24 search results for “streptomycetes” in the Public website
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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The quest for more antibiotics
Streptomycetes are similar to moulds, but these bacteria live in the soil. They are very popular in biotechnology because they produce a great many antibiotics and enzymes. Gilles van Wezel will be using his Vici subsidy to study ways of increasing their production.
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Morphogenesis and heterogeneity in liquid-grown streptomyces cultures
The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Streptomyces as cell factories
We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Growth and development of actinomycetes
We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.
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Regulatory networks in Streptomyces
We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.
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PROTEOMINING: a novel proteomics-based pipeline for drug and enzyme discovery in filamentous actinomycetes
Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Molecular characterization of copper-dependent enzymes involved in Streptomyces morphology
Promotor: G.P. van Wezel, Co-promotor: D. Claessen
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Participants
The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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Scientists discover how to improve the production of antibiotics and enzymes in soil bacteria
A team of researchers at the Institute of Biology Leiden, in collaboration with scientists from Utrecht University, has discovered a novel approach to improve the production of antibiotics and enzymes in the soil bacteria Streptomycetes.
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Lizah van der Aart makes glossy about PhD research
After four years of hard work, the time has finally come: your thesis is finished. But who of your family and friends will ever read it? Biologist Lizah van der Aart decided to make a magazine for layman. 'It was precisely the explanation of the difficult, fundamental parts that gave me good tools for…
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Altruism in bacteria: colonies divide the work
Bacteria found in soil specialise in the colony by division of labour. Some of the bacteria produce antibiotics, even when it comes at the expense of their individual reproduction success, to defend their colony against competitors. Publication in Science Advances.
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How mammoth poop contributes to antibiotics research
PhD student Doris van Bergeijk brought 40,000-year-old bacteria from mammoth poop back to life. She hopes to find new information that can help research at the Institute of Biology Leiden into antibiotics and antibiotics resistance. Read about it on European Antibiotic Awareness Day, 18 November.
- In the Spotlight - Biology Seminars Leiden
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New insights into the production of antibiotics by bacteria
Bacteria use antibiotics as a weapon and even produce more antibiotics if there are competing strains nearby. This is a fundamental insight that can help find new antibiotics. Leiden scientists Daniel Rozen and Gilles van Wezel published their research results in the authoritative Proceedings of the…
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Van Leeuwenhoek lecture on Bioscience
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This Week’s Discoveries | 13 March 2018
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This Week's Discoveries | 10 December 2019
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This Week’s Discoveries | 19 December 2017
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