Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: B. van de Water

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

High throughput microscopy

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

What is the role of stress and stress-related hormones in emotion regulation?

How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?

Promotor: B. van de Water

How is the development of physiological responses to social evaluation in adolescence affected by other normative developments, such as pubertal, socio-cognitive and psychosocial development? Are social anxiety and public speaking anxiety associated with characteristic patterns of stress responses…

Does a universal psychoeducational course about stress in adolescents: I) lead to an increase in knowledge of stress?, II) affect the frequency with which stressors are experienced and the overall stress level?, III) create interest in a tier 2 level follow-up training?, and IV) appeal to students in…

Promotor: Prof.dr. J. Kuiper

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

Being a student can be stressful. Study pressure, living on your own, moving country, financial stress: things can be difficult. Unexpected difficulties may lead to study delay.

With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.

What is the effectiveness of two school-based skills-training programs in promoting mental health?

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

Although exposure therapy is the gold-standard treatment of posttraumatic stress-disorder (PTSD), only half of the patients adequately benefit from it. Based on recent insights into the mechanisms of extinction, this project examines strategies and techniques to improve exposure treatment outcome in…

Can epigenetic changes explain associations between early life stress and health outcomes?

The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.

How can we facilitate the early recognition of stress and anxiety in the classroom and collaborate with schools in providing low-threshold interventions?

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

What role play stress and fear in forming of nocebo hyperalgesia?

Our vision of stress is starting to change fundamentally. We can suffer stress without even being aware of it, while sleeping as wall as during the day. Professor of Psychology Jos Brosschot will discuss this phenomenon in his inaugural lecture on 2 December.

What are the behavioral, cognitive, and motivational consequences of decision reversibility?

PhD defence

In response to the challenges imposed by the COVID-19 pandemic, governments worldwide adopted a variety of strategies that include not just preventive or mitigation strategies adopted to 'flatten the curve', but also interventions aiming to mitigate economic and social impacts of the pandemic.

The minor Responsible Innovation is a unique collaboration between Leiden University, Delft University of Technology and Erasmus University Rotterdam. The programme offers in-depth insight into how responsible innovation can be accomplished and promoted.

To what extent is sound a stressor to fish? And are behavioural and physiological phenotypes equally sensitive to disturbance by noise pollution?

Here we provide information on the ways through which the Institute of Psychology aims to foster responsible scholarship practices: conducting research with integrity, and meeting the needs for better quality and efficiency in psychological science.

What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?

Unraveling the immune-suppressive actions of drugs like prednisone.

I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Stress, burnout, depression – these conditions pervade all levels of our society. Children and students suffer from constant pressure to achieve; at the international level, tensions lead to short-sighted actions; and, at the personal level, stress affects our health and social environment. How do our…

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

All biological and bio-medical research carried out at Leiden University is subject to strict conditions.

On Wednesday 13 December, Melanie Fink defended her doctoral thesis ‘Frontex and Human Rights: Responsibility in “Multi-Actor Situations” under the ECHR and EU Public Liability Law’. The supervisors are Rick Lawson and Jorrit Rijpma from Leiden, as well as Manfred Nowak, and Stephan Wittich from the…

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.

Ilze Bot and Johan Kuiper have published in The Lancet: Study unveils how stress may increase risk of heart disease and stroke. Aso: The National Dutch newspaper 'NRC' has mentioned them in a column