What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?

Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.

PhD Defence

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Autism spectrum disorders are more often diagnosed in boys than in girls. For Developmental Psychology professor Carolien Rieffe this raises the question whether autism remains undiscovered in girls and women.

Lecture

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Semiha Aydin is one of the three first-generation researchers who received a grant from the Leiden Empowerment Fund to stimulate their scientific career.

PhD Defence

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

The research master's specialisation Developmental Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.

Supervisor: Indira Nederpelt

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Can excessive worrying be reduced via stimulation of the vagus nerve?

FSW Professor Jan Dirk Blom has written a book on Alice in Wonderland syndrome. This is the first scientific book on this rare disorder, which was first described in 1955 by the British psychiatrist John Todd. Todd was inspired by the famous book by Lewis Carroll, in which Alice experiences all kinds…

In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?

Undesirable associations with sex can be unlearned, but return if the circumstances change. They must therefore be unlearned in different situations. The drug D-cycloserine may help here. These are the findings of psychologist Mirte Brom.

PhD Defence

PhD Defence

Conference

Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”

Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.

Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?

PhD Defence

The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…

Overkleeft

Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands

PhD Defence

Members of our research team give different types of presentations and lectures.

Read about the impact of past research

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

An assessment approach that tailors to children’s instructional needs

Promotor: Prof.dr. J. den Hertog

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

From basic science to real-world interventions

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior

The group Clinical Neurodevelopmental Studies has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.

Research in the group Clinical Neurodevelopmental Studies is focused on understanding and influencing developmental mechanisms in children and adolescents.

Empathic or anxious mistakes? A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments