332 search results for “single-molecule spectroscopy” in the Public website
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Hocelayne Paulino Fernandes
Science
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Michel Orrit
Science
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Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule
Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma
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Alireza Mashaghi Tabari
Science
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Real-time solid-state NMR spectroscopy inside living cells
Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
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Hot Nanoparticles
Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.
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Catalysis of the electrochemical water oxidation to oxygen
Promotor: M.T.M. Koper, Co-Promotor: F. Calle-Vallejo
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame
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Colloidal LEGO with peptides
Kros
- Jan van Ruitenbeek Lab (Atomic and Molecular Conductors)
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Dark ice chemistry in interstellar clouds
This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Bernhard Brandl
Science
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Laboratory studies of Water Ice in Space
Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.
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Magnetism and magnetization dynamics in thin film ferromagnets
Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek
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Kimberly Emig
Science
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Leindert Boogaard
Science
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Young Hae Choi
Science
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Michel Orrit Wins Edison Volta Prize
The European Physical Society has awarded the prestigieus Edison Volta Prize to Leiden physicist Michel Orrit. The prize is handed out every two years to an individual or a group of at most three scientists as an acknowledgment of an outstanding achievement in physics research.
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Inferno Worlds
A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.
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From the root of variation: A metabolomics perspective to plant soil-feedback
By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.
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Galaxy formation traced by heavy element pollution
Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.
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Applications of Natural Deep Eutectic Solvents to Extraction and Preservation of Biomolecules
The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
- Ultramicroscopy
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Joan van der Waals colloquium
The Joan Van der Waals colloquium is an ongoing bi-weekly lecture series.
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Portable Laser-Induced Breakdown Spectroscopy (LIBS) as a sample-reducing strategy in Archaeology
Lecture
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Lipid to protein ratio plays an important role in the skin barrier function of atopic eczema patients
The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).
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The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes
The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Thomas Schmidt Lab (Single Molecule Microscopy)
Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Quantum Matter and Optics
The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.
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Sarantos Kostidis
Dr. in Biomedical NMR spectroscopy, LUMC, Leiden - The Netherlands
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PhD Theses
A full overview of MacBio PhD Theses.
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle).
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Operando research in electrochemistry
The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…
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X-ray spectroscopy of merging galaxy clusters
PhD Defence
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Medical Systems Biophysics and Bioengineering
The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.
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Stefan Semrau Lab (Quantitative Single-Cell Biology)
We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.
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Movements of steroid receptors inside the cell nucleus unraveled
Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.
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Electronic spectroscopy of molecules of astrophysical interest
PhD Defence
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Infrared Spectroscopy of Astrophysically Relevant Hydrocarbons
PhD Defence
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Spectroscopy of two-field inflation
PhD Defence
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Cold gas in distant galaxies
The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.
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Visualising the nanoworld
Visualising cell proteins without invasive techniques is possible with the help of fluorescence. During a lecture of the Natuurwetenschappelijk Gezelschap Leiden on 18 January, winner of the Spinoza Prize 2017 and founder of the field of single molecule optics Michel Orrit explained how this works.
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Michel Orrit wins Physica Prize 2016
Michel Orrit was awarded the Physica prize 2016 for his groundbreaking work on single molecule spectroscopy.
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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From Star-formation to Recombination: Expanding our View of the Radio-Recombination-Line Universe
The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).