1,682 search results for “solid phase oligosaccharide synthesis” in the Public website
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Design, synthesis and application of paramagnetic probes for protein structure studies
PhD Defence
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'Q-wires': Synthesis, electrochemical properties and their application in electro-enzymology
PhD Defence
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Teachers’ professional learning preferences
How do secondary school teachers’ professional learning preferences relate to teaching experience and the school context?
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Career prospects
With a degree in Governance of Sustainability you are well prepared for broad array of career prospects in the field of sustainability, both inside and outside academia.
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Alverata, a present-day, European typeface with roots in the middle ages
The subject of this thesis is Alverata, a twenty-first-century typeface whose design was inspired by the shapes of Romanesque capitals such as those found in inscriptions of the eleventh and twelfth centuries.
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Archaeological investigations on St. Martin (Lesser Antilles).
The sites of Norman Estata, Anse des Pères and Hope Estate with a contribution to the 'La Hueca problem'
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Supramolecular polymer materials for biomedical applications and diagnostics
Self-assembly is an abundant process in nature and is vital to many processes in living organisms.
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D-lightful Sunshine Disrupted
This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Biomimetic models of [NiFe] hydrogenase for electrocatalytic hydrogen evolution
The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.
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Koriabo; From the Caribbean Sea to the Amazon River
This book is about the archaeology of indigenous peoples who thrived across the Caribbean, the Guianas, and the Lower Amazon basin just before the European invasion, and who also remained central to the early history of conquest and colonization.
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Kroese-Duijsters Symposium 2022
With its instalment in 2022, the Kroese-Duijsters Symposium will provide a platform for interaction between researchers from different fields and in different career stages, from doctoral students to world-leading professors.
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Domestic Homicide
Behavioral Sciences Mental Health Psychological Disorders - Adult Aggression in Adults Psychological Science Social Psychology Criminology & Delinquency Social Sciences Criminology and Criminal Justice Crime and Crime Prevention Criminal Behaviour and Forensic Psychology Violent Crime Law Criminology…
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Pots, Farmers and Foragers
Pottery traditions and social interaction in the earliest Neolithic of the Lower Rhine Area
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Prosody in whispered speech: retrieving alternative cues to pitch
The goal of this study is to systematically investigate how intonation (speech melody) is conveyed in whispered speech.
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Thomas Hansen
Thomas Hansen is our Leiden Institute of Chemistry's nominee for the C.J. Kok Jury Award 2020.
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Concurrent Systems
In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.
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Computer Systems, Imagery & media
The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Systems pharmacology of the endocannabinoid system
What are the functions of the endocannabinoid system?
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Beyond Prometheus
The research contained in this dissertation explores the origins of fire making in prehistory, focusing primarily on the fire use practices and fire production capacities of Neandertals.
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Tales of Orion: the interplay of gas, dust, and stars in the interstellar medium
Promotores: Prof.dr. A.G.G.M. Tielens & Prof.dr. L. Kaper (UvA)
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Between oral and written tradition- Reconstructing 'lost' singing practices of Quattrocento Italy
What kinds of vocal music were not typically transmitted in written musical notation? Can specific ‘lost’ song forms - siciliane, giustiniane, le Grechesche, gli stili “regionali“ nel canto del quattrocento - be more precisely identified than they have been until now, both in musicological research…
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Stereoelectronic and conformational effects in oxocarbenium, iminium and iminosugar ammonium ions
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
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Glycosyl Cations in Glycosylation Reactions
This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.
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Business Interests and the Development of the Modern Welfare State
This edited volume provides a synthesis on the question of business attitudes towards and its influence over the development of the modern welfare state. It gathers leading scholars in the field to offer both in-depth historical country case studies and comparative chapters that discuss contemporary…
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.
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Ultrasensitive in situ visualization of active glucocerebrosidase molecules
Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…
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Daan Hoogers
‘My studies have revolved around the, in my view, most intriguing subject in the natural sciences, chemistry. I followed the Molecular Science and Technology program's courses in my bachelor's, focussing on organic chemistry. These courses sparked my interest in this field, leading me to conduct my…
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Transitioning from Military Interventions to Long-Term Counter-Terrorism Policy
In December 2014, Leiden University’s Institute of Security and Global Affairs with the Australian National University’s Asia-Pacific College of Diplomacy and the International Centre for Counter-Terrorism, commenced a research project to assess how (temporary) military interventions can best prepare…
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Why Leiden University?
The Leiden Institute of Chemistry offers a unique tailor-made programme in Life Science and Technology. You can adapt the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either a Biomedical or Molecular approach of Life Sciences. During…
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Why Leiden University?
The Chemistry research in Leiden is conducted in two major research areas: Chemical Biology and Energy & Sustainability. You will be part of one of our multidisciplinary research teams.
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Dynamical Gibbs-non-Gibbs transitions and Brownian percolation
Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez
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Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling
The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…
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Selectivity
Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.
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FRESH Lecture: Visualizing single molecules and their reactivity at solid/liquid interfaces
Lecture
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Caribbean Connections: Cultural Encounters in a New World Setting (CARIB)
What socio-cultural transformations did indigenous communities in the Lesser Antilles undergo from the late precolonial to the early colonial period in response to Amerindian European-African cultural encounters? How did Amerindian populations realign themselves in response to the colonisation…
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Comprehending the symptomatic phase preceding Rheumatoid Arthritis: Clinically Suspect Arthralgia
PhD Defence
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Research Grant for tuning into photosynthesis
Biophysicist Anjali Pandit has been awarded a FOM 'Projectruimte' research grant for her proposal ‘Tuning into the photosynthetic membrane with atomistic precision’.
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
- Leiden Observatory
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Campus square
Over the coming years, the Leiden Bio Science Park will be transformed from a business park into a campus. The campus square will be the vibrant heart of this area. Here, the university, businesses and the city of Leiden get together.
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Investigating the possibilities and limitations of Process-oriented Dynamic Testing.
Can process-oriented dynamic testing be applied to everyday educational practice?