2,038 search results for “single molecule” in the Public website
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Plasmonic Enhancement of Single-Molecule Fluorescence under One- and Two-Photon Excitation
PhD defence
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Joan van der Waals colloquium
The Joan Van der Waals colloquium is an ongoing bi-weekly lecture series.
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Physicists image individual molecules by watching them absorb light
Molecules are extremely hard to see in visible light, especially without using fluorescence. Leiden physicists have now made their optical technique sensitive enough to image the molecules of their interest in all sizes. Publication in Nanoletters.
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Medical Systems Biophysics and Bioengineering
The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.
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Our approach
Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:
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Strategy
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Quantum dots in microcavities: From single spins to engineered quantum states of light
PhD defence
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Two-photon luminescence of gold nanorods: applications to single-particle tracking and spectroscopy
Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.
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Biophysicists unravel exact folding of a single gene
The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.
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Linking simple molecules to grain evolution across planet-forming disks
Planets are formed in disks of gas and dust around young stars.
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Monitoring the penetration process of single microneedles with varying tip diameters
Microneedles represent promising tools for delivery of drugs to the skin. However, before these microneedles can be used in clinical practice, it is essential to understand the process of skin penetration by these microneedles.
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From molecules to monitoring: Integrating genetic tools into freshwater quality assessments
Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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Structure dependence of molecular reactions on surfaces
The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.
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Structural Properties of Single Server Queueing Systems: Efficient Methods via Lumping and Dynamic Programming
This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Institute of Biology Leiden
The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.
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Frontiers of Modern Physics
The Leiden Institute of Physics (LION) Summer School offers outstanding students the opportunity to discover the research frontiers of modern physics. The 10-day program includes a series of seminars by renowned physicists on variety of special topics, visits to research laboratories, and a range of…
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Teaching synthetic molecules how to communicate
Although Sander Wezenberg just started working in Leiden in March this year, he already managed to win a Vidi grant from NWO. Inspired by nature, Wezenberg wants to bring synthetic molecules to life and teach them to communicate. But who exactly is Wezenberg and what drives him?
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Complex Organic Molecules Discovered in Infant Star System
For the first time, astronomers have detected the presence of complex organic molecules, the building blocks of life, in a protoplanetary disc surrounding a young star. The discovery reaffirms that the conditions that spawned the Earth and Sun are not unique in the Universe. The results are published…
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Understanding Single Photon Detectors
Leiden physicists have developed a way to address how accurately a superconducting single photon detector (SSPD) can be characterized by detector tomography. SSPDs are not fully understood, and tomography is a key element to determine how these devices detect light. A better understanding of these detectors…
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In Pursuit of Next-Generation Lipopeptide Antibiotics
Can new variants of daptomycin and the polymyxins be found?
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Improving the filamentous fungus Aspergillus niger as cell factory for starch degrading enzymes
We aim to develop A. niger strains that produce more starch degrading enzymes even in the absence of starch.
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Speed gun for molecules
Detecting molecules with temperature instead of chemical reactions: that’s what scientists from the Leiden Institute of Physics want to do. They are developing a sensor that utilizes special nanoparticles to keep track of certain molecules. In this way, they can for example see how well new drugs do…
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1720‐1840, Rediscovering the lost pedal techniques on harps with a single‐action pedal mechanism
The “harpe organisée”, 1720-1840: Rediscovering the lost pedal techniques on harps with a single-action pedal mechanism, is the title of Maria Christina Cleary's PhD thesis. This is the first monographic study on harp pedal techniques, tracing the historical way to pedal on the early pedal harps with…
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Adsorption and catalysis on Pt and Pd monolayer-modified Pt single crystal electrodes
The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.
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Leiden physicists detect single nanoparticles in motion
It's pretty hard to spot a single 5 nanometer particle. Leiden physicists pulled it off by turning a 120 nm gold rod into a detector.
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Advanced Pre-clinical Evaluation of the Guanidino Lipoglycopeptides: A Novel Family of Glycopeptide Antibiotics with Best-in-Class Potential
Can we make a better vancomycin?
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Detecting diseases with molecules in the body
Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…
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Dynamics of Single Protein Molecules by Temperature Cycling under Laser Heating
PhD defence
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Non-linear astrochemical kinetics: theory and applications
This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.
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Supramolecular and Biomaterials Chemistry
Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…
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Synthetic biology and genomics platform for new-to-nature bioactive peptides
Can the venom of snakes, scorpions and other animals be sources of new antibiotics?
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NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
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The role of zebrafish (Danio rerio) larvae in developing new drug candidates for treating anxiety, from natural sources
Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?
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Determining the structure of a chemotaxis kinase complex with receptor mimetics and cryo-EM
Can we determine the 3D structure of a chemotaxis core complex using single-particle reconstructions via cryo-EM?
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Building molecules with sustainable energy
The E2CB programme has been launched to bring CO2 emissions to zero by 2050. The goal: to produce all raw materials for the chemical industry from sustainable sources. Professor of Electrochemistry Marc Koper is involved in the project.
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Spinoza Prize for Michel Orrit, Professor of Spectroscopy
It is partly thanks to Leiden professor Michel Orrit that we are today able to study individual molecules. He just missed winning a Nobel Prize, but is today the recipient of another important scientific award: NWO’s prestigious Spinoza Prize.
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Small molecule prevents tumour cells from spreading
Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…
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Novel approaches to develop filamentous micro-organisms for enzyme production (FILAZYME)
Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?
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Efficient targeting of the Trichoderma genome for industrial protein engineering
The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.
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UM Cure 2020: New therapies for uveal melanoma
Can we bring novel treatment options to the clinic for UM patients with liver metastases?
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Research
Research at the SBC group is comprised of the following research themes:
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Advanced Spectroscopy
To achieve a more sustainable society, it is important to move away from cradle-to-grave applications, and to develop a more circular economy, wherein reusability and recycling are part of the development of any new product. In that context, the currently undergoing change of chemical feedstocks from…
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Going accurate for molecule – metal surface interactions
Researchers from the THEOR CHEM group at Leiden University strive to set new benchmarks in the accuracy of the prediction of interaction energies between molecules and metal surfaces.
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Anticancer compounds from actinomycetes
How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?
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Football molecule explains 100-year-old astronomical problem
Exactly a century ago, astronomers observed the first two diffuse interstellar bands (DIBs) in space. A DIB manifests itself as a colour of light that is missing in the radiation from stars behind an interstellar cloud. Although about 500 DIBs are yet discovered, they remained inexplicable until recently.…
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Galactofuranose biosynthesis in the filamentous fungus Aspergillus niger
This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.