Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.

Science, Mathematical Institute (MI)

Lecture, Workshop

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

Sjaak Neefjes, Professor of Chemical Immunology at Leiden University, will receive the NWO Spinoza Prize this year. The Spinoza Committee called Neefjes an ‘exceptional researcher whose intelligence is matched by his boldness’. He will use the 2.5 million euro prize to pursue his research into cancer…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

The Equadiff conferences are a series of international meetings devoted to the field of differential equations in the broadest sense. Spread all over Europe, recent locations include Bratislava (2017), Lyon (2015), Prague (2013), Loughborough (2011), Brno (2009), Vienna (2007), Bratislava (2005),…

Good teaching lays the foundations for the future. All schoolchildren and students should be given the opportunity to get the best out of themselves. Teachers and lecturers are a determining factor for the quality of the teaching. That is why teachers and lecturers are central to the research at the…

PhD Defence

Heart failure is a major health care problem with high mortality.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

PhD Defence

Lecture

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Leiden scientists are the main applicants for five projects that have been awarded a Science Groot grant of up to 3 million euros in the Science Domain. In addition, several Leiden scientists are involved in other projects that have been awarded funding.

Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…

The main purpose of this book is to give a description of the Cholón language as represented in the Arte de la lengua cholona (ALC), a colonial grammar written in 1748 by a Franciscan friar, named Pedro de la Mata. The ALC was transcribed by Fray Gerónimo Clota in 1772. This grammar is kept in the British…

Central Limit Theorem associated to a particular case of ergodic total automorphisms. Finally, Chapter 6 proves that the isoperiodic foliation is connected for a meromorphic differential with three poles on a torus.

Software and Data of the department Industrial Ecology

Behavioral and neural mechanisms underlying risky decision-making in adolescents

Physicians and researchers of the Leiden University Medical Center (LUMC) and Leiden University are working on therapies for restoring damaged organs such as hearts and kidneys. They are even trying to construct tailor-made organs. Read more on this topic in the new science dossier on Vascular and Regenerative…

Is it possible for sugar patterns on cells to activate the immune system to combat cancer?

This research group is interested in the physics of living cells, especially their cytoskeleton dynamics under defined external stimuli.

We consider the propagation of electrical signals through nerve fibres.

Lecture

The research group headed by Ilze Bot aims to elucidate the mechanisms that underlie atherosclerotic plaque destabilization, which is the key process that leads to acute cardiovascular syndromes such as a myocardial infarction or stroke.

Actin Polymerization and Membrane Physics in Living Cells: Analysis of cell spreading mechanisms

PhD Defence

How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?

Robin de Jong

Overview of CML software and data

This project explores the religious lives of a Surinamese Hindu community practicing in Amsterdam at the Sri Radha Krishna Mandir from an interdisciplinary perspective.

Control of Living Cells by Magnetic Fluorescent Nanoparticles

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…