Source: J Med Chem (2015)

Source: Eur J Med Chem (2015)

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Source: ChemMedChem (2015)

Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

Promotor: A.P. IJzerman

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Leiden researchers study the extent to which Asian citizens can invoke the rights that they have on paper. This knowledge helps them advise the different levels of government and NGOs on how to improve the lot of poor citizens in particular.

Research question

Dissatisfied older teachers regularly quit teaching before reaching retirement age. In her dissertation, Ietje Veldman advocates specific coaching for this group to retain them for education.

Social aspects of the learning environment, also called classroom climate, are important for students’ cognitive and affective learning outcomes. In this thesis the classroom climate is operationalised by means of two components: the teacher-class relationship and classroom discipline.

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

In recent decades, the Netherlands’ struggle with multiculturalism has caused an upsurge in public interest in the relationship between state and religion. In this, the Dutch address a subject relevant not just to them, but to all of Europe.

Subproject of "Differences that make all the difference. Gender, migration and vulnerability (migration to the Netherlands 1945-2005)"

Science, Leiden Institute of Chemistry (LIC)

The links between gesture affect and rhythmic freedom in the performance of the tragédie en musique are explored in a number of videos.

This article written by Marieke Liem & Alexander Kamprad investigates the relationship between terrorism and interpersonal violence. They conducted cross-national analyses on the effects of terrorism mortality rates on homicide rates. Results showed that terrorism appears to be robustly and positively…

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

This thesis studies the relationship of the town al-Fusṭāṭ, located at the southern end of the Nile delta in Egypt, and its hinterland in the period between the town’s foundation in A.D. 641 and the arrival of the Abbasids in 750.

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Baroque flautist Jed Wentz followed two years of dancing classes in order to develop the right feeling for the gestures required for the Baroque French opera genre ‘tragédie en musique’. In his dissertation, the links between gesture affect and rhythmic freedom in the performance of the tragédie en…

The 3rd International Conference on Human-Robot Personal Relationships (HRPR 2010) is the most important platform for presenting an discussing studies of personal relations with artificial partners, their forming, their possibilities and their consequences.

Leiden researchers have compiled information collected by scientists over the past 120 years into a database of plant-fungal interactions. This important biological data is now freely available for researchers and nature conservationists. Publication in New Phytologist.

Speakers from all over the world offered their interesting views on the relationship between humans and animals during the LUCAS Graduate Conference, based around the central theme ‘Animals: Theory, Practice, and Representation’.

Depression has traditionally been linked to increased inflammation. Innovative research by psychologist Eiko Fried refutes this popular assumption. He shows that specific depression symptoms such as sleeping problems explain this relationship. Publication in Psychological Medicine .

Here you can find our most recent research publications

Hardly ever before have different groups in the population retreated into their own bubble as much as they are doing today. Professor of Sociology and Law Maartje van der Woude and her students will be examining the effect of social distancing on relationships. How do the people of Leiden look at students…

During the opening of the academic year, true to tradition the LUC Teaching Prize will be awarded to the best lecture at the University. Get to know the nominees. This week: Christine Espin.

Human activity at sea makes a terrible racket. To what extent does this disturb marine animals? PhD candidate Annebelle Kok studied the effect on harbour porpoises, long-finned pilot whales and their prey, and discovered the sheer complexity of the problem. PhD defence on 12 November.

On Monday 20 July 2020, members of the Business & Liability Research Network (BLRN), Tim Verdoes (Business Studies), Jelle Nijland and Gert-Jan Boon (both Corporate Law) contributed to the online conference Society for the Advancement of Socio-Economics (Sase). This years' conference was themed 'Development…

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

When a pupil applies for a place at a school and is admitted, a legal relationship is established between them. The exact nature of this legal relationship however is unclear. The law is silent in this area and case law provides no definite answer either. According to PhD Candidate Stijn Voskamp, contract…

The relationship between LGBT inclusion and economic development: Macro-level evidence

Grants awarded to molecular physiology research

Christa Tobler appeared as an expert on European law in the political programme "Arena" on Swiss television on 28 September 2018.

President John Quincy Adams studied in Leiden. His father, John, who was also president, also stayed here and received a lot of support from professor and publisher Johan Luzac. And how are presidents Bush and Obama linked to Leiden?

In Belgium, officially recognised religions receive financial support from the state. Partly as a result, there is no clearly implemented secularism (separation of church and state) though this is considered to be a guiding notion in modern constitutional theories. PhD candidate Alain Vannieuwenburg…