists. Publication in New Phytologist.
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Humans and animals: how is their relationship defined?
Speakers from all over the world offered their interesting views on the relationship between humans and animals during the LUCAS Graduate Conference, based around the central theme ‘Animals: Theory, Practice, and Representation’.
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Direct relationship between depression and inflammation called into question
Depression has traditionally been linked to increased inflammation. Innovative research by psychologist Eiko Fried refutes this popular assumption. He shows that specific depression symptoms such as sleeping problems explain this relationship. Publication in Psychological Medicine .
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Publications
Here you can find our most recent research publications
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How does social distancing affect the relationship between population groups?
Hardly ever before have different groups in the population retreated into their own bubble as much as they are doing today. Professor of Sociology and Law Maartje van der Woude and her students will be examining the effect of social distancing on relationships. How do the people of Leiden look at students…
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‘A good relationship is a teacher's best asset'
During the opening of the academic year, true to tradition the LUC Teaching Prize will be awarded to the best lecture at the University. Get to know the nominees. This week: Christine Espin.
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Underwater noise affects marine animals’ relationships. But to what extent?
Human activity at sea makes a terrible racket. To what extent does this disturb marine animals? PhD candidate Annebelle Kok studied the effect on harbour porpoises, long-finned pilot whales and their prey, and discovered the sheer complexity of the problem. PhD defence on 12 November.
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SASE Conference: The multifaceted relationship between value and the firm
On Monday 20 July 2020, members of the Business & Liability Research Network (BLRN), Tim Verdoes (Business Studies), Jelle Nijland and Gert-Jan Boon (both Corporate Law) contributed to the online conference Society for the Advancement of Socio-Economics (Sase). This years' conference was themed 'Development…
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Receptor Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Contract law offers framework for legal relationship between pupils and schools
When a pupil applies for a place at a school and is admitted, a legal relationship is established between them. The exact nature of this legal relationship however is unclear. The law is silent in this area and case law provides no definite answer either. According to PhD Candidate Stijn Voskamp, contract…
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The relationship between LGBT inclusion and economic development: Macro-level evidence’,
The relationship between LGBT inclusion and economic development: Macro-level evidence
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Grants & Awards
Grants awarded to molecular physiology research
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Kees Waaldijk
Faculteit Rechtsgeleerdheid
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Christa Tobler 2x on Swiss television on the relationship between Switzerland and the EU
Christa Tobler appeared as an expert on European law in the political programme "Arena" on Swiss television on 28 September 2018.
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American presidents and their special relationship with Leiden
President John Quincy Adams studied in Leiden. His father, John, who was also president, also stayed here and received a lot of support from professor and publisher Johan Luzac. And how are presidents Bush and Obama linked to Leiden?
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Wilma Wentholt
Faculteit der Sociale Wetenschappen
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‘Relationship between the state and religious and ideological beliefs in Belgium has reached its best-before date’
In Belgium, officially recognised religions receive financial support from the state. Partly as a result, there is no clearly implemented secularism (separation of church and state) though this is considered to be a guiding notion in modern constitutional theories. PhD candidate Alain Vannieuwenburg…