343 search results for “single-molecule spectroscopy” in the Public website
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Spectroscopy of two-field inflation
PhD defence
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Infrared Spectroscopy of Astrophysically Relevant Hydrocarbons
PhD defence
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Cold gas in distant galaxies
The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.
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Visualising the nanoworld
Visualising cell proteins without invasive techniques is possible with the help of fluorescence. During a lecture of the Natuurwetenschappelijk Gezelschap Leiden on 18 January, winner of the Spinoza Prize 2017 and founder of the field of single molecule optics Michel Orrit explained how this works.
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Michel Orrit wins Physica Prize 2016
Michel Orrit was awarded the Physica prize 2016 for his groundbreaking work on single molecule spectroscopy.
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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From Star-formation to Recombination: Expanding our View of the Radio-Recombination-Line Universe
The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).
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Facilities
Our facilities cover:
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Single-molecule kinetics studied by nanoplasmonic fluorescence enhancement and by biomolecular electron transfer
PhD defence
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Plasmonic Enhancement of Single-Molecule Fluorescence under One- and Two-Photon Excitation
PhD defence
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
PhD defence
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ImageInLife: Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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Exploring Strange New Worlds with High-Dispersion Spectroscopy
PhD defence
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
PhD defence
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Advanced Imaging and Spectroscopy Techniques for Body Magnetic Resonance
PhD defence
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Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations
PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.
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The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.
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Early stellar galaxies
Franx
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Infrastructure
An overview of our infrastructure at the SPP division:
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applications of paramagnetic NMR spectroscopy for protein research
PhD defence
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High-resolution integral-field spectroscopy of exoplanets
PhD defence
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Supramolecular and Biomaterials Chemistry
Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…
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SDS-PAGE at the nanoscale: A nanorecorder for single molecule protein sequencing with graphene
Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?
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Redox catalysis for a sustainable energy infrastructure
The main research theme in the group of Dennis Hetterscheid is to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. Reduction of protons generates hydrogen that can be used as a chemical fuel. Alternatively to gaseous hydrogen, the reduction…
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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Feedback from deeply embedded low- and high-mass protostars. Surveying hot molecular gas with Herschel
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg
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Microcoil MRI of Plants and Algae at Ultra-High Field: An exploration of metabolic imaging
This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).
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Doris Jacobs
Dr. Doris M. Jacobs, Lead Scientist at Unilever R&D, Wageningen, The Netherlands.
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Mesoamerican manuscripts: new scientific approaches and interpretations
Mesoamerican Manuscripts: New Scientific Approaches and Interpretations brings together a wide range of modern approaches to the study of pre-colonial and early colonial Mesoamerican manuscripts. This includes innovative studies of materiality through the application of non-invasive spectroscopy and…
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Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen
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Expertise
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…
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Gold nanorod photoluminescence: applications to imaging and temperature sensing
Promotor: M.A.G.J. Orrit
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Research profiles
The Leiden Institute of Chemistry has opened 5 - 6 staff positions for research related to its two focus areas, Energy & Sustainability and Chemical Biology. We offer an attractive research and teaching environment, including scientific independence, a collaborative atmosphere, attractive start-up packages…
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ParaNMR Facility
The Paramagnetic NMR Facility Leiden has been established to provide support to researchers who want to apply paramagnetic NMR spectroscopy to biomolecules. Support is offered in the design and synthesis of paramagnetic probes, either for general application (such as lanthanide tags and spin labels)…
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In shape for photoregulation
How does the photoregulation mechanism work in detail?
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Research lines
Current research at the Skin Barrier and Vaccination group.
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Reedijk Symposium 2022: In situ X-ray spectroscopy for a live view on electrochemistry
Lecture
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FRESH Lecture: Photoelectron spectroscopy in the gas-phase and in liquid-jets
Lecture
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of Pigments on Archaeological Artifacts on site by Mobile Imaging Spectroscopy
Lecture
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FRESH Lecture: Spectroscopy and Structures of LPMOs: Copper Oxygenases that Oxidize Cellulose
Lecture
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Metabolic and Functional Evaluation of Diabetic Cardiomyopathy using MR Spectroscopy and MR Imaging
PhD defence
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X-ray spectroscopy of interstellar dust: From the laboratory to the Galaxy
PhD defence
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Joan van der Waals colloquium
Lecture
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Senior research analyst
Science, Leiden Institute of Physics (LION)
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Senior research analyst
Science
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Searching for the sibling of the earth
Are there other planets like the earth, and will there also be life? Astronomers study planets around stars other than the sun, with the aim to find out what kind of gasses their atmospheres are made up with.
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Reconstruction Methods for Combined HAADF-STEM and EDS Tomography
The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.