Abrupt Climate Change and Cultural Transformation

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

SOLID: Solidarity under strain - A legal, criminological and economic analysis of welfare states and free movement in the EU. Analysing the ways in which immigration structurally challenges and changes the organization and conceptual boundaries of national welfare states.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

The programme consists out of three phases: the orientations phase, de pre-PhD phase, and the PhD phase. Each phase has its own characteristics and goals, that are explained below.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

This project aims at determining the market value of hydrogen peroxide (HP) that is produced via our electrochemical methods that have been developed as part of the ERC-StG Cu4Energy project.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Implementation of the new sound synthesis and analysis method in music composition.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Advancing the understanding of the interaction of light and matter on the single-quantum level is important for near-future quantum technologies but also to answer fundamental questions.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: J. Zaanen

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Source: The AAPS journal, Volume 16, Issue 4, pp. 681-684 (2014)

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

A full overview of MCBIM PhD theses.

Science, Leiden Institute of Chemistry (LIC)

The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

The potential of bioneedles to deliver influenza vaccines was investigated.

Analysing the ways in which immigration structurally challenges and changes the organization and conceptual boundaries of national welfare states.