Which metabolites of sponge are influenced by individual environmental or biological factors?

Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:

Psycholinguistic research

Inspired and motivated by the chemical challenges associated with the societal energy transition, the Leiden Institute of Chemistry (LIC) aims to reach new fundamental insight into problems from materials science and interface chemistry. In furthering our understanding of the underlying processes, theoretical…

To address biological questions related to human health, chemical tools are essential. Covalent or non-covalent interactions of compounds with biomolecules offer a range of possibilities for study. They can be used to identify enzymes based on their activity, to influence cellular regulation, by changing…

In an Advance Online Publication biophysicist John van Noort and others show using magnetic tweezers that DNA is folded in compliant helices of chromatin. This allows enzymes access to the DNA needed for gene expression. Van Noort's research group made the discovery in close partnership with researchers…

The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit.

Good research means looking beyond disciplinary boundaries, said Professor of Molecular and Cellular Biochemistry Remus Dame in his inaugural lecture on 10 May. Processes that take place on DNA shouldn’t only be researched in a test tube but also in living cells, for instance.

These are the proposed research projects for LEAPS 2019. Please note that not all projects will go ahead and some may still be added in the near future. Final funding decisions lie with the Faculty sponsors. And please make a note that if you are interested in an ESA project, to check if your state…

Rottgering

Koper

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Science, Leiden Institute of Chemistry (LIC)

Bead microrheology: Analysis of active and passive transport in living cells

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

At Leiden Observatory, researchers investigate the origin of stars and their planetary systems. They detect and characterize planets around other stars (exoplanets). They study how stars and planets form. And they follow molecules from interstellar clouds to nascent planet systems. This way they address…

Science, Institute of Biology Leiden (IBL)

An unprecedented space telescope, an astrolab that makes space ice and molecules that may lead to the origin of life… The Ice Age project has all the prerequisites to become a very fascinating research project – if it is not one already. Leiden astronomers Melissa McClure, Harold Linnartz and Will Rocha…

Het project heeft plaats gevonden onder begeleiding van Prof.dr.ir.Tjerk Oosterkamp. De titel van de presentatie is:

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit and chemist Hermen Overkleeft.

Protein chains typically fold to function. Folding is a complex process and if done correctly leads to a unique functional fold topology for a given protein chain. Other topologies are also possible but are often non-functional or toxic. These misfolded proteins are then unfolded and subsequently refolded…

Thomas Hansen is the recipient of the 2020 KNCV-Backer Prize for best organic chemistry thesis in the Netherlands.

The Royal Netherlands Academy of Arts and Sciences has elected five Leiden professors from different disciplines as new members. Two of the new members are women.

Milan Allan has received the Bryan R. Coles Prize at the International Conference on Strongly Correlated Electron Systems (SCES) in Prague.

Nicolaas Bloembergen, who won the Nobel Prize in Physics in 1981, passed away on 5 September in Tucson, Arizona. Bloembergen obtained his PhD on nuclear spin resonance in 1948 at Leiden University. Some articles about his life.

Of this year’s four NWO Spinoza Prizes, two have been awarded to Leiden researchers. On 12 September, Eveline Crone and Michel Orrit received their prizes, the highest scientific award in the Netherlands. The Spinoza Prize carries an award of 2.5 million euros.

The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.

While there are numerous and extremely advanced methods to sequence the genome, only a few methods exist to sequence the proteome. The Vidi project of Grégory Schneider promises to shed light on the most difficult paradigm of proteomics: achieving an error-free determination of the sequence of single…

We learned of the passing away of Nicolaas Bloembergen, Nobel Prize winner in Physics (1981) at the age of 97.

The National Roadmap for Large-Scale Research Facilities programme of NWO enables the building or renovation of research facilities with international allure. Leiden NMR groups take part in the uNMR-NL consortium coordinated by Marc Baldus (Utrecht University) that has been awarded almost 18 million…

Former PhD student Cameron Mackie will been awarded not one, but two dissertation prizes for his thesis on the aromatic universe. His work could provide us with a virtual sniff of space. ‘These molecules in space likely smell like a big charcoal grill!’

After 25 years, this December will finally see the launch of the long-awaited James Webb space telescope (JWST). Leiden astronomers are watching with great excitement: not only were they involved in the construction of important instruments on board, but the telescope will also reveal many new secrets…

Science, Leiden Institute of Physics (LION)

Science, Leiden Institute of Physics (LION)

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Science, Leiden Institute of Chemistry (LIC)

Science, Institute of Biology Leiden (IBL)

Science, Leiden Institute of Physics (LION)

Speakers that have accepted to participate:

Science, Leiden Academic Centre for Drug Research (LACDR)

Plants could be regarded as small chemical factories, which produce chemical substances via photosynthesis. If we can imitate photosynthesis in an artificial system, we can make clean fuels and materials out of sunlight and CO2. Huub de Groot is very close to designing a system of this kind.

Science, Institute of Biology Leiden (IBL)

Because we cannot directly ask babies about what they know or what they are thinking about, we must find smart and baby-friendly ways to figure it out! Below you can read about the different methods that we typically use in our studies.

Science, Leiden Academic Centre for Drug Research (LACDR)

Science, Leiden Academic Centre for Drug Research (LACDR)

Biophysicist Rolf Harkes has developed a microscope to optically localize individual molecules in living cells. It improves monitoring of diseases like cancer and Parkinson’s at the cellular level. Defende PhD thesis on t13 January 2016.