Where did species survive the cold cycles of the current Ice Age?

Which traits did change due to the invasion process of plants and how do these traits contribute to the invasiveness of such species. What is the role of carbohydrate accumulation? What is the function of carbohydrate accumulation in plants? Is genetic variation depleted in invasive species under se…

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

How can species literacy in the Netherlands be explained and improved?

Statistical distributions in LCA and converting between different representations of these distributions.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Do understudied animals contain hidden species?

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

What impact does a mid-season wildfire have on grassland invertebrates?

In the last couple of decades an ‘animal turn’ has taken place in the social sciences. This has led to a call to study social issues by including non-human animal perspectives. This Collaborative Research Group thinks it's high time that African Studies joins the chorus of minds that try to contribute…

Does a mid-season fire impact invertebrate populations?

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

Promotor: Prof.dr. E. Smets, Dr. M. Stech

The objective of this study is to better understand the distribution of microplastics in the environment. More specifically, we will quantify the abundance and distribution of microplastics on beaches.

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.

Development of Natural Resource for New Medicines

Science, Institute of Biology Leiden (IBL)

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

Science, Institute of Biology Leiden (IBL)

Does the presence of Ring-necked parakeets negatively influence feeding and feeding behaviour of native bird species on artificial bird feeders and if so, what are possible solutions?

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

The book 'Dutch Income (Re)Distribution, trends 1977-2019' was published on the 14th of October. Files related to the project can be downloaded via this website.

Over the last decades, income inequality has increased globally. How do social policies affect this increasing trend? How do international trade and technological progress affect inequality? What is the profile of income inequality in China?

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Promotor: Roeland M.H. Merks

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

This computational approach to the complexity of text comprehension is useful for describing the cognitive processes involved.

Existing work in probabilistic language modeling can be mostly divided into two categories:

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

Promotor: Prof.dr. F. den Hollander

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

The disappearance and reappearance of species of plants in the Netherlands is a normal phenomenon. In the period from 1981-2000 the number of plants to have disappeared was considerably lower than previously, whereas the number of species rediscovered is much higher. Climate change may be the cause.

Promotor: Prof.dr. E. Deprettere

The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.