Behrouz Karoubi defended his thesis on 15 June 2016

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

This dissertation provides a formal description of the relationship between diatopic/diachronic micro-variation and phonologization through analysis of the phonetic/phonological properties of unstressed vowel reduction and vowel insertion in two Northern Italian dialects.

To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?

Promotores: Prof.dr. G.R. de Snoo & Dr. R. Heijungs

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

In this research project Nizar Rohana analyzes and reflects on taqsīm recordings by two leading figures of ‘ūd playing who were pillars of modern Arabic music, namely the Egyptians Muḥammad al-Qaṣabjī (1898-1964) and Riyāḍ al-Sunbāṭī (1906-1981).

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Science, Institute of Environmental Sciences (CML)

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

How can the transport of molecules in living cells help to target medicines at exactly the right place?

Promotores: H. Schiessel, G.T. Barkema

Promotor: Prof.dr. M.K. Richardson

The habitats of freshwater fish species are threatened by global warming, mainly due to rising water temperatures. This is the conclusion of a study led by Radboud University, in collaboration with Utrecht University, PBL Netherlands Environmental Assessment Agency, Leiden University and others. The…

A new plant species was named after Paul Kessler, prefect of the Leiden Hortus botanicus. Kessler discovered the small tree, which is related to the kiwifruit, himself.

Leiden scientists have discovered a new plant genus with two new species at a potential nickel mine site in Indonesia. Remarkable characteristic of the plants: they store manganese in their leaves.

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Coral reefs throughout the world are under threat. After studying the reefs in Malaysia, Zarinah Waheed concluded that there is room for improvement in coral reef conservation. PhD defence 22 November.

What are the phylogenetic relationships among the members of speciation bursts?

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

Planets are formed in disks of gas and dust around young stars.

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

Prostate cancer (PCa) is one of the most prevalent cancer in males.

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

On the 30th of September Christine Ketel successfully defended a doctoral thesis and graduated.

This thesis describes the use of the evolutionary approach in the study of language change, aiming to provide a better insight in the mechanisms that play a role in language change and to validate this approach in the field of language change.

Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.

A practical checklist with legal, technical and ethical points of view will from now on guide the data scientists when working in Artificial Intelligence: the AI Impact Assessment (AIIA). It has been developed by ECP (Platform of the Information Society) and nine other partners, among them the Leiden…

How can we quantify the density of species within a community through environmental DNA concentrations?

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

Which traits and/or trade-offs determine benefits of being deciduous or evergreen?

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.

Wen Yang is our Institute of Biology Leiden's nominee for the C.J. Kok Jury Award 2020.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Does a moving hybrid zone leave a genomic footprint?

This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…

What invertebrates live in the fields and edges? Do the populations change with landscape complexity?

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.